β-Elemene inhibits the metastasis of multidrug-resistant gastric cancer cells through miR-1323/Cbl-b/EGFR pathway

Deng, Mingming; Liu, Bofang; Song, Hongli; Yu, Ruoxi; Zou, Dan; Chen, Yang; Ma, Yanju; Lv, Fei; Xu, Ling; Zhang, Zhe; Lv, Qing; Yang, Xianghong; Che, Xiaofang; Qu, Xiujuan; Liu, Yunpeng; Zhang, Ye; Hu, Xuejun

doi:10.1016/j.phymed.2020.153184

Cited by 56 publications

(41 citation statements)

References 40 publications

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“…31 β-Elemene was also found to reverse epithelialmesenchymal transition (EMT) in MDR gastric cancer cells by inhibiting the transcription factors ZEB1 and ZEB2 that contribute to antitumor metastatic activities. 25 Moreover, the radiation-induced HIF1α and peroxiredoxin-1 (Prx-1) expression were significantly suppressed by β-elemene, which reversed the radio-resistance of the human lung cancer. 27,28 Besides β-elemene, curcumol, diterpenoid C and tetrahydrocurcumin, identified from Curcumae radix, were also reported to demonstrate anticancer effects in vitro and in vivo.…”

Section: N-butyl Alcohol Extracts Ofmentioning

confidence: 99%

“…34 Recent studies have reported that β‐elemene significantly inhibited the migration and invasive capacity of BGC823, SGC7901 and multidrug resistant (MDR) SGC7901/ADR gastric cancer cells, TE-1 and KYSE-150 esophageal cancer cells in vitro and inhibited the capacity of BGC823 cells to diffuse peritoneally and metastasize in vivo. 24,25,31 Moreover, the radio sensitivity of cancers, such as glioblastoma multiforme U87-MG, T98G, and U251 cells, 32 melanoma A375 cells, 44 and A549 lung adenocarcinoma xenograft 27,28 were also reported to be significantly enhanced by β-elemene.…”

Section: Pharmacologymentioning

confidence: 99%

“…26,27,29,33,35,37 In addition, β-elemene performed synergistic or directly suppressive effects through targeting histone H1, 23 copper transporter 1 (CTR1), 30 E3 ubiquitin ligase Cbl, 36 signal transducer, and activator of transcription 3 (Stat3), DNA methyltransferase 1 (DNMT1), enhancer of zeste homolog 2 (EZH2), 34 hypoxia inducible factor 1 subunit α (HIF1α), vascular endothelial growth factor A (VEGFA), 39 PTEN, 31 and ataxia telangiectasia mutated (ATM) signaling pathways. 32 Furthermore, β-elemene inhibited tumor angiogenesis and metastasis through regulation of crucial molecules, such as Claudin-1 by downregulating FAK phosphorylation, 24 MMP-2/9 via modulating Cbl-b/EGFR/ERK/AKT signaling 25 and programmed cell death 1-ligand 1 (PD-L1) by regulating p-AKT. 31 β-Elemene was also found to reverse epithelial-mesenchymal transition (EMT) in MDR gastric cancer cells by inhibiting the transcription factors ZEB1 and ZEB2 that contribute to antitumor metastatic activities.…”

Section: Pharmacologymentioning

confidence: 99%

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A Comprehensive Mini-Review of Curcumae Radix: Ethnopharmacology, Phytochemistry, and Pharmacology

Gao

Yang

et al. 2021

Natural Product Communications

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Curcumae Radix is an efficacious ingredient with various medicinal properties empirically used in traditional Chinese medicine (TCM) formula for the treatment of cancer, depression, chest pain, dysmenorrhea, epilepsy, and jaundice. However, either phytochemical or pharmacological information of Curcumae Radix underlying its traditionally medicinal uses is rarely summarized and systematically analyzed. To provide evidence for clinical trials, a comprehensive literature review has been prepared of the phytochemicals, and ethnopharmacological and pharmacological mechanisms of this herb. The review approach consisted of searching several web-based scientific databases, including PubMed, Web of Science, and Elsevier. The keywords included “Curcumae Radix,” “ Curcuma wenyujin,” “ Curcuma longa,” “ Curcuma kwangsiensis,” and “ Curcuma phaeocaulis.” Based on the proposed criteria, 57 articles were evaluated in detail. The accumulated data indicate that Curcumae Radix contains a number of bioactive phytochemicals, mainly sesquiterpenes, diarylheptanoids, and diarylpentanoids, which account for a variety of medicinal values, such as anticancer, anti-inflammation, anti-hepatic fibrosis, and antioxidant. A wide range of apoptotic proteins, cell adhesion molecules, inflammatory cytokines, and enzymic and nonenzymic antioxidants could be modulated by either Curcumae Radix or its bioactive compounds, thus underpinning a fundamental understanding for the pharmacological effects of this herb. This review highlights the therapeutic potential of Curcumae Radix to progress the development of versatile adjuvants or therapeutic agents in the future.

