β‐catenin‐driven binary cell fate decisions in animal development

Bertrand, Vincent

doi:10.1002/wdev.228

Cited by 16 publications

(16 citation statements)

References 74 publications

(206 reference statements)

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“…S4E) (Hudson et al, 2016). The mechanism of nβ-catenin-mediated transcriptional repression described in the present and previous (Oda- Ishii et al, 2016) studies is different from other mechanisms described in Caenorhabditis elegans and Drosophila melanogaster (Bertrand, 2016;Blauwkamp et al, 2008;Murgan et al, 2015). Thus, nuclear β-catenin-dependent transcriptional repression appears to be mediated by diverse mechanisms.…”

Section: Discussioncontrasting

confidence: 53%

Antagonism between β-catenin and Gata.a sequentially segregates the germ layers of ascidian embryos

et al. 2016

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Many animal embryos use nuclear β-catenin (nβ-catenin) during the segregation of endomesoderm (or endoderm) from ectoderm. This mechanism is thus likely to be evolutionarily ancient. In the ascidian embryo, nβ-catenin reiteratively drives binary fate decisions between ectoderm and endomesoderm at the 16-cell stage, and then between endoderm and margin (mesoderm and caudal neural) at the 32-cell stage. At the 16-cell stage, nβ-catenin activates endomesoderm genes in the vegetal hemisphere. At the same time, nβ-catenin suppresses the DNA-binding activity of a maternal transcription factor, Gata.a, through a physical interaction, and Gata.a thereby activates its target genes only in the ectodermal lineage. In the present study, we found that this antagonism between nβ-catenin and Gata.a also operates during the binary fate switch at the 32-cell stage. Namely, in marginal cells where nβ-catenin is absent, Gata.a directly activates its target, Zic-r.b (ZicL), to specify the marginal cell lineages. Thus, the antagonistic action between nβ-catenin and Gata.a is involved in two consecutive stages of germ layer segregation in ascidian embryos.

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Section: Discussioncontrasting

confidence: 53%

Antagonism between β-catenin and Gata.a sequentially segregates the germ layers of ascidian embryos

et al. 2016

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“…Several pathways have been implicated in the control of these terminal asymmetric divisions. In vertebrates and C. elegans, the Wnt pathway plays a role in the regulation of neuronal progenitor asymmetric divisions (reviewed in Bertrand, 2016;Bielen and Houart, 2014). For example, in the mouse cortex, it has been observed that the Wnt pathway regulates the generation of neurons from neural stem cells (Woodhead et al, 2006;Zhang et al, 2010) and the asymmetry of neural stem cell divisions (Delaunay et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…We have previously shown that the terminal asymmetric divisions of embryonic neuronal progenitors are regulated by a particular Wnt pathway termed the Wnt/β-catenin asymmetry pathway (Bertrand and Hobert, 2009). This pathway regulates several asymmetric divisions during C. elegans embryonic and postembryonic development (Bertrand, 2016;Kaletta et al, 1997;Phillips and Kimble, 2009;Sawa and Korswagen, 2013). Whether Wnt ligands regulate the terminal asymmetric divisions of neuronal progenitors in the embryo remains to be determined.…”

Section: Introductionmentioning

confidence: 99%

Wnt ligands regulate the asymmetric divisions of neuronal progenitors in C. elegans embryos

et al. 2020

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Wnt/β-catenin signaling has been implicated in the terminal asymmetric divisions of neuronal progenitors in vertebrates and invertebrates. However, the role of Wnt ligands in this process remains poorly characterized. Here we used the terminal divisions of the embryonic neuronal progenitors in C. elegans to characterize the role of Wnt ligands during this process focusing on a lineage that produces the cholinergic interneuron AIY. We observed that during interphase the neuronal progenitor is elongated along the anteroposterior axis, then divides along its major axis, generating an anterior and a posterior daughter with different fates. Using timecontrolled perturbations, we show that three Wnt ligands, which are transcribed at higher levels at the posterior of the embryo, regulate the orientation of the neuronal progenitor and its asymmetric division. We also identified a role for a Wnt receptor (MOM-5) and a cortical transducer APC (APR-1), which are respectively enriched at the posterior and anterior poles of the neuronal progenitor. Our study establishes a role for Wnt ligands in the regulation of the shape and terminal asymmetric divisions of neuronal progenitors, and identifies downstream components.

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“…The results presented here led us to tentatively conclude that DWnt2 affects cell fate determination of testis-relevant myoblasts. Indeed, it has been shown that Wnt signaling specifies cell identity of a subset of somatic muscle founder cells in Drosophila embryogenesis ( Baylies et al, 1995 ) and during many other determinations of the fate of the cell ( Bertrand, 2016 ; Munoz-Descalzo et al, 2015 ). However, an additional later role in the migration of testis myotubes cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

Myotube migration to cover and shape the testis ofDrosophiladepends on Heartless, Cadherin/Catenin, and myosin II

et al. 2017

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During Drosophila metamorphosis, nascent testis myotubes migrate from the prospective seminal vesicle of the genital disc onto pupal testes and then further to cover the testes with multinucleated smooth-like muscles. Here we show that DWnt2 is likely required for determination of testis-relevant myoblasts on the genital disc. Knock down of fibroblast growth factor receptor (FGFR) heartless by RNAi and a dominant-negative version revealed multiple functions of Heartless, namely regulation of the amount of myoblasts on the genital disc, connection of seminal vesicles and testes, and migration of muscles along the testes. Live imaging indicated that the downstream effector Stumps is required for migration of testis myotubes on the testis towards the apical tip. After myoblast fusion, myosin II is needed for migration of nascent testis myotubes, in which Thisbe-dependent fibroblast growth factor (FGF) signaling is activated. Cadherin-N is essential for connecting these single myofibers and for creating a firm testis muscle sheath that shapes and stabilizes the testis tubule. Based on these results, we propose a model for the migration of testis myotubes in which nascent testis myotubes migrate as a collective onto and along the testis, dependent on FGF-regulated expression of myosin II.

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β‐catenin‐driven binary cell fate decisions in animal development

Cited by 16 publications

References 74 publications

Antagonism between β-catenin and Gata.a sequentially segregates the germ layers of ascidian embryos

Antagonism between β-catenin and Gata.a sequentially segregates the germ layers of ascidian embryos

Wnt ligands regulate the asymmetric divisions of neuronal progenitors in C. elegans embryos

Myotube migration to cover and shape the testis ofDrosophiladepends on Heartless, Cadherin/Catenin, and myosin II

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