β-Cyclodextrin Assisted Liquid–Liquid Microextraction Based on Solidification of the Floating Organic Droplets Method for Determination of Neonicotinoid Residues

Abstract

An efficient and environment-friendly microextraction method, namely, β-cyclodextrin assisted liquid–liquid microextraction, based on solidification of the floating organic droplets method coupled with HPLC is investigated for the sensitive determination of trace neonicotinoid pesticide residues. In this method, β-cyclodextrin is used as a disperser solvent, while 1-octanol is selected as an extraction solvent. β-cyclodextrins was found to decrease interfacial tension and increase the contact area between the organic and water phases with the help of centrifugation. A cloudy solution was rapidly formed and then centrifuged to complete phase separation. Various key parameters influencing extraction efficiency were systematically investigated and optimized; they include salt addition, concentration of β-cyclodextrin, and volume of extraction solvent (1-octanol). Under optimum conditions, good linearity was obtained with coefficient for determination (R2) greater than 0.99. A low limit of detection, high enrichment factor, and good recovery (83 – 132) were achieved. This proves that the proposed method can be applied to determine trace neonicotinoid pesticide residues in natural surface water samples.

Progress in host–guest macrocycle/pesticide research: Recognition, detection, release and application

“…Vichapong et al reported a microextraction method for the detection of the neonicotinoid pesticides thiamethoxam, clothianidin, imidacloprid, acetamiprid and thiacloprid. [126] The system was based on β-cyclodextrin assisted liquid-liquid microextraction, which involved a solidification process (of floating droplets) in combination with HPLC. The presence of the βcyclodextrin (disperser solvent) aided, along with centrifugation, the process by increasing the organic and aqueous phase contact area, whilst at the same time reducing the interfacial tension.…”

Reviewing neonicotinoid detection with electroanalytical methods

“…To date, numerous sample preparation methods for analysis have been developed. These include liquid–liquid extraction (Timofeeva et al 2017 ), liquid phase microextraction (Vichapong et al 2013 , 2019 ; Kachangoon et al 2020a , 2020b ), solid-phase extraction (Wang et al 2020b ; Zaidon et al 2019 ; Ghiasi et al 2020 ), QuEChERS (Paradis et al 2014 ; Tanner and Czerwenka 2011 ), and anion exchange-disposable pipette extraction (Song et al 2018 ). Following sample preparation, the next essential step is selecting the appropriate analytical method.…”

Rapid analysis of triazine herbicides in fruit juices using evaporation-assisted dispersive liquid–liquid microextraction with solidification of floating organic droplets and HPLC-DAD

“…9,10 In DLLME, a combination of extractant and dispersive solvent is swily injected into the aqueous sample phase to generate a cloudy solution. 11 This results in faster extraction times, 12 due to its simplicity, 13 yields high enrichment factors and can easily be combined with other analytical method. DLLME thus has certain advantages over the classic methods of pretreatment.…”