β-hydroxybutyrate reduces reinstatement of cocaine conditioned place preference through hippocampal CaMKII-α β-hydroxybutyrylation

Li, Hongchun; Wan, Xuemei; Wu, Zhixiang; Zhou, Yuanyi; Chen, Rong; Xu, Wei; Zhang, Jiamei; Bai, Lin; Zhang, Jie; Qin, Feng; Wang, Liang; Chen, Yaxing; Jiang, Linhong; He, Yuman; Wang, Xiaojie; Wei, Qian; Li, Shu; Dai, Yanping; Chen, Yuanyuan; Wang, Yonghai; Wang, Hongbo; Tian, Jingwei; Zhao, Yinglan; Cen, Xiaobo

doi:10.1016/j.celrep.2022.111724

Cited by 10 publications

(2 citation statements)

References 54 publications

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“…Histones and recombinant ACSS2 protein (RPD672Mu01, CLOUD-CLONE) were incubated in βhydroxybutyrylation buffer (25 mM Tris-HCl pH 8.0, 100 mM NaCl, 1 mM DTT, 100 μM EDTA, 5 μm CoA,10% glycerol, protease inhibitor cocktail, 10 mM NAM and 100 ng/mL TSA) at 37 °C for 2 h 47 . The rest steps are the same as in vitro nicotinylation.…”

Section: Dna Pull-downmentioning

confidence: 99%

Nicotinic acid suppresses liver cancer metastasis via histone lysine nicotinylation

Zhang,

Jiang,

et al. 2024

Preprint

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Vitamin B3 is the major precursor of NAD+ and NADP+, however it was unknown whether this vitamin supplementation could modify histone epigenetically. Here, we report nicotinic acid (NA), a component of vitamin B3, suppresses liver cancer metastasis specifically, via stimulating histone lysine nicotinylation (Knic). Importantly, nicotinyl-CoA, that metabolically generated by NA via ACSS2, stimulates histone Knic in vivo and in vitro. Histone Knic regulates chromatin accessibility and inhibits binding of transcription factor HOXB9 to the promoter of oncogene PPFIA1, resulting in inhibition of hepatocyte carcinoma progression. Notably, we found that NA specific induces histone Knic and suppresses hepatocyte carcinoma progression, whereas nicotinamide, an amide form of nicotinic acid, does not stimulate nicotinylation, instead promotes tumour growth and metastasis. These findings suggest that vitamin B3 supplementation may contribute to cancer progression depending on its composition. Collectively, we demonstrated that histone lysine nicotinylation is a histone mark controlling gene expression and NA supresses liver cancer progression by inducing histone lysine nicotinylation.

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Section: Dna Pull-downmentioning

confidence: 99%

Nicotinic acid suppresses liver cancer metastasis via histone lysine nicotinylation

Zhang,

Jiang,

et al. 2024

Preprint

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“…In mouse models of depression, H3K9bhb is reduced, and KD or BHB administration exerts antidepressant effects by increasing H3K9bhb levels and BDNF expression, linking BHB and BDNF via H3K9bhb [ 157 ]. A recent study revealed that KD consumption and BHB treatment in rats reduced cocaine-induced reinstatement through beta-hydroxybutyrylation of CaMKIIα in the hippocampus [ 158 ]. Beta-hydroxybutyrylation of CaMKIIα inhibited phosphorylation and activity of CaMKIIα.…”

Section: Molecular Mechanisms Of the Neuroprotective Effects Of Kbs A...mentioning

confidence: 99%

Molecular Mechanisms of Neuroprotection by Ketone Bodies and Ketogenic Diet in Cerebral Ischemia and Neurodegenerative Diseases

Jang,

Kim,

Lee

et al. 2023

IJMS

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Ketone bodies (KBs), such as acetoacetate and β-hydroxybutyrate, serve as crucial alternative energy sources during glucose deficiency. KBs, generated through ketogenesis in the liver, are metabolized into acetyl-CoA in extrahepatic tissues, entering the tricarboxylic acid cycle and electron transport chain for ATP production. Reduced glucose metabolism and mitochondrial dysfunction correlate with increased neuronal death and brain damage during cerebral ischemia and neurodegeneration. Both KBs and the ketogenic diet (KD) demonstrate neuroprotective effects by orchestrating various cellular processes through metabolic and signaling functions. They enhance mitochondrial function, mitigate oxidative stress and apoptosis, and regulate epigenetic and post-translational modifications of histones and non-histone proteins. Additionally, KBs and KD contribute to reducing neuroinflammation and modulating autophagy, neurotransmission systems, and gut microbiome. This review aims to explore the current understanding of the molecular mechanisms underpinning the neuroprotective effects of KBs and KD against brain damage in cerebral ischemia and neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease.

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Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation

Li,

Liuha,

Chen

et al. 2024

Cell Reports

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β-hydroxybutyrate reduces reinstatement of cocaine conditioned place preference through hippocampal CaMKII-α β-hydroxybutyrylation

Cited by 10 publications

References 54 publications

Nicotinic acid suppresses liver cancer metastasis via histone lysine nicotinylation

Nicotinic acid suppresses liver cancer metastasis via histone lysine nicotinylation

Molecular Mechanisms of Neuroprotection by Ketone Bodies and Ketogenic Diet in Cerebral Ischemia and Neurodegenerative Diseases

Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation

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