β-Sitosterol protects against food allergic response in BALB/c mice by regulating the intestinal barrier function and reconstructing the gut microbiota structure

Abstract

β-Sitosterol, a dietary component, prevents OVA-induced food allergy by ameliorating the intestinal barrier function and reshaping the intestinal microbiota.

Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

“…Anti-inflammatory, antioxidant, anticancer, antibacterial, and fundamental role in memory [92] β -sitosterol Anti-inflammatory, anticancer, hepatoprotective, antioxidant, cardioprotective, antidiabetic, anti-apoptotic and antihistamine…”

“…Anti-inflammatory, antioxidant, anticancer, antibacterial, and fundamental role in memory [92] β-sitosterol and neuronal synthesis. They can inhibit the production biomarkers such as TNF-α, IL-6, IL-17a, and CCL5.…”

Gut–brain communication mediates the impact of dietary lipids on cognitive capacity

“…139 Phytosterols can reshape the gut microbiota, 140 inhibit inflammation and protect the intestinal barrier. 141,142 Dietary β-sitosterol attenuates chronic inflammatory responses induced by high grain feeding in sheep. 143 β-Sitosterol promotes the reproduction of Lactobacillus and Bifidobacterium and decrease of Desulfovibrionaceae , contributing to the improvement of the intestinal microbiota in ovalbumin allergy mice.…”

“…143 β-Sitosterol promotes the reproduction of Lactobacillus and Bifidobacterium and decrease of Desulfovibrionaceae , contributing to the improvement of the intestinal microbiota in ovalbumin allergy mice. 142 Meanwhile, β-sitosterol enhances the intestinal epithelium barrier function and increases secretory IgA in the mucous layer. 142 Moreover, stigmasterol maintains the distribution of the gut microbiota via increasing the abundance of SCFA-producing bacteria Dubosiella and Akkermansia in the gut of mice fed a high cholesterol diet.…”

“…142 Meanwhile, β-sitosterol enhances the intestinal epithelium barrier function and increases secretory IgA in the mucous layer. 142 Moreover, stigmasterol maintains the distribution of the gut microbiota via increasing the abundance of SCFA-producing bacteria Dubosiella and Akkermansia in the gut of mice fed a high cholesterol diet. 140 Dubosiella and Akkermansia can promote the production of SCFAs, and then activate PPARγ to reduce the occurrence of intestinal inflammation to enhance the intestinal barrier function.…”