β-TCP/MCPM-based premixed calcium phosphate cements

Han, Bing; Ma, Pengwei; Zhang, Lili; Yin, Yuji; Yao, Kangde; Zhang, Fu-Jiang; Zhang, Yongdong; Li, Xiulan; Nie, Wei

doi:10.1016/j.actbio.2009.04.024

Cited by 67 publications

(74 citation statements)

References 35 publications

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“…However, this was previously shown not be the explanation to the monetite formation in premixed cements since monetite is the predominant phase in pCPC formulations even with an excess of β-TCP [19]. Previous publications on acidic pCPC have reported that the cements form monetite at 37°C [14,19] in accordance with the results in the present study. Although, monetite is the more stable phase in water, the activation energy for nucleation of brushite is lower than for monetite, and brushite is thus initially formed in all cements [37].…”

Section: Citationsupporting

confidence: 82%

“…When mixed with water, the basic CPCs normally precipitate into hydroxyapatite, while acidic CPCs normally form brushite as the set phase [15,16]. However, when the acidic CPCs have been prepared as premixed pastes the resulting phase after setting has been shown to be mainly monetite [14,17,18]. It is argued that the method of premixing the cements will cause a higher acidity locally in the cement, which could explain the formation of monetite instead of brushite [19]; however, this has not to the authors' knowledge been studied explicitly.…”

Section: Introductionmentioning

confidence: 99%

“…PCPCs have been evaluated in vivo showing good biocompatibility [11,12]. This type of premixed calcium phosphate pastes has been made from both basic [13] and acidic [14] calcium phosphate mixtures. When mixed with water, the basic CPCs normally precipitate into hydroxyapatite, while acidic CPCs normally form brushite as the set phase [15,16].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Setting Mechanisms of an Acidic Premixed Calcium Phosphate Cement

Åberg¹,

Unosson

Engqvist³

2013

Bioceram Dev Appl

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Premixed calcium phosphate cements (pCPC), where glycerol is used instead of water as mixing liquid, present better handling characteristics than water-based cements. However, the setting mechanisms of pCPC have not been described thoroughly. The aim of this paper is to increase the understanding of the setting mechanism of pCPC. The investigated cement starts to set when glycerol is exchanged with water via diffusion of glycerol out to the surrounding body fluid and water into the material. To better understand the water-glycerol exchange a method was developed where the setting depth of the cement was measured over time. Thermo gravimetric analysis (TGA) was used to determine the liquid exchange rate during setting. To study the influence of temperature on the crystalline end product, pCPC and water-mixed calcium phosphate cement (wCPC) were set at different temperatures and analyzed with X-ray diffraction (XRD). The setting depth measurements showed that the set layer of the pCPC grew with a speed proportional to t 0.51 at 37°C. TGA results furthermore showed that less than 10% of the glycerol remained after 16 hours. Setting of pCPC at different temperatures showed that mainly brushite was formed at 5°C, a mixture of brushite and monetite at 21°C and mainly monetite at 37°C. It furthermore showed that brushite was the main phase after setting of wCPC, but some monetite was present in these cements. The study presents a new method for evaluation of pCPC that increases the understanding of their setting mechanism. Furthermore, the XRD results indicate that storage at 5°C could improve the shelf life of acidic pCPC.

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Section: Citationsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Setting Mechanisms of an Acidic Premixed Calcium Phosphate Cement

Åberg¹,

Unosson

Engqvist³

2013

Bioceram Dev Appl

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“…To slow down the rate of biodegradation, biphasic calcium phosphate (BCP) ceramics (i.e. composite ceramics that consist of mixtures of both the HA and b-TCP phase) have been proposed [18,19]. HA is the main mineral component of bone and teeth.…”

Section: Tricalcium Phosphate [Ca 3 (Po 4 ) 2 ]mentioning

confidence: 99%

Ion implantation of titanium based biomaterials

Rautray

Narayanan

Kim

2011

Progress in Materials Science

271

136

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“…To overcome these drawbacks several research groups have investigated and evaluated the possibility of using premixed CPCs. [16][17][18] In most premixed CPCs the powders are mixed with a water-miscible non-aqueous liquid, e.g., glycerol 16 or low molecular weight poly(ethylene glycol) (PEG), 17 forming a paste that starts setting in vivo, giving a long working time. The setting of the paste first starts when the paste is injected into the body and the glycerol or PEG is exchanged for body fluids, i.e., water.…”

Section: Introductionmentioning

confidence: 99%