β-Lactoglobulin and Glycodelin: Two Sides of the Same Coin?

Sawyer, Lindsay

doi:10.3389/fphys.2021.678080

Cited by 13 publications

(14 citation statements)

References 306 publications

(396 reference statements)

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“…PAEP, a glycodelin gene, is connected with immune infiltration. It was identified in one study as an independent significant risk factor for Clear Cell Renal Cell Carcinoma (ccRCC) and as one of the survival predictive prognostic markers for melanoma ( Sawyer, 2021 ; Wu et al, 2021 ; Zeng et al, 2022 ). IDE is a multifunctional protease whose main therapeutic areas are neuronal diseases and metabolism.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Role of M6A-Associated Immune Genes and Cluster-Related Tumor Microenvironment Analysis: A Multi-Omics Practice in Stomach Adenocarcinoma

Luo

Zhang

et al. 2022

Front. Cell Dev. Biol.

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N6-methylandrostenedione (m6A) methylation plays a very important role in the development of malignant tumors. The immune system is the key point in the progression of tumors, particularly in terms of tumor treatment and drug resistance. Tumor immunotherapy has now become a hot spot and a new approach for tumor treatment. However, as far as the stomach adenocarcinoma (STAD) is concerned, the in-depth research is still a gap in the m6A-associated immune markers. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases is extremely important for our research, where we obtained gene mutation, gene expression data and relevant clinical information of STAD patients. Firstly, the samples from GEO were used as external validation groups, while the TCGA samples were divided into a training group and an internal validation group randomly. Using the way of Single factor COX-LASSO- and multi-factor Cox to construct the prognostic model. Then, all samples were subjected to cluster analysis to generate high and low expression groups of immune gene. Meanwhile, we also collected the correlation between these types and tumor microenvironment. On this basis, a web version of the dynamic nomogram APP was developed. In addition, we performed microenvironmental correlation, copy number variation and mutation analyses for model genes. The prognostic model for STAD developed here demonstrated a very strong predictive ability. The results of cluster analysis manifested that the immune gene low expression group had lower survival rate and higher degree of immune infiltration. Therefore, the immune gene low expression group was associated with lower survival rates and a higher degree of immune infiltration. Gene set enrichment analysis suggested that the potential mechanism might be related to the activation of immunosuppressive functions and multiple signaling pathways. Correspondingly, the web version of the dynamic nomogram APP produced by the DynNom package has successfully achieved rapid and accurate calculation of patient survival rates. Finally, the multi-omics analysis of model genes further enriched the research content. Interference of RAB19 was confirmed to facilitate migration of STAD cells in vitro, while its overexpression inhibited these features. The prognostic model for STAD constructed in this study is accurate and efficient based on multi-omics analysis and experimental validation. Additionally, the results of the correlation analysis between the tumor microenvironment and m6Ascore are the basics of further exploration of the pathophysiological mechanism in STAD.

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Section: Discussionmentioning

confidence: 99%

Prognostic Role of M6A-Associated Immune Genes and Cluster-Related Tumor Microenvironment Analysis: A Multi-Omics Practice in Stomach Adenocarcinoma

Luo

Zhang

et al. 2022

Front. Cell Dev. Biol.

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“…GdF blocks premature acrosomal reaction during Fallopian tube migration. GdF is subsequently converted into GdC by the oocyte cumulus cells when a sperm-oocyte contact is established, removing GdF inhibition ( Sawyer, 2021 ).…”

Section: Fertilization and Siasmentioning

confidence: 99%

Diversity of sialic acids and sialoglycoproteins in gametes and at fertilization

Fliniaux

Marchand²,

Molinaro³

et al. 2022

Front. Cell Dev. Biol.

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Sialic acids are a family of 9-carbon monosaccharides with particular physicochemical properties. They modulate the biological functions of the molecules that carry them and are involved in several steps of the reproductive process. Sialoglycoproteins participate in the balance between species recognition and specificity, and the mechanisms of these aspects remain an issue in gametes formation and binding in metazoan reproduction. Sialoglycoproteins form a specific coat at the gametes surface and specific polysialylated chains are present on marine species oocytes. Spermatozoa are submitted to critical sialic acid changes in the female reproductive tract facilitating their migration, their survival through the modulation of the female innate immune response, and the final oocyte-binding event. To decipher the role of sialic acids in gametes and at fertilization, the dynamical changes of enzymes involved in their synthesis and removal have to be further considered.

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“…The β‐LG has an antioxidative activity, but its potential does not exceed that of vitamin E and probucol 2 . Moreover, β‐LG is an efficient transporter of molecules with antioxidant and anticancer properties, including phenolic compounds, vitamins and many others 1,5–8 …”

Section: Introductionmentioning

confidence: 99%

“…2 Moreover, β-LG is an efficient transporter of molecules with antioxidant and anticancer properties, including phenolic compounds, vitamins and many others. 1,[5][6][7][8] The β-LG is a major component of ruminant milk of most species, except for humans, guinea pigs, rabbits and rodents. Thus, the biological role of β-LG is considered regarding its nutritional profile and/…”

mentioning

confidence: 99%

β‐Lactoglobulin affects the oxidative status and viability of equine endometrial progenitor cells via lncRNA‐mRNA‐miRNA regulatory associations

Data

Marcinkowska

Buś

et al. 2023

J Cellular Molecular Medi

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β-Lactoglobulin (β-LG) is a small globular protein consisting of 162 amino acid residues that belong to lipocalins, which are potential regulators of cellular communication. [1][2][3][4] The β-LG has an antioxidative activity, but its potential does not exceed that of vitamin E and probucol. 2 Moreover, β-LG is an efficient transporter of molecules with antioxidant and anticancer properties, including phenolic compounds, vitamins and many others. 1,[5][6][7][8] The β-LG is a major component of ruminant milk of most species, except for humans, guinea pigs, rabbits and rodents. Thus, the biological role of β-LG is considered regarding its nutritional profile and/

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β-Lactoglobulin and Glycodelin: Two Sides of the Same Coin?

Cited by 13 publications

References 306 publications

Prognostic Role of M6A-Associated Immune Genes and Cluster-Related Tumor Microenvironment Analysis: A Multi-Omics Practice in Stomach Adenocarcinoma

Prognostic Role of M6A-Associated Immune Genes and Cluster-Related Tumor Microenvironment Analysis: A Multi-Omics Practice in Stomach Adenocarcinoma

Diversity of sialic acids and sialoglycoproteins in gametes and at fertilization

β‐Lactoglobulin affects the oxidative status and viability of equine endometrial progenitor cells via lncRNA‐mRNA‐miRNA regulatory associations

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