β-tricalcium phosphate synthesized in organic medium for controlled release drug delivery application in bio-scaffolds

Sahadat Hossain, Md.; Shaikh, Md. Aftab Ali; Uddin, Md. Najem; Bashar, Muhammad Shahriar; Ahmed, Samina

doi:10.1039/d3ra04904c

RSC Adv.

2023

DOI: 10.1039/d3ra04904c

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β-tricalcium phosphate synthesized in organic medium for controlled release drug delivery application in bio-scaffolds

Md. Sahadat Hossain,

Md. Aftab Ali Shaikh,

Md. Najem Uddin

et al.

Abstract: β-tricalcium phosphate (β-TCP) was synthesized in an organic medium (acetone) to obtain a single-phase product while calcium carbonate (CaCO3) and ortho-phosphoric acid (H3PO4) were the sources of Ca, and P, respectively.

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Cited by 4 publications

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Synthesis, Characterization, and Functional Analysis of Mixed Manganese/Cerium Oxide/Hydroxyapatite Nanocomposites for Antibacterial Applications

Siri-Udom,

Prasitnok,

Prasitnok

et al. 2024

J Clust Sci

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Synthesis, Characterization, and Functional Analysis of Mixed Manganese/Cerium Oxide/Hydroxyapatite Nanocomposites for Antibacterial Applications

Siri-Udom,

Prasitnok,

Prasitnok

et al. 2024

J Clust Sci

View full text Add to dashboard Cite

Bioceramic materials in bone-implantable drug delivery systems: A review

Nayak,

Maity,

Barik

et al. 2024

Journal of Drug Delivery Science and Technology

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Synthesis of different types of calcium phosphates for the drug loading and releasing applications

Sahadat Hossain,

Tarannum,

Ullah

et al. 2024

Int J Applied Ceramic Tech

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Abstractβ‐tricalcium phosphate and various forms of hydroxyapatites (HAps) were produced through the wet chemical precipitation method, using calcium hydroxide, orthophosphoric acid, cow bone, and fish scale as raw materials. The synthesized samples underwent characterization through x‐ray diffraction, and their antimicrobial efficacy was assessed in powder form for gram‐positive Staphylococcus aureus bacteria as well as gram‐negative Escherichia coli bacteria. In vitro degradation tests were conducted using simulated body fluid after compressing the powdered samples into scaffolds and sintering at 900°C. These scaffolds were subsequently used to study drug loading and releasing over different periods. All scaffolds demonstrated strong loading capacities for amoxicillin (AMX) and ciprofloxacin (CIP), notably Rui bone HAp achieving 90.83% loading of AMX and cow bone HAp showing 98.73% loading of CIP. In contrast, both fluoride‐doped HAp types displayed significant AMX release, whereas Rui bone HAp showed the highest CIP release. The pH and conductivity of drugs and drug‐released SBF solution were examined after 21 days and 1 day, respectively.

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β-tricalcium phosphate synthesized in organic medium for controlled release drug delivery application in bio-scaffolds

Abstract: β-tricalcium phosphate (β-TCP) was synthesized in an organic medium (acetone) to obtain a single-phase product while calcium carbonate (CaCO3) and ortho-phosphoric acid (H3PO4) were the sources of Ca, and P, respectively.

Cited by 4 publications

References 48 publications

Synthesis, Characterization, and Functional Analysis of Mixed Manganese/Cerium Oxide/Hydroxyapatite Nanocomposites for Antibacterial Applications

Synthesis, Characterization, and Functional Analysis of Mixed Manganese/Cerium Oxide/Hydroxyapatite Nanocomposites for Antibacterial Applications

Bioceramic materials in bone-implantable drug delivery systems: A review

Synthesis of different types of calcium phosphates for the drug loading and releasing applications

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