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Section: N-butyl Alcohol Extracts Ofmentioning

confidence: 99%

Section: Pharmacologymentioning

confidence: 99%

Section: Pharmacologymentioning

confidence: 99%

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A Comprehensive Mini-Review of Curcumae Radix: Ethnopharmacology, Phytochemistry, and Pharmacology

Gao

Yang

et al. 2021

Natural Product Communications

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“…Similarly, it was indicated that β‐element, an anti‐tumor natural agent of traditional Chinese herbal medicine, played an anti‐metastatic role in MDR gastric cancer by suppressing the expression of matrix metalloproteinase (MMP)2 and MMP9 following suppression of the EGFR–ERK/AKT pathways mediated by Cbl‐b up‐regulation. It was found that β‐element can suppress miR‐1323 and subsequent up‐regulate Cbl‐b expression, which paves the way to EGFR ubiquitination and degradation by Cbl‐b [153]. Consequently, these data clearly illustrate the Cbl‐b role in the prevention of tumor metastasis, mainly through keeping the epithelial phenotype in MDR breast and gastric cancer cells [150,152].…”

Section: Cbl‐b In Immune‐related Diseasesmentioning

confidence: 99%

E3 ubiquitin ligase Casitas B lineage lymphoma-b and its potential therapeutic implications for immunotherapy

Jafari

Mousavi

Shahbaz

et al. 2021

Clinical and Experimental Immunology

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Summary The distinction of self from non‐self is crucial to prevent autoreactivity and ensure protection from infectious agents and tumors. Maintaining the balance between immunity and tolerance of immune cells is strongly controlled by several sophisticated regulatory mechanisms of the immune system. Among these, the E3 ligase ubiquitin Casitas B cell lymphoma‐b (Cbl‐b) is a newly identified component in the ubiquitin‐dependent protein degradation system, which is thought to be an important negative regulator of immune cells. An update on the current knowledge and new concepts of the relevant immune homeostasis program co‐ordinated by Cbl‐b in different cell populations could pave the way for future immunomodulatory therapies of various diseases, such as autoimmune and allergic diseases, infections, cancers and other immunopathological conditions. In the present review, the latest findings are comprehensively summarized on the molecular structural basis of Cbl‐b and the suppressive signaling mechanisms of Cbl‐b in physiological and pathological immune responses, as well as its emerging potential therapeutic implications for immunotherapy in animal models and human diseases.

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“…β-Elemene extracted from Chinese herbal medicine showed a good effect on the inhibition of metastasis in nude mice. Deng et al [ 67 ] confirmed that β-elemene suppressed miR-1323 and up-regulated casitas B lymphoma-b (Cbl-b) expression to achieve these results.…”

Section: Invasion and Metastasismentioning

confidence: 99%

Recent advances of miRNAs in the development and clinical application of gastric cancer

Shi

2020

Chinese Medical Journal

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Gastric cancer (GC) is one of the most common malignant tumors. The mechanism of how GC develops is vague, and therapies are inefficient. The function of microRNAs (miRNAs) in tumorigenesis has attracted the attention from many scientists. During the development of GC, miRNAs function in the regulation of different phenotypes, such as proliferation, apoptosis, invasion and metastasis, drug sensitivity and resistance, and stem-cell-like properties. MiRNAs were evaluated for use in diagnostic and prognostic predictions and exhibited considerable accuracy. Although many problems exist for the application of therapy, current studies showed the antitumor effects of miRNAs. This paper reviews recent advances in miRNA mechanisms in the development of GC and the potential use of miRNAs in the diagnosis and treatment of GC.

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β-Elemene inhibits the metastasis of multidrug-resistant gastric cancer cells through miR-1323/Cbl-b/EGFR pathway

Cited by 56 publications

References 40 publications

A Comprehensive Mini-Review of Curcumae Radix: Ethnopharmacology, Phytochemistry, and Pharmacology

A Comprehensive Mini-Review of Curcumae Radix: Ethnopharmacology, Phytochemistry, and Pharmacology

E3 ubiquitin ligase Casitas B lineage lymphoma-b and its potential therapeutic implications for immunotherapy

Recent advances of miRNAs in the development and clinical application of gastric cancer

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