β-Klotho Promotes the Development of Intrauterine Adhesions via the PI3K/AKT Signaling Pathway

Guo, Zizhen; Wang, Yuqing; Wen, Xin; Xu, Xinxin; Liu, Yan

doi:10.3390/ijms231911294

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…Pi3k and Akt are mainly expressed in inflammatory cells, vascular endothelial cells, and fibroblasts in the basal layer, spinous layer, and epithelial submucosa 10,11 . Limited Pi3k and Akt were observed in normal tissues (Figure 1E,F).…”

Section: Resultsmentioning

confidence: 98%

“…Pi3k and Akt are mainly expressed in inflammatory cells, vascular endothelial cells, and fibroblasts in the basal layer, spinous layer, and epithelial submucosa. 10,11 Limited Pi3k and Akt were observed in normal tissues (Figure 1E,F). In early stage OSF tissues, high levels of Pi3k and Akt expression are observed in the epithelial basal layer and submucosa.…”

Section: Inflammation and Collagen Level Increase As Osf Developsmentioning

confidence: 95%

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Expression and correlation of the Pi3k/Akt pathway and VEGF in oral submucous fibrosis

et al. 2023

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Oral submucous fibrosis (OSF) has a high incidence in Asia countries, but its underlying molecular mechanism was not exploited completely. In this research, we investigated the expression of the phosphatidyl inositol 3‐kinase (Pi3k)/protein kinase B (Akt) pathway and vascular endothelial growth factor (VEGF) in oral submucosal fibrosis, explore the correlation between the Pi3k/Akt pathway and VEGF, and identify the mechanisms involved in OSF. The pathological changes and fibrosis stages of OSF tissues (n = 30, 10 each of early, moderate and advanced OSF) were determined using Haematoxylin–eosin staining (HE) and Masson staining, respectively. Collagen type I (Col‐I), Pi3k, Akt, VEGF, TGF‐β and p‐Akt expression was detected using immunohistochemistry, qPCR and WB. The correlation between Pi3k, Akt and VEGF was analysed. Col‐I expression increased as OSF progressed. However, their expression was downregulated in normal and moderate to advanced OSF tissues. VEGF expression positively correlated with Pi3k and Akt expression. VEGF expression correlated positively and negatively with the Pi3k inhibitor, LY294002 below and above a concentration of 10 μM, respectively. VEGF expression correlated positively with the Pi3k/Ak activator, IGF‐1. Due to the synergistic effect between Pi3k/Akt pathway and VEGF on OSF lesions and fibrosis process, targeted Pi3k/Akt pathway regulation can induce VEGF expression and improve ischemia, ultimately treating OSF.

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Section: Resultsmentioning

confidence: 98%

Section: Inflammation and Collagen Level Increase As Osf Developsmentioning

confidence: 95%

Expression and correlation of the Pi3k/Akt pathway and VEGF in oral submucous fibrosis

et al. 2023

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“…Intrauterine adhesions caused by endometrial curettage or infection have been suggested to cause infertility [35]. If the basal layer of the endometrium is damaged during curettage, inflammation is triggered during the wound-healing process [36,37]. Patients with healed chronic endometritis have higher pregnancy and live birth rates than those with persistent inflammation [11]; therefore, healed inflammation in the uterus is important for improving pregnancy rates.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Rates after Hysteroscopic Endometrial Polypectomy versus Endometrial Curettage Polypectomy: A Retrospective Study

Nishioka,

Maezawa,

Takeuchi

et al. 2023

Medicina

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Background and Objectives: A relationship between endometrial polypectomy and in vitro fertilization (IVF) pregnancy outcomes has been reported; however, only a few studies have compared polyp removal techniques and pregnancy rates. We investigated whether different polypectomy techniques with endometrial curettage and hysteroscopic polypectomy for endometrial polyps affect subsequent pregnancy outcomes. Materials and Methods: Data from 434 patients who had undergone polypectomy for suspected endometrial polyps using transvaginal ultrasonography before embryo transfer in IVF at four institutions between January 2017 and December 2020 were retrospectively analyzed. Overall, there were 157 and 277 patients in the hysteroscopic (mean age: 35.0 years) and curettage (mean age: 37.3 years) groups, respectively. Single-blastocyst transfer cases were selected from both groups and age-matched to unify background factors. Results: In the single-blastocyst transfer cases, 148 (mean age: 35.0 years) and 196 (mean age: 35.9 years) were in the hysteroscopic and curettage groups, respectively, with the 148 cases matched by age. In these cases, the pregnancy rates for the first embryo transfer were 68.2% (odds ratio (OR): 2.14) and 51.4% (OR: 1.06) in the hysteroscopic and curettage groups, respectively; the resulting OR was 2.03. The pregnancy rates after up to the second transfer were 80.4% (OR: 4.10) and 68.2% (OR: 2.14) in the hysteroscopic and curettage groups, respectively, in which the OR was 1.91. The live birth rates were 66.2% (OR: 1.956) and 53.4% (OR: 1.15) in the hysteroscopic and curettage groups, respectively, in which the odds ratio was 1.71. These results show the effectiveness of hysteroscopic endometrial polypectomy compared to polypectomy with endometrial curettage. No significant difference was found regarding the miscarriage rates between the two groups. Conclusions: Hysteroscopic endometrial polypectomy resulted in a higher pregnancy rate in subsequent embryo transfer than polypectomy with endometrial curettage. Therefore, establishing a facility where polypectomy can be performed hysteroscopically is crucial.

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Integrating Network Pharmacology and In Vitro Experimental Verification Revealing Bushenhuoxue Recipe Against Intrauterine Adhesions via PI3K-AKT Signaling Pathway

Wang,

Zhuang,

et al. 2024

Biochem Genet

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β-Klotho Promotes the Development of Intrauterine Adhesions via the PI3K/AKT Signaling Pathway

Cited by 6 publications

References 44 publications

Expression and correlation of the Pi3k/Akt pathway and VEGF in oral submucous fibrosis

Expression and correlation of the Pi3k/Akt pathway and VEGF in oral submucous fibrosis

Pregnancy Rates after Hysteroscopic Endometrial Polypectomy versus Endometrial Curettage Polypectomy: A Retrospective Study

Integrating Network Pharmacology and In Vitro Experimental Verification Revealing Bushenhuoxue Recipe Against Intrauterine Adhesions via PI3K-AKT Signaling Pathway

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