β<sub>2</sub>Adrenergic Receptor Gene<i>Arg16Gly</i>Polymorphism is Associated with Therapeutic Efficacy of Benazepril on Essential Hypertension in Chinese

Guo, Hao; Huang, Xing; Hao, Ke; Peng, Shaojie; Wu, Di; Guang, Wenwei; Huang, Aiqun; Hong, Xiumei; Wang, Yuanping; Feng, Yan; Zhang, Yan; Li, Jianping; Chen, Changzhong; Zhang, Yuanyuan; Zhang, Xuejun; Li, Dong; Yu, Yunxian; Liu, Jing; Zhu, Guoying; Huo, Yong; Chen, Dafang; Hou, Yongtai; Wang, Xiaobin; Xu, Xin; Niu, Tianhua; Xu, Xiping

doi:10.1081/ceh-200031839

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…Gly16 instead of the Arg16 allele of B2AR has been proved to be a risk for hypertension in humans (7). The B2AR R16G polymorphism is important for diastolic blood pressure response to benazepril treatment (24). However, we did not find any association between B2AR and the diseases investigated in this study.…”

Section: Modification Of Such Risk Factors To Prevent Cvds Is Well Escontrasting

confidence: 80%

Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area

Wang

Lee

et al. 2007

Clinical Chemical Laboratory Medicine

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Section: Modification Of Such Risk Factors To Prevent Cvds Is Well Escontrasting

confidence: 80%

Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area

Wang

Lee

et al. 2007

Clinical Chemical Laboratory Medicine

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“…Variants of ADRB2 have been associated with asthma exacerbations and salmeterol response 59,60 . However, antihypertensive and cardiac investigations of beta-blockers and ACEIs have yielded mixed results of the ADRB2 variants, rs1042713 and rs1042714, in predicting BP and congestive heart failure responses 10,17,56,57,[61][62][63] . Rs4994, a polymorphism in ADRB3, has been evaluated in hypertensive studies.…”

Section: Candidate Pharmacodynamic Polymorphisms Of Adrenergic Responsementioning

confidence: 99%

A Physiologic Approach to the Pharmacogenomics of Hypertension

Eadon

Chapman

2016

Advances in Chronic Kidney Disease

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“…Indeed, the present study showed that Arg/Arg was associated with an increased risk of IC and also influenced the response to tricyclic antidepressant therapy compared with Arg/Gly or Gly/Gly. It has also been reported that Arg16Gly polymorphism of ADRB2 is associated with a greater decrease of the diastolic blood pressure in response to benazepril treatment (8), while the Gly16 allele of the ADBR2 gene confers resistance to parasitic infections (13). Cellular immunity and humoral immunity usually maintain a balance, but infection sometimes induces allergy or autoimmune disease by upsetting this balance.…”

Section: Polymorphism Of the Adrb2 (Arg16gly) Genementioning

confidence: 99%

Efficacy of tricyclic antidepressant is associated with beta2-adrenoceptor genotype in patients with interstitial cystitis

et al. 2006

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We examined the relationship between the Arg16Gly polymorphism of β2-adrenoceptor (ADRB2) and the efficacy of tricyclic antidepressant therapy in patients with interstitial cystitis (IC). We studied 55 IC patients and 113 controls. The IC patients were treated with imipramine hydrochloride, and the efficacy of treatment was categorized by patients' satisfaction (no change, fair, or good). Genomic DNA was extracted from the controls and IC patients, and the Arg16Gly polymorphism of ADRB2 was analyzed. The Arg16Gly polymorphism showed a significant difference in prevalence between IC patients and controls, and Arg/Arg was associated with increase in the risk of IC than Arg/Gly or Gly/Gly. Regarding the tricyclic antidepressant therapy, there was a significant difference in the prevalence of this polymorphism between IC patients with no change or a fair response to treatment and controls, and Arg/Arg was associated with decrease in the response rate to tricyclic antidepressant therapy than Arg/Gly or Gly/Gly. Therefore, these results suggest that the Arg16Gly polymorphism of ADRB2 is related to down-regulation of ADRB2 expression in the detrusor muscle, so that the response of IC to tricyclic antidepressant therapy depends on the Arg16Gly polymorphism.Interstitial cystitis (IC) is a chronic disorder with symptoms that include urinary urgency, frequency, nocturia, and bladder pain (10, 12). On cystoscopy, petechial hemorrhages and/or Hunner's ulcers are found after distension of the bladder (9). Several possible causative factors have been proposed, but the etiology and pathophysiology of IC are still unknown. Epidemiological studies have shown that patients with IC are 100 times more likely to have inflammatory bowel disease than healthy persons (1). IC is often associated with allergic diseases, and 40 to 80% of these patients have allergies (16). These findings suggest that IC is an immunological disease of the bladder.Regarding the treatment of IC, a randomized trial showed the marked improvement of symptoms after 4 months of tricyclic antidepressant therapy (17). Tricyclic antidepressant blocks the active transport system that is involved in the re-uptake of serotonin and noradrenaline (4). The detrusor muscle of the bladder shows abundant expression of the β2-adrenoceptor (ADRB2), and polymorphisms of the ADRB2 gene have been suggested to show a close association with various allergic diseases. For example, an arginine-to-glycine substitution at codon 16 (Arg16Gly) is related to down-regulation of ADRB2 (6), which is thought to be one of the pathogenic factors in asthma (7). Therefore, the effect of tricyclic antidepressant on CI may be related to polymorphism of the ADRB2 (Arg16Gly) gene and to

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β₂Adrenergic Receptor GeneArg16GlyPolymorphism is Associated with Therapeutic Efficacy of Benazepril on Essential Hypertension in Chinese

Abstract: Our family-based study provided the first evidence that ADRB2 R16G polymorphism may play an important role in DBP response to benazepril treatment, although the magnitude of the effect appears to be modified by other risk factors such as plasma lipid and glucose profiles.

Cited by 7 publications

References 37 publications

Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area

Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area

A Physiologic Approach to the Pharmacogenomics of Hypertension

Efficacy of tricyclic antidepressant is associated with beta2-adrenoceptor genotype in patients with interstitial cystitis

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β2Adrenergic Receptor GeneArg16GlyPolymorphism is Associated with Therapeutic Efficacy of Benazepril on Essential Hypertension in Chinese

Abstract: Our family-based study provided the first evidence that ADRB2 R16G polymorphism may play an important role in DBP response to benazepril treatment, although the magnitude of the effect appears to be modified by other risk factors such as plasma lipid and glucose profiles.

Cited by 7 publications

References 37 publications

Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area

Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area

A Physiologic Approach to the Pharmacogenomics of Hypertension

Efficacy of tricyclic antidepressant is associated with beta2-adrenoceptor genotype in patients with interstitial cystitis

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β₂Adrenergic Receptor GeneArg16GlyPolymorphism is Associated with Therapeutic Efficacy of Benazepril on Essential Hypertension in Chinese