β-Cryptoxanthin Improves p62 Accumulation and Muscle Atrophy in the Soleus Muscle of Senescence-Accelerated Mouse-Prone 1 Mice

Noguchi, M.; Kitakaze, Tomoya; Kobayashi, Yasuyuki; Mukai, Katsuyuki; Harada, Naoki; Yamaji, Ryoichi

doi:10.3390/nu12082180

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…The ratio of p62-positive fibers to p62-negative fibers in a CSA of the soleus muscle was also decreased in β-cryptoxanthin-administered SAMP1 mice compared with that in non-treated mice. Accordingly, muscle mass, CSA, and MHC type I protein levels in the soleus were increased in β-cryptoxanthin-treated SAMP1 mice compared with those in non-treated SAMP1 mice [98].…”

Section: Improvement In Maintenance Of Protein Homeostasis By Natural...mentioning

confidence: 87%

A Comprehensive Review of Pathological Mechanisms and Natural Dietary Ingredients for the Management and Prevention of Sarcopenia

2023

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Sarcopenia is characterized by an age-related loss of skeletal muscle mass and function and has been recognized as a clinical disease by the World Health Organization since 2016. Substantial evidence has suggested that dietary modification can be a feasible tool to combat sarcopenia. Among various natural dietary ingredients, the present study focused on botanical and marine extracts, phytochemicals, and probiotics. Aims of this review were (1) to provide basic concepts including the definition, diagnosis, prevalence, and adverse effects of sarcopenia, (2) to describe possible pathological mechanisms including protein homeostasis imbalance, inflammation, mitochondrial dysfunction, and satellite cells dysfunction, and (3) to analyze recent experimental studies reporting potential biological functions against sarcopenia. A recent literature review for dietary ingredients demonstrated that protein homeostasis is maintained via an increase in the PI3K/Akt pathway and/or a decrease in the ubiquitin–proteasome system. Regulation of inflammation has primarily targeted inhibition of NF-κB signaling. Elevated Pgc-1α or Pax7 expression reverses mitochondrial or satellite cell dysfunction. This review provides the current knowledge on dietary components with the potential to assist sarcopenia prevention and/or treatment. Further in-depth studies are required to elucidate the role of and develop various dietary materials for healthier aging, particularly concerning muscle health.

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Section: Improvement In Maintenance Of Protein Homeostasis By Natural...mentioning

confidence: 87%

A Comprehensive Review of Pathological Mechanisms and Natural Dietary Ingredients for the Management and Prevention of Sarcopenia

2023

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Section: Discussionmentioning

confidence: 97%

“…β-Cryptoxanthin, a provitamin A carotenoid, suppresses atrophy of the soleus muscle, but not of the gastrocnemius, EDL, TA, and plantaris muscles, of senescence-accelerated mouse-prone 1 mice.‍ ( 43 ) In contrast, dietary lycopene up-regulates MyHC I gene expression and down-regulates MyHC IIb gene expression in both soleus and gastrocnemius muscles of mice.‍ ( 44 ) CD36 is required for lycopene uptake in adipocytes and adipose tissue.‍ ( 45 ) The molecular mechanism by which lycopene is incorporated into the gastrocnemius muscle is unknown, but these results suggest that β-carotene, β-cryptoxanthin, and lycopene are incorporated into the soleus muscle via CD36.…”

Section: Discussionmentioning

confidence: 99%

Carotenoid transporter CD36 expression depends on hypoxia-inducible factor-1α in mouse soleus muscles

Kitakaze

Sugihira

Kameyama

et al. 2022

J. Clin. Biochem. Nutr.

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Dietary β-carotene induces muscle hypertrophy and prevents muscle atrophy in red slow-twitch soleus muscles, but not in white fast-twitch extensor digitorum longus (EDL) muscles and gastrocnemius muscles. However, it remains unclear why these beneficial effects of β-carotene are elicited in soleus muscles. To address this issue, we focused on carotenoid transporters in skeletal muscles. In mice, Cd36 mRNA levels were higher in red muscle than in white muscle. The siRNA-mediated knockdown of CD36 decreased β-carotene uptake in C2C12 myotubes. In soleus muscles, CD36 knockdown inhibited β-carotene-induced increase in muscle mass. Intravenous injection of the hypoxia marker pimonidazole produced more pimonidazole-bound proteins in soleus muscles than in EDL muscles, and the hypoxia-inducible factor-1 (HIF-1) α protein level was higher in soleus muscles than in EDL muscles. In C2C12 myotubes, hypoxia increased the expression of CD36 and HIF-1α at the protein and mRNA levels, and HIF-1α knockdown reduced hypoxia-induced increase in Cd36 mRNA level. In soleus muscles, HIF-1α knockdown reduced Cd36 mRNA level. These results indicate that CD36 is predominantly involved in β-carotene-induced increase in soleus muscle mass of mice. Furthermore, we demonstrate that CD36 expression depends on HIF-1α in the soleus muscles of mice, even under normal physiological conditions.

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“…BCX is a natural antioxidant that functions as an antiinflammation and anticancer agent [ 36 ]. A recent study noted that BCX improved muscle atrophy in the senescence-accelerated mouse-prone 1 mice, suggesting that BCX had anti-senescence effects [ 37 ]. In this study, we found that BCX reduced the number of SA-β-gal-positive cells, inhibited the expression of P16, P21, and P53, and reduced the production of the cellular senescence marker γ-H2AX in HK-2 cells.…”

Section: Discussionmentioning

confidence: 99%

β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells

Zhang

Mao

et al. 2023

IJMS

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The mechanisms of acute kidney injury and chronic kidney disease remain incompletely revealed, and drug development is a pressing clinical challenge. Oxidative stress-induced cellular senescence and mitochondrial damage are important biological events in a variety of kidney diseases. As a type of carotenoid, β-Cryptoxanthin (BCX) has various biological functions, which means it is a potential therapeutic candidate for the treatment of kidney disease. However, the role of BCX in the kidney is unclear, and the effect of BCX on oxidative stress and cellular senescence in renal cells is also unknown. Therefore, we conducted a series of studies on human renal tubular epithelial (HK-2) cells in vitro. In the present study, we investigated the effect of BCX pretreatment on H2O2-induced oxidative stress and cellular senescence and explored the potential mechanism of BCX action. The results showed that BCX attenuated H2O2-induced oxidative stress and cellular senescence in HK-2 cells. Moreover, BCX promoted NRF2 nuclear expression, maintained mitochondrial function, and reduced mitochondrial damage in HK-2 cells. In addition, silencing NRF2 altered the protective effect of BCX on mitochondria and significantly reversed the anti-oxidative stress and anti-senescence effects of BCX in HK-2 cells. We concluded that BCX maintained mitochondrial function by promoting NRF2 nuclear translocation to inhibit oxidative stress-induced senescence in HK-2 cells. In light of these findings, the application of BCX might be a promising strategy for the prevention and treatment of kidney diseases.

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β-Cryptoxanthin Improves p62 Accumulation and Muscle Atrophy in the Soleus Muscle of Senescence-Accelerated Mouse-Prone 1 Mice

Cited by 6 publications

References 39 publications

A Comprehensive Review of Pathological Mechanisms and Natural Dietary Ingredients for the Management and Prevention of Sarcopenia

A Comprehensive Review of Pathological Mechanisms and Natural Dietary Ingredients for the Management and Prevention of Sarcopenia

Carotenoid transporter CD36 expression depends on hypoxia-inducible factor-1α in mouse soleus muscles

β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells

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