β-Glucan-enriched bread reduces energy intake and modifies plasma ghrelin and peptide YY concentrations in the short term

Vitaglione, Paola; Lumaga, Roberta Barone; Stanzione, Antonio; Scalfi, Luca; Fogliano, Vincenzo

doi:10.1016/j.appet.2009.07.013

Cited by 128 publications

(96 citation statements)

References 47 publications

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“…The consumption of soluble fibre has been associated with increased levels of circulating PYY (Beck 2010;Karhunen et al 2010;Vitaglione et al 2009), and it has been shown that PYY acts to inhibit gastric mobility and acid secretion (Huda et al 2006). Furthermore, evidence strongly suggests that PYY stimulates jejuna apolipoprotein A-IV synthesis and secretion (Tso et al 2004;Kalogeris et al 1998), and this apolipoprotein is involved in triglyceriderich lipoprotein metabolism (Hockey et al 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, several studies have shown that consumption of soluble fibre increases the production of gut peptides, including PYY (Beck 2010;Karhunen et al 2010;Vitaglione et al 2009). Moreover, it has been described that these peptides act in the hypothalamus by disabling NPY release (Roux and Bloom 2005;Batterham et al 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Studies with humans and animals have shown that soluble fibre consumption is associated with altered circulating levels of the anorexigenic gut hormone peptide YY (PYY) (Beck 2010;Karhunen et al 2010;Vitaglione et al 2009) and of the adipocyte-released anorexigenic peptide leptin (Young et al 2012;Artiss et al 2006). Furthermore, it has been demonstrated that PYY and leptin act on the hypothalamus, influencing the expression of some central signals such as the orexigenic peptide neuropeptide Y (NPY) (Roux and Bloom 2005;Batterham et al 2002;Jequier 2002).…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms in LEP and NPY genes modify the response to soluble fibre Plantago ovata husk intake on cardiovascular risk biomarkers

et al. 2012

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The satiating effect of fibre consumption has been related to gut hormones, such as peptide YY and leptin. These peptides may also influence cardiovascular (CVD) risk biomarkers. Nevertheless, there is wide interindividual variation in metabolic responses to fibre consumption. The objective was to investigate differences in the effects of soluble fibre, in the form of Plantago ovata husk (Po-husk) treatment, on CVD risk biomarkers according to selected polymorphisms in genes related to satiety. The study was a multi-centred, double-blind, placebo-controlled, parallel and randomised trial in mildmoderate hypercholesterolaemic patients (age range: 43-67 years). Eight polymorphisms in three genes related to satiety (LEP, NPY and PYY) were identified in 178 participants; 88 patients in the placebo (microcrystalline cellulose 14 g/day) group and 90 in the Po-husk (14 g/day) group, which had added to a low-saturated-fat diet for 8 weeks. The CVD biomarkers measured included the following: lipid profile, blood pressure (BP), glucose, insulin, hs-CRP, oxidised LDL and IL-6. Relative to the placebo, Po-husk consumption lowered the plasma total cholesterol concentration by 3.3 % according to rs7799039 polymorphism in the LEP gene (p \ 0.05). Furthermore, the Po-husk reduced systolic BP (mean [95 % CI]) by -8 mmHg (-14.16; -1.90) and hs-CRP by 24.9 % in subjects with the AA genotype of the rs16147 polymorphism in the NPY gene (32 % of our total population; p \ 0.05), which remained significant after Bonferroni correction. In conclusion, polymorphisms in the LEP and NPY genes potentiate the response to Po-husk, particularly the effects on systolic BP and the hs-CRP plasma concentration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polymorphisms in LEP and NPY genes modify the response to soluble fibre Plantago ovata husk intake on cardiovascular risk biomarkers

et al. 2012

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“…In a randomized, crossover design, subjects (n=14) consumed isoenergetic breads enriched with 3 g barley β-glucan or control (Vitaglione et al, 2009). Ghrelin AUC60-180 was significantly lower following the fiber treatment.…”

Section: Effect Of Fiber On Ghrelin Concentrationsmentioning

confidence: 99%

“…Two studies used randomized, crossover designs and controls matched for calories and macronutrients. The first measured 3 g barley β-glucan in 14 normal weight volunteers (Vitaglione, Lumaga, Stanzione, Scalfi & Fogliano, 2009). Area under the curve (AUC) measured over 3 hours was significantly higher following β-glucan intake compared to control.…”

Section: Effect Of Fiber On Peptide Yy Concentrationsmentioning

confidence: 99%

Fiber intake Inconsistently Alters Gut Hormone Levels in Humans Following Acute or Chronic Intake

Klosterbuer¹,

Greaves²,

Slavin

2012

JFR

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Diet composition affects the release of gut hormones involved in the regulation of appetite and energy intake. While some research suggests high fiber foods cause greater satiety than low fiber foods, few studies have measured gut hormone levels as a mechanism by which fiber may influence appetite. A review of the literature was conducted to better understand the effect of fiber on gut hormone concentrations in humans, which specific focus on peptide YY, glucagon-like peptide-1, cholecystokinin, and ghrelin. Considerable variation was found in study design, population, fiber type and level. Few studies reported a significant effect of fiber on gut hormone levels, and data suggest caloric load may have a more significant influence on gut hormone release. While it is possible that circulating gut hormones are not the mechanism by which fibers influence satiety, it is also possible that variability in study design prevents definitive conclusions around this relationship.

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Oat β‐Glucans: Physicochemistry and Nutritional Properties

Kale

Hamaker

Bordenave

2013

Oats Nutrition and Technology

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β-Glucan-enriched bread reduces energy intake and modifies plasma ghrelin and peptide YY concentrations in the short term

Cited by 128 publications

References 47 publications

Polymorphisms in LEP and NPY genes modify the response to soluble fibre Plantago ovata husk intake on cardiovascular risk biomarkers

Polymorphisms in LEP and NPY genes modify the response to soluble fibre Plantago ovata husk intake on cardiovascular risk biomarkers

Fiber intake Inconsistently Alters Gut Hormone Levels in Humans Following Acute or Chronic Intake

Oat β‐Glucans: Physicochemistry and Nutritional Properties

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