β -Thalassaemia and its Co-existence with Haemoglobin E and Haemoglobin S in Upper Assam Region of North Eastern India: A Hospital Based Study

Teli, Anju Barhai; Deori, Rumi; Saikia, Sidhartha Protim; Pathak, Kalyani; Panyang, Rita; Rajkakati, Rashmi

doi:10.7860/jcdr/2016/16265.7675

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…that may affect Hb status and anemia prevalence ( 28 ). In this study, the low malaria-endemic district i.e., Udalguri had a majority of people belonging to low socioeconomic status, labor class that works in tea estates on daily wages and consume a high quantity of tea that inhibits dietary iron absorption ( 29 ) with a high prevalence of Hb S, E and β-thalassemia disease ( 30 – 32 ). We found that the lowest Hb concentration was present in children below 5 years of age.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of malaria and anemia in high and low malaria-endemic North-Eastern districts of India

Singh

Hussain

Phookan

et al. 2022

Front. Public Health

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Anemia and malaria are the two major public health problems that lead to substantial morbidity and mortality. Malaria infection destroys erythrocytes, resulting in low hemoglobin (Hb) levels known as anemia. Here we report the determinants of anemia in high and low malaria-endemic areas that would help understand which parasite densities, age, and gender-associated low Hb levels. Therefore, a cross-sectional mass survey (n = 8,233) was conducted to screen anemia and malaria in high and low malaria-endemic districts (HMED and LMED) of North-East India. Axillary body temperature was measured using a digital thermometer. The prevalence of anemia was found to be 55.3% (4,547/8,233), of which 45.1% had mild (2,049/4,547), 52.1% moderate (2,367/4,547) and 2.9% had severe anemia (131/4,547). Among anemic, 70.8% (3,219/4,547) resided in LMED and the rest in HMED. The median age of the anemic population was 12 years (IQR: 7–30). Overall, malaria positivity was 8.9% (734/8,233), of which HMED shared 79.6% (584/734) and LMED 20.4% (150/734) malaria burden. The village-wise malaria frequency was concordant to asymptomatic malaria (10–20%), which showed that apparently all of the malaria cases were asymptomatic in HMED. LMED population had significantly lower Hb than HMED [standardized beta (β) = −0.067, p < 0.0001] and low-density Plasmodium infections had higher Hb levels than high-density infections (β = 0.113; p = 0.031). Women of reproductive age had higher odds for malaria (OR: 1.42; 95% CI: 1.00–2.05; p = 0.04). Females (β = −0.193; p < 0.0001) and febrile individuals (β = −0.029; p = 0.008) have shown lower Hb levels, but malaria positivity did not show any effect on Hb. Young children and women of reproductive age are prone to anemia and malaria. Although there was no relation between malaria with the occurrence of anemia, we found low-density Plasmodium infections, female gender, and LMED were potential determinants of Hb.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of malaria and anemia in high and low malaria-endemic North-Eastern districts of India

Singh

Hussain

Phookan

et al. 2022

Front. Public Health

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“…[6,7,8,9]. The present study found 39 cases to have hypophosphatemia which account for 38.61%, which may be due to renal function derangements and abnormality of bone marrow turnover [10,11].…”

Section: Discussionmentioning

confidence: 46%

Clinico-pathological profile of paediatric patients with thalassemia major

Sharma

Tikkas

Uikey

et al. 2020

IJPR

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Background:The average prevalence of beta-thalassemia major is 3-4% which translates to 35-45 million carriers. Repeated use of blood transfusion in these patients causes significant morbidity and associated adverse effects. Aims and Objective: To study the clinical profile and laboratory parameters of Thalassemia major patients between the age group 1-14 years. . This included history, anthropometry, clinical examinations (general and systemic examinations) and laboratory Investigations including serum ferritin. RESULT: result showed that 42% patients were found to be underweight, 26.73% were short stature, 31.68% were hypocalcemic, 44.5% had low serum alkaline phosphatase. Transfusion frequency and serum ferritin were less in 1-5 years. A significant correlation was observed between the size of the spleen and the level of ferritin. CONCLUSION: Hereby it can be concluded that early diagnosis of the disease and early institution of chelation therapy can improve the life expectancy of the Beta-thalassemia patients.So, all these children require regular monitoring of endocrine functions after 5 years of age, and regular monitoring of height, weight semi-annuallyy.

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Prevalence of beta thalassemia carriers in India: a systematic review and meta-analysis

Sumedha,

Anita

2023

J Community Genet

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β -Thalassaemia and its Co-existence with Haemoglobin E and Haemoglobin S in Upper Assam Region of North Eastern India: A Hospital Based Study

Cited by 6 publications

References 13 publications

Epidemiology of malaria and anemia in high and low malaria-endemic North-Eastern districts of India

Epidemiology of malaria and anemia in high and low malaria-endemic North-Eastern districts of India

Clinico-pathological profile of paediatric patients with thalassemia major

Prevalence of beta thalassemia carriers in India: a systematic review and meta-analysis

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