β-Cyclodextrin-based chiral nanocomposite for thin-layer chromatographic detection of enantiomers of fluoxetine

Bhardwaj, Shruti; Vashistha, Vinod Kumar

doi:10.1007/s00764-022-00161-9

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…58 Moreover, the nanocomposites of β-CD and 3D graphene were introduced into silica slurry for thinlayer chromatography (TLC) separation of fluoxetine enantiomers. 59 Similarly, the racemate of acetylbutanol was separated by TLC with colistin sulfate as the chiral selector. 60 ■ CAPILLARY ELECTROPHORESIS Capillary electrophoresis (CE) remains a popular technique for the enantio-separation of biologically active compounds.…”

Section: ■ Chromatographymentioning

confidence: 99%

“…Simulated moving bed chromatography with chiral stationary phase of amylose tris(5-chloro-2-methylphenylcarbamate) was also applied for chiral separation of amide N -(2-methylbenzyl-phenylglycinamide) . Moreover, the nanocomposites of β-CD and 3D graphene were introduced into silica slurry for thin-layer chromatography (TLC) separation of fluoxetine enantiomers . Similarly, the racemate of acetylbutanol was separated by TLC with colistin sulfate as the chiral selector …”

Section: Chromatographymentioning

confidence: 99%

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Recent Advances in Separation and Analysis of Chiral Compounds

Yan

2023

Anal. Chem.

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Section: ■ Chromatographymentioning

confidence: 99%

Section: Chromatographymentioning

confidence: 99%

Recent Advances in Separation and Analysis of Chiral Compounds

Yan

2023

Anal. Chem.

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“…Extraction of API was performed by employing the method established in the literature 16–18 . Briefly, 10 sivextro tablets (each containing 200 mg of TED) were ground well in a mortar.…”

Section: Methodsmentioning

confidence: 99%

“…Extraction of API was performed by employing the method established in the literature. [16][17][18] Briefly, 10 sivextro tablets (each containing 200 mg of TED) were ground well in a mortar. The powdered material was transferred in a 100-ml volumetric flask containing 250 ml of methanol and sonicated for about 10 min.…”

Section: Extraction Of Active Pharmaceutical Ingredients (Api)mentioning

confidence: 99%

Enantioseparation of linezolid and tedizolid using validated high‐performance liquid chromatographic method

et al. 2022

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This paper reports the separation of two chiral antibacterial agents namely, linezolid and tedizolid using a validated high‐performance liquid chromatographic method. In the current work, glycopeptide‐based chiral column, CHIROBIOTIC® V2 (5‐μm particle size, L × I.D. 25 cm × 4.6 mm) was employed with a mobile phase containing methanol and 0.15% aq. trifluoracetic acid (75:25%, v/v) in isocratic elution approach at flow rate of 1 ml min−1. The separation condition was customized (in terms of resolution values and retention times) was carried out by changing the content of the mobile phase, column temperature, flow rate, and so on. Results showed that the chromatographic separation was achieved within 15 min and average resolution values were 4.6 and 4.8 for tedizolid and linezolid, respectively. The detection limit values were 14.85 and 14.16 ng ml−1, respectively, for tedizolid enantiomers. Further, validation of separation parameters was performed by considering the international conference on harmonization guidelines, and ultimately, the mechanism of chiral recognition was also established.

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Chiral Analysis of Pharmaceuticals Using NMR Spectroscopy: A Review

Vashistha

2022

Asian J Org Chem

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Chirality recognition of pharmaceutical products plays a significant part in asymmetric synthesis, stereoselective catalysis, supramolecular chemistry, and the development of new drug substances. NMR spectroscopy is a potential technique utilized not only for the determination of chemical structure but also for chirality analysis. Three main approaches are developed for the assessment of the chirality of organic compounds through NMR spectroscopy that depends on the use of chiral discriminating agents such as chiral solvating agents, and chiral derivatizing agents. This article highlights the recent advances in chiral recognition of pharmaceutically important compounds using NMR spectroscopic methods.

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β-Cyclodextrin-based chiral nanocomposite for thin-layer chromatographic detection of enantiomers of fluoxetine

Cited by 7 publications

References 21 publications

Recent Advances in Separation and Analysis of Chiral Compounds

Recent Advances in Separation and Analysis of Chiral Compounds

Enantioseparation of linezolid and tedizolid using validated high‐performance liquid chromatographic method

Chiral Analysis of Pharmaceuticals Using NMR Spectroscopy: A Review

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