β-carotene targets IP3R/GRP75/VDAC1-MCU axis to renovate LPS-induced mitochondrial oxidative damage by regulating STIM1

Meng, Meijuan; Jiang, Yijin; Wang, Yan; Huo, Ran; Ma, Nana; Shen, Xiang; Chang, Guangjun

doi:10.1016/j.freeradbiomed.2023.05.021

Cited by 14 publications

(3 citation statements)

References 62 publications

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“…As shown in Figure A, there were no obvious influences of cell viability by TPP, TPS, and TB since the concentrations lower than 100 μg/mL and 50 μg/mL were selected for follow-up study. It has been reported that excessive ROS was produced by mitochondria in the LPS-induced cell inflammatory model, which promoted mitochondrial membrane damage and cause apoptosis . In agreement with this view, as shown in Figure B, excessive ROS accumulation caused by LPS in RAW264.7 cells was detected using a flow cytometer and quantified by fluorescence intensity.…”

Section: Resultssupporting

confidence: 82%

“…It has been reported that excessive ROS was produced by mitochondria in the LPS-induced cell inflammatory model, which promoted mitochondrial membrane damage and cause apoptosis. 32 In agreement with this view, as shown in Figure 7B, excessive ROS accumulation caused by LPS in RAW264.7 cells was detected using a flow cytometer and quantified by fluorescence intensity. Apparently, Figure 7D demonstrates that TPP, TPS, and TB could effectively reverse the enhancement of ROS level by LPS.…”

Section: Pearson Correlation Analysis Between Gut Microbiota and Coli...supporting

confidence: 78%

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Amelioration Effects and Regulatory Mechanisms of Different Tea Active Ingredients on DSS-Induced Colitis

Wei,

Wang

et al. 2023

J. Agric. Food Chem.

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The potential biological function of tea and its active components on colitis has attracted wide attention. In this study, different tea active ingredients including tea polyphenols (TPPs), tea polysaccharides (TPSs), theabrownin (TB), and theanine (TA) have been compared in the intervention of dextran sulfate sodium (DSS)-induced colitis in mice. Specifically, TPP showed the greatest effect on colitis since it reduced 60.87% of disease activity index (DAI) compared to that of the DSS-induced colitis group, followed by the reduction of 39.13% of TPS and 28.26% of TB on DAI, whereas there was no obvious alleviative effect of TA on colitis. TPP, TPS, and TB could regulate the composition and abundance of gut microbiota to increase the content of short-chain fatty acids (SCFAs) and enhance intestinal barrier function. Further evidence was observed that TPP and TPS regulated the activation of Nrf2/ARE and the TLR4/MyD88/NF-κB P65 pathway to alleviate the colitis. Results of cell experiments demonstrated that TPP showed the greatest antiapoptosis and mitochondrial function protective capability among the tea ingredients via inhibiting the Cytc/Cleaved-caspase-3 signaling pathway. In summary, the superior anticolitis activity of TPP compared to TPS and TB is primarily attributed to its unique upregulation of the abundance of Akkermansia and its ability to regulate the mitochondrial function.

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Section: Resultssupporting

confidence: 82%

Section: Pearson Correlation Analysis Between Gut Microbiota and Coli...supporting

confidence: 78%

Amelioration Effects and Regulatory Mechanisms of Different Tea Active Ingredients on DSS-Induced Colitis

Wei,

Wang

et al. 2023

J. Agric. Food Chem.

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“…The binding of LPS to the Toll-like receptor 4 (TLR4) receptor on macrophage surfaces can activate the NF-κB pathway, leading to upregulation of gene expressions such as IL-6, TNF-ɑ, and iNOS, thereby inducing an inflammatory reaction in the body [ 26 ]. Simultaneously, LPS can also induce ROS outbreak and oxidative stress in cells by activating the NOX2/ROS pathway [ 27 ], interfering with mitochondria [ 28 ], and downregulating antioxidant enzymes [ 29 ]. An appropriate inflammatory reaction and oxidative stress are beneficial for pathogen elimination, while excessive or chronic inflammation and oxidative stress may contribute to diseases like fibrosis [ 30 ], diabetes [ 31 ], cancer [ 32 ], and Alzheimer’s disease [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

The Extracts Derived from Artemisia japonica Thunb. Leaves Mitigate Oxidative Stress and Inflammatory Response Induced by LPS in RAW264.7 Cells through Modulation of the Nrf2/HO-1 Signaling Pathway

Ye,

Li,

Chen

et al. 2024

Molecules

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Artemisia japonica Thunb. has been used as a traditional Chinese medicine and a vegetable for thousands of years in China. However, there are few reports on the chemical composition and biological activity of its leaves. Thus, this study aimed to evaluate the chemical composition, antioxidant and anti-inflammatory effects of water extracts of A. japonica leaves and their underlying mechanisms. A total of 48 compounds were identified in the water extract using UPLC-QTOF-MS2 analysis, with phenolic acids, particularly chlorogenic acid compounds, being the predominant components. The ethyl acetate fraction (EAF) contained most of the total phenolic content (385.4217 mg GAE/g) and displayed superior antioxidant capacity with the IC50DPPH•, IC50ABTS•+, and OD0.5reducing power at 10.987 μg/mL, 43.630 μg/mL and 26.883 μg/mL, respectively. Furthermore, EAF demonstrated potent antioxidant and anti-inflammatory effects in LPS-induced RAW264.7 cells by upregulating the Nrf2/HO-1 signal pathway. These findings highlight that A. japonica leaves possess remarkable abilities to mitigate inflammation and oxidative stress, suggesting their potential utilization as medicinal agents and food additives for promoting human health.

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STIM2 variants regulate Orai1/TRPC1/TRPC4-mediated store-operated Ca2+ entry and mitochondrial Ca2+ homeostasis in cardiomyocytes

Luo,

Gourriérec,

Antigny

et al. 2024

Cell Calcium

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β-carotene targets IP3R/GRP75/VDAC1-MCU axis to renovate LPS-induced mitochondrial oxidative damage by regulating STIM1

Cited by 14 publications

References 62 publications

Amelioration Effects and Regulatory Mechanisms of Different Tea Active Ingredients on DSS-Induced Colitis

Amelioration Effects and Regulatory Mechanisms of Different Tea Active Ingredients on DSS-Induced Colitis

The Extracts Derived from Artemisia japonica Thunb. Leaves Mitigate Oxidative Stress and Inflammatory Response Induced by LPS in RAW264.7 Cells through Modulation of the Nrf2/HO-1 Signaling Pathway

STIM2 variants regulate Orai1/TRPC1/TRPC4-mediated store-operated Ca2+ entry and mitochondrial Ca2+ homeostasis in cardiomyocytes

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