β-Cyclodextrin grafted polyethyleneimine hydrogel immobilizing hydrophobically modified glucose oxidase

Synthesis of polyethyleneimine (PEI) and β‐cyclodextrin grafted PEI nanocomposites with magnetic cores for lipase immobilization and esterification

“…(h)) proved the formation of an amide bond between HMDI and β ‐CD. In addition, the major peaks of β ‐CD at 1075–1110 cm −1 and 1750 cm −1 related to the stretching of the C–O and C–O–C groups in the prepared Fe 3 O 4 MNPs@PEI/HMDI/ β ‐CD and Fe 3 O 4 MNPs@HA/PEI/HMDI/ β ‐CD could be seen in the FTIR spectra of the aforementioned species (Fig. (g) and Fig.…”

“…The presence of PEI in the structure of PEI‐containing nanocomposites could be ascribed to C–H bonds (2896–2933 cm −1 ), N–H bonds (1541–1574 cm −1 ), and NH stretching (3320–3550 cm −1 ) in the related FTIR spectra (Fig. (c)–(h)) . Two strong peaks at 1730 cm −1 and 2270–2280 cm −1 , which are characteristic of the carbonyl group (N–C = O) and the isocyanate group (−N = C = O), can be observed from the FTIR spectra of HMDI‐containing nanocomposites (Fig.…”

Recent advances in glucose-oxidase-based nanocomposites for diabetes diagnosis and treatment

“…At glucose concentrations of 0–100 mg dL −1 , the swelling rate of the hydrogel increased from 960% to 119% within 24 h, with a significant increase in the release of the contents. 76 In acid-sensitive hydrogels, H 2 O 2 , a by-product of the enzymatic reaction, can inhibit the swelling or shrinking of the hydrogel. Therefore, in GOx hydrogel systems, peroxidase is usually incorporated to increase sensitivity to the environment.…”

Glucose Oxidase-Based Glucose-Sensitive Drug Delivery for Diabetes Treatment

“…Besides CS, cyclodextrin (CD) has become the focus of scientific research in drug delivery systems. A pH-responsive tosyl- β -CD-grafted polyethyleneimine (PEI- β CD) hydrogels cross-linked by epichlorohydrin (EPI) was successfully prepared [55]. Hydrophobically modified GOD (HmGOD) was successfully immobilized into the hydrogels.…”