2023
DOI: 10.1002/bab.2424
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β‐Catenin‐treated peptides effectively inhibit the proliferation of colorectal cancer

Abstract: To verify the inhibitory mechanism of β‐catenin‐designed peptides in colorectal cancer(CRC) tumors, the following experiments were performed. In vitro colony formation, Transwell assays, and flow cytometry were performed to assess the biological effects of designed peptides (F18KD, F20A4‐7k, F20A4‐10k, and F20A3‐9k + F20A4‐10k + F20A5‐9k) in HT‐29 cells. In vivo xenograft experiments were performed and treated with peptides. Next, tumors were subjected to Hematoxylin and eosin staining (HE), immunohistochemica… Show more

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