β-carotene-loaded nanoparticles protect against neuromotor damage, oxidative stress, and dopamine deficits in a model of Parkinson's disease in Drosophila melanogaster

Chaves, Nathalie Savedra Gomes; Janner, Dieniffer Espinosa; Poetini, Márcia Rósula; Fernandes, Eliana Jardim; Almeida, Francielli Polet de; Musachio, Elize Aparecida Santos; Reginaldo, Jocemara Corrêa; Dahleh, Mustafa Munir Mustafa; Carvalho, Amarilis Santos de; Leimann, Fernanda Vitória; Gonçalves, Odinei Hess; Ramborger, Bruna Piaia; Roehrs, Rafael; Prigol, Marina; Guerra, Gustavo Petri

doi:10.1016/j.cbpc.2023.109615

Cited by 5 publications

(2 citation statements)

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“…Several recent studies showed the neuroprotective role of carotenoids on neuronal in vitro and in vivo models. B-carotene, one of the most famous carotenoids, was investigated as a possible adjuvant in the therapy of PD by Chaves et al [ 43 ]. B-carotene-loaded nanoparticles presented a significant neuroprotective effect against rotenone-induced damage in Drosophila melanogaster.…”

Section: Vitaminsmentioning

confidence: 99%

“…Rotenone is a mitochondrial Complex I inhibitor, which has been demonstrated to be responsible for PD-like behavioural and neuropathological changes, such as the initiation of apoptosis and quickening of α-synuclein formation in PD models [ 44 ]. The researchers showed that β-carotene-loaded nanoparticles can protect against the locomotor damage and memory deficit induced by rotenone, ameliorating dopamine levels and oxidative stress [ 43 ]. Additionally, in 2013 a study was conducted by Chang et al [ 45 ], which tested the neuroprotective effects of astaxanthin, beta-carotene, and canthaxanthin on undifferentiated rat pheochromocytoma (PC12) cells, a useful neuronal model for studying some neurodegenerative diseases.…”

Section: Vitaminsmentioning

confidence: 99%

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Food and Food Waste Antioxidants: Could They Be a Potent Defence against Parkinson’s Disease?

Cannas,

Lostia,

Serra

et al. 2024

Antioxidants

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Oxidative stress, an imbalance between reactive oxygen species (ROS) and endogenous antioxidants, plays an important role in the development of neurodegenerative diseases, including Parkinson’s. The human brain is vulnerable to oxidative stress because of the high rate of oxygen that it needs and the high levels of polyunsaturated fatty acids, which are substrates of lipid peroxidation. Natural antioxidants inhibit oxidation and reduce oxidative stress, preventing cancer, inflammation, and neurodegenerative disorders. Furthermore, in the literature, it is reported that antioxidants, due to their possible neuroprotective activity, may offer an interesting option for better symptom management, even Parkinson’s disease (PD). Natural antioxidants are usually found in several foods, such as fruits, vegetables, meat, fish, and oil, and in food wastes, such as seeds, peels, leaves, and skin. They can help the system of endogenous antioxidants, protect or repair cellular components from oxidative stress, and even halt lipid, protein, and DNA damage to neurons. This review will examine the extent of knowledge from the last ten years, about the neuroprotective potential effect of natural antioxidants present in food and food by-products, in in vivo and in vitro PD models. Additionally, this study will demonstrate that the pool of dietary antioxidants may be an important tool in the prevention of PD and an opportunity for cost savings in the public health area.

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Section: Vitaminsmentioning

confidence: 99%