β2-Adrenoceptor gene polymorphisms and blood pressure variations in East Anglian Caucasians

Jia, Hao; Sharma, Pankaj; Hopper, Ruth; Dickerson, Claire; Lloyd, Deborah D.

doi:10.1097/00004872-200018060-00005

Cited by 46 publications

(14 citation statements)

References 38 publications

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“…Finally, the 164Ile variant of the ADRB2 is associated with a decreased native adipocyte receptor function. 14 Although several previous reports have described associations between these polymorphisms and hypertension or obesity, [15][16][17][18][19][20] few studies have taken into account both variables in the same design. To our knowledge, this is the most extensive work done analyzing these polymorphisms and blood pressure and obesity phenotypes both as continuous and dichotomous variables in the same population.…”

Section: Discussionmentioning

confidence: 99%

“…The relations between the polymorphisms of the ADRB2 gene and hypertension phenotypes have been assessed in European, 18 American, 19 Japanese, 16,17 and African Caribbean 20 populations, and the apparent lack of consistency in the results among these studies may be, at least partially, attributable to ethnic differences. Another possible explanation for the discordant data regarding association of these alleles with hypertension is a population-specific role for a particular allele.…”

Section: Discussionmentioning

confidence: 99%

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β2 Adrenoceptor Functional Gene Variants, Obesity, and Blood Pressure Level Interactions in the General Population

et al. 2003

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Abstract-We investigated the association of ␤2 adrenoceptor functional gene variants (Arg16Gly, Gln27Glu, and Thr164Ile polymorphisms), obesity phenotypes, and blood pressure levels in a large, ethnically mixed urban population. The individuals (nϭ1576) were randomly selected for a cross-sectional study of cardiovascular risk factors in Vitória, Brazil. Statistically significant associations among systolic blood pressure and the Arg16Gly and Thr164Ile variants were identified in univariate analysis. The Gly16/Gly16 genotype was still associated with systolic blood pressure (SBP) in multivariate analysis adjusting for age, gender, ethnicity, total cholesterol, diabetes, and body mass index (BMI) (Pϭ0.01). The Arg16 allele was the only genotypic variable associated with BMI, and, in a dominant model, it remained associated with an increased BMI even after adjustment for age, gender, ethnicity, triglycerides, HDL cholesterol, LDL cholesterol, diabetes, and hypertension status (Pϭ0.02). Although the different polymorphisms did not interact in the determination of SBP, a significant interaction with BMI (Pϭ0.02), not through linkage disequilibrium, was identified between the Gln27Glu and the Thr164Ile variants. Furthermore, a significant interaction among the Arg16Gly polymorphism and BMI (Pϭ0.036) and waist-hip ratio (Pϭ0.003) in determining SBP was disclosed by ANOVA factorial modeling, with SBP used as the dependent variable. An interaction between the Thr164Ile polymorphism and waist-hip ratio was also identified (Pϭ0.018). Finally, multiple logistic regression models showed a 1.48-fold increase in the risk of hypertension in individuals harboring the Gly16/Gly16 genotype and a 1.31-fold (Pϭ0.01) and a 1.49-fold (Pϭ0.003) increased risk of obesity in individuals harboring the Gln27/Gln27 genotype or the presence of the Arg16 allele, respectively. Taken together, these data provide evidence for a strong but complex relation between ␤-adrenoceptor gene variants, hypertension, and obesity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

β2 Adrenoceptor Functional Gene Variants, Obesity, and Blood Pressure Level Interactions in the General Population

et al. 2003

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“…9 On the contrary, recent data have reported a greater BP fall in the R389R b1AR carriers. 13,14 The role of the G-protein a-(GNAS) and b-(GNB3) subunit polymorphisms (T-C, Ile131 GNAS and C825T GNB3 ) has been analyzed in EH [15][16][17] and in the response to bblockers and thiazides, respectively.…”

Section: Introductionmentioning

confidence: 91%

“…b1, b2 and b3 ARs polymorphisms (R389G b1AR , R16G b2AR and W64R b3AR ) have been associated contradictorily with EH, [5][6][7][8][9][10][11][12] and R16G b2AR was found not predictive of the antihypertensive response to b-blockers. 9 On the contrary, recent data have reported a greater BP fall in the R389R b1AR carriers.…”

Section: Introductionmentioning

confidence: 96%

Genetic polymorphisms of the β-adrenergic system: association with essential hypertension and response to β-blockade

et al. 2004

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“…Other studies have been unable to replicate these findings. [12][13][14][15][16][17][18][19][20] Therefore, in spite of the large number of previous reports about the association between these two polymorphisms and hypertension, the conclusion remains unclear. To clarify the effect of A46G and C79G polymorphisms on the risk of hypertension, we conducted a meta-analysis from all eligible case-control studies published to date.…”

Section: Introductionmentioning

confidence: 99%

A46G and C79G polymorphisms in the β2-adrenergic receptor gene (ADRB2) and essential hypertension risk: a meta-analysis

et al. 2010

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No consensus has been reached on the association between the b2-adrenergic receptor polymorphisms A46G and C79G and essential hypertension risk. We performed a meta-analysis to confirm the possible association. After reviewing 303 reports in PubMed and 359 reports in Embase, we included in our meta-analysis 18 articles (20 studies) that met our inclusion criteria. The fixed-effects model and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. There was no statistical association between A46G and hypertension risk in all subjects, Asians or Caucasians. However, an association was observed in the dominant genetic model (AA vs. (AG+GG)) (P¼0.04, odds ratio (OR)¼1.38, 95% confidence interval (CI) 1.01-1.87, P heterogeneity ¼0.98, fixed-effects model) in the subgroup of mixed Africans. No overall statistical association could be found between C79G and hypertension risk or any ethnic subgroup. In the research conducted on severe hypertension (systolic blood pressure X160 mm Hg and/or diastolic blood pressure X95 mm Hg hypertensive population), significant association was found in the dominant genetic model (CC vs. (CG+GG)) (P¼0.04, OR¼1.38, 95% CI 1.02-1.86, P heterogeneity ¼0.03, random-effects model), and there was also a borderline significance between the C79 allele and severe hypertension (P¼0.05, OR¼1.26, 95% CI 1.00-1.57, P heterogeneity ¼0.04, random-effects model). No association could be found in this study between the two polymorphisms and stage 2 hypertension. More studies stratified for different ethnicities and different stages of hypertension should be performed in the future.

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β2-Adrenoceptor gene polymorphisms and blood pressure variations in East Anglian Caucasians

Abstract: These findings suggest that the amino-terminal polymorphisms of the beta2AR gene are unlikely to constitute major susceptibility for essential hypertension in the East Anglian population.

Cited by 46 publications

References 38 publications

β2 Adrenoceptor Functional Gene Variants, Obesity, and Blood Pressure Level Interactions in the General Population

β2 Adrenoceptor Functional Gene Variants, Obesity, and Blood Pressure Level Interactions in the General Population

Genetic polymorphisms of the β-adrenergic system: association with essential hypertension and response to β-blockade

A46G and C79G polymorphisms in the β2-adrenergic receptor gene (ADRB2) and essential hypertension risk: a meta-analysis

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