β-Lactam antibiotics and antibiotic resistance in Asian lakes and rivers: An overview of contamination, sources and detection methods

Recent Trends in the Development of Carbon-Based Electrodes Modified with Molecularly Imprinted Polymers for Antibiotic Electroanalysis

“…On the other hand, many antibiotics present growth-promoting effects at sub-therapeutic dose levels [15], thus being used as growth promoters in the livestock and aquaculture industries [18,24]. Antibiotics were seldom applied in crop production (e.g., in China) [25] and sometimes (e.g., CAP) as a disinfectant agent in aquaculture to prevent diseases [26]. The extensive use of antibiotics is argued by the fact that only the macrolide antibiotics market reached worldwide sales of billions of dollars [27], while around 63,150 tons of antibiotics are consumed alone in the veterinary sector, the global use of antimicrobials in animals being double compared to humans [28].…”

“…Antibiotic residues can exist in the food chain and can accumulate in foodstuffs [30], mainly as a result of their administration to food-producing animals [31], but also due to their addition to dairy products as chemical preservatives (e.g., tetracycline) [32]. Antibiotics can enter the environment directly from the pharmaceutical producers (including research laboratories and industrial production) as contaminated wastewaters or after their use in human or veterinary medicine (excreted through urine and feces or discarded as domestic or hospital waste) [6] or from agricultural activities (e.g., runoff from agricultural land and from animal farms, soils enriched with manure) [5,15,25], including aquaculture [26]. Antibiotics' concentration decreases from the point sources (e.g., the wastewater treatment plants' effluents) to the receiving waters (e.g., river or lake) due to an environmental attenuation mechanism, which includes dilution, hydrolysis, photolysis by the natural solar radiation, and sorption on suspended particles and sediments [25].…”

“…Antibiotics can enter the environment directly from the pharmaceutical producers (including research laboratories and industrial production) as contaminated wastewaters or after their use in human or veterinary medicine (excreted through urine and feces or discarded as domestic or hospital waste) [6] or from agricultural activities (e.g., runoff from agricultural land and from animal farms, soils enriched with manure) [5,15,25], including aquaculture [26]. Antibiotics' concentration decreases from the point sources (e.g., the wastewater treatment plants' effluents) to the receiving waters (e.g., river or lake) due to an environmental attenuation mechanism, which includes dilution, hydrolysis, photolysis by the natural solar radiation, and sorption on suspended particles and sediments [25]. Nevertheless, the improvements brought to the antibiotic stability resulted in both their persistence for a long time and accumulation in the environment [15].…”

Engineering and functional characterization of a proton-driven β-lactam antibiotic translocation module for bionanotechnological applications

“…One problem commonly addressed with synthetic biology principles 3 , 5 is the growing threat of contamination of environments by small organic molecules such as drugs and pesticides, which cannot be removed by currently used mechanical or biological wastewater disposal techniques 6 . Especially antibiotics are a growing body of concern, as they lead to a higher occurrence of antibiotic resistant genes in prokaryotic organisms 7 , 8 , which contributes to the formation of multiresistant pathogen strains. A simple molecular system to take up and degrade such pollutants could be a bionanoreactor (Fig.…”

An excellent water-stable 3D Zn-MOF with 8-fold interpenetrated diamondoid topology showing “turn-on/turn-off” luminescent detection of Al3+ and SNT in aqueous media

“…Trivalent aluminum ions (Al 3+ ) and antibiotics pollutants are becoming a serious global problem for harming the ecological environment and human health due to their high toxicity and nondegradability. [1][2][3][4] Al 3+ is one of the common cations that can cause drinking water pollution. The excess Al 3+ entering the human body would lead to severe illnesses including Alzheimer's disease and Parkinson's disease.…”