β2‐Glycoprotein I‐Dependent Anti‐Cardiolipin Antibodies Associated With Periodontitis in Patients With Systemic Lupus Erythematosus

Wang, Chen-Ying; Chyuan, I‐Tsu; Wang, Yali; Kuo, Mark Yen‐Ping; Chang, Chiung‐Fang; Wu, King‐Jean; Hsu, Ping–I; Nagasawa, Toshiyuki; Wara-aswapati, Nawarat; Chen, Yiwen

doi:10.1902/jop.2015.140664

Cited by 23 publications

(35 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A review by Karnoutsos et al summarizes evidence that a peptide found i n β 2 G P I m a y a l s o b e f o u n d i n A c t i o b a c i l l u s actinomycetemcomitans and P. gingivalis [93]. Wang et al [94] reported that aPL were associated with periodontitis in patients with SLE and confirmed the presence of P. gingivalis and Treponema denticola in saliva and plaque samples of these patients, detected by PCR.…”

Section: Periodontal Infections Smoking and Aplmentioning

confidence: 99%

Anti-phospholipid Antibodies and Smoking: An Overview

Binder

Litwin

2016

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

Antiphospholipid syndrome is characterized by the presence of antiphospholipid antibodies, specifically lupus anticoagulant, anticardiolipin antibodies, and anti-β2 glycoprotein-I antibodies. Antiphospholipid syndrome can occur on its own or in association with other autoimmune diseases, most commonly systemic lupus erythematosus (SLE). A connection between cigarette smoking and anti-phospholipid antibodies (aPL) was first reported in the late1980s. Systemic lupus erythematosus patients with aPL are more likely to be smokers than those without aPL. These patients have a particularly high frequency of vascular events. Recently, a potential link between periodontitis, tobacco, and aPL has been proposed. Research has also suggested that periodontitis and Porphyromonas gingivalis infection are associated with citrullination through the action of peptidylarginine deiminase. A strong correlation between smoking and the presence of citrillunated autoantibodies, which are characteristic of rheumatoid arthritis, has also been observed. While many studies have investigated possible links between infection and aPL in patients with autoimmune diseases, the association of smoking with aPL has not been systematically examined. The fact that both aPL and tobacco are risk factors for thrombosis has complicated efforts to evaluate these factors separately. Also, there has been great variability in measurement techniques, and laboratories lack routine methods for differentiating transient and persistent aPL; both of these factors can make interpretation of autoantibody results quite challenging. This review summarizes the clinical evidence supporting a posited link between aPL and smoking, both in patients with a systemic autoimmune disease and in patients with other medical conditions.

show abstract

Section: Periodontal Infections Smoking and Aplmentioning

confidence: 99%

Anti-phospholipid Antibodies and Smoking: An Overview

Binder

Litwin

2016

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

show abstract

“…An environmental factor that modulates autoimmunity is the bidirectional crosstalk between the human host and microbiota, as reported for rheumatic diseases [18, 19]. However, few studies have addressed the relationship between SLE and the human microbiota [20, 21] or the periodontal condition in SLE patients [10, 16, 22–27]. Moreover, the results have been conflicting, due in part to small sample size.…”

Section: Introductionmentioning

confidence: 99%

Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status

et al. 2017

View full text Add to dashboard Cite

BackgroundPeriodontitis results from the interaction between a subgingival biofilm and host immune response. Changes in biofilm composition are thought to disrupt homeostasis between the host and subgingival bacteria resulting in periodontal damage. Chronic systemic inflammatory disorders have been shown to affect the subgingival microbiota and clinical periodontal status. However, this relationship has not been examined in subjects with systemic lupus erythematosus (SLE). The objective of our study was to investigate the influence of SLE on the subgingival microbiota and its connection with periodontal disease and SLE activity.MethodsWe evaluated 52 patients with SLE compared to 52 subjects without SLE (control group). Subjects were classified as without periodontitis and with periodontitis. Oral microbiota composition was assessed by amplifying the V4 region of 16S rRNA gene from subgingival dental plaque DNA extracts. These amplicons were examined by Illumina MiSeq sequencing.ResultsSLE patients exhibited higher prevalence of periodontitis which occurred at a younger age compared to subjects of the control group. More severe forms of periodontitis were found in SLE subjects that had higher bacterial loads and decreased microbial diversity. Bacterial species frequently detected in periodontal disease were observed in higher proportions in SLE patients, even in periodontal healthy sites such as Fretibacterium, Prevotella nigrescens, and Selenomonas. Changes in the oral microbiota were linked to increased local inflammation, as demonstrated by higher concentrations of IL-6, IL-17, and IL-33 in SLE patients with periodontitis.ConclusionsSLE is associated with differences in the composition of the microbiota, independently of periodontal status.Electronic supplementary materialThe online version of this article (doi:10.1186/s40168-017-0252-z) contains supplementary material, which is available to authorized users.

show abstract

“…Diferenças intra-grupo (na coluna) significantes na prevalência de Aa em comparação a espécies dos complexos amarelo, verde, laranja e vermelho; Diferenças intra-grupo (na coluna) significantes na prevalência de outras espécies em comparação aos complexos amarelo, verde e laranja; Diferenças