β-tricalcium phosphate for bone substitution: Synthesis and properties

Bohner, Marc; Santoni, Bastien Le Gars; Döbelin, Nicola

doi:10.1016/j.actbio.2020.06.022

Cited by 486 publications

(331 citation statements)

References 324 publications

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“…Calcium phosphates are the most widely-used bioceramics due to their chemical and structural similarities with the mineral part of bones [50]. Among them, hydroxyapatite (HAp, Ca 10 (PO 4 ) 6 (OH) 2 ) and tricalcium phosphate (TCP, Ca 3 (PO 4 ) 2 ) are often studied, alone or mixed together to form Biphasic Calcium Phosphates (BCP) [51][52][53][54]. BCP are interesting materials because of the difference in solubility of the two compounds, which enables the regulation of bioresorbability and the kinetic release of the ionic components [55].…”

Section: Calcium Phosphate Bioceramicsmentioning

confidence: 99%

Biological properties of copper-doped biomaterials for orthopedic applications: A review of antibacterial, angiogenic and osteogenic aspects

et al. 2020

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Copper is an essential trace element required for human life, and is involved in several physiological mechanisms. Today researchers have found and confirmed that Cu has biological properties which are particularly useful for orthopedic biomaterials applications such as implant coatings or biodegradable filler bone substitutes. Indeed, Cu exhibits antibacterial functions, provides angiogenic ability and favors osteogenesis; these represent major key points for ideal biomaterial integration and the healing process that follows. The antibacterial performances of copper-doped biomaterials present an interesting alternative to the massive use of prophylactic antibiotics and help to limit the development of antibiotic resistance. By stimulating blood vessel growth and new bone formation, copper contributes to the improved bio-integration of biomaterials. This review describes the bio-functional advantages offered by Cu and focuses on the antibacterial, angiogenic and osteogenic properties of Cu-doped biomaterials with potential for orthopedic applications.

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Section: Calcium Phosphate Bioceramicsmentioning

confidence: 99%

Biological properties of copper-doped biomaterials for orthopedic applications: A review of antibacterial, angiogenic and osteogenic aspects

et al. 2020

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“…The synthetic materials arouse great interest, because of their reliable and reproducible chemical composition and microscopic architecture [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…The most studied materials for bone reconstruction are calcium phosphate ceramics, as well as hydroxyapatite (HA) and β -tricalcium phosphate ( β -TCP) [ 27 ]. HA is widely considered a useful solution in secondary cranioplasty, providing a stable osteoconductive scaffold for bone regeneration, being resistant to resorption [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Wide Anterior Maxillary Reconstruction with Equine Bone Xenograft: A Case Report of 24-Month Follow-Up

Cicco

Colella

Tartaro

et al. 2020

Case Reports in Surgery

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Introduction. Orofacial reconstruction plays an important role in the treatment of patients affected by oral and maxillofacial cancers. Improvements in technologies and studies of biomaterials have widely expanded surgical possibilities to achieve good functional and aesthetic outcomes. By the way, xenografting procedures gained great consensus in the last decades, because of their documented reliability and efficacy. We present a case of anterior maxillary chondrosarcoma (CHS) that has undergone surgical ablation followed by reconstruction with an equine-derived bone xenograft. Case Presentation. A 68-year-old woman affected by CHS of the premaxilla underwent surgical ablation involving the four incisors followed by reconstruction using an equine-derived bone substitute. Bony reconstruction was planned to achieve implant and dental prosthetic rehabilitation at a second surgical time. Primary surgery was carried out without complications. Good integration of the graft was confirmed by radiological examination. At 12-month follow-up, the patient refused the implant placement and spontaneously adopted a mobile prosthesis. One year later, plates and screws were removed, because of the exposure of a titanium plate. The graft was finally rejected within 3 weeks. Discussion. Nonantigenic equine-derived biomaterials have shown reliability and a good safety profile. In the presented case, implant insertion should have been performed 12 months after the primary surgery. During the follow-up, until dental mobile prosthesis was applied, clinical and instrumental examinations demonstrated a good integration of the graft. We suppose that a chronic inflammation of the mucosa led to the exposure of the plate, perhaps due to pressure, minimal movements, or imperfect fitting of the mobile prosthesis. Removal of fixation means was performed to prevent grafting failure, without success. On the other hand, missing load could induce the graft to act just like a prosthesis, without a real process of integration. Safety and reliability of equine-derived bone xenografts cannot be currently confirmed if not followed by implant insertion and dental rehabilitation.

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“…The first generation of these materials focused on ceramics-based materials, which is represented by hydroxyapatite and other calcium phosphates ( Cutright et al, 1972 ; Yamada et al, 1997 ; LeGeros, 2002 ; Tien et al, 2004 ; Ogose et al, 2005 ; Komaki et al, 2006 ; Ng et al, 2008 ; Fei et al, 2012 ; Wang et al, 2012 ; Liu et al, 2013 ). While these materials have been widely used in clinic and achieved certain successes, their applications in large bone defects are extremely challenging due to their limited bioactivity and flexibility ( Woodard et al, 2007 ; Chocholata et al, 2019 ; Bohner et al, 2020 ). However, ideal bone tissue engineering scaffolds may require sufficient porosity with proper pore size distribution and interconnectivity, capability to facilitate cell-material interactions, as well as potency to actively regulate stem cell behaviors.…”

Section: Introductionmentioning

confidence: 99%

Utility of Air Bladder-Derived Nanostructured ECM for Tissue Regeneration

Wang

Chen²,

Ran³

et al. 2020

Front. Bioeng. Biotechnol.

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Exploration for ideal bone regeneration materials still remains a hot research topic due to the unmet clinical challenge of large bone defect healing. Bone grafting materials have gradually evolved from single component to multiple-component composite, but their functions during bone healing still only regulate one or two biological processes. Therefore, there is an urgent need to develop novel materials with more complex composition, which convey multiple biological functions during bone regeneration. Here, we report an naturally nanostructured ECM based composite scaffold derived from fish air bladder and combined with dicalcium phosphate (DCP) microparticles to form a new type of bone grafting material. The DCP/acellular tissue matrix (DCP/ATM) scaffold demonstrated porous structure with porosity over 65% and great capability of absorbing water and other biologics. In vitro cell culture study showed that DCP/ATM scaffold could better support osteoblast proliferation and differentiation in comparison with DCP/ADC made from acid extracted fish collagen. Moreover, DCP/ATM also demonstrated more potent bone regenerative properties in a rat calvarial defect model, indicating incorporation of ECM based matrix in the scaffolds could better support bone formation. Taken together, this study demonstrates a new avenue toward the development of new type of bone regeneration biomaterial utilizing ECM as its key components.

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β-tricalcium phosphate for bone substitution: Synthesis and properties

Cited by 486 publications

References 324 publications

Biological properties of copper-doped biomaterials for orthopedic applications: A review of antibacterial, angiogenic and osteogenic aspects

Biological properties of copper-doped biomaterials for orthopedic applications: A review of antibacterial, angiogenic and osteogenic aspects

Wide Anterior Maxillary Reconstruction with Equine Bone Xenograft: A Case Report of 24-Month Follow-Up

Utility of Air Bladder-Derived Nanostructured ECM for Tissue Regeneration

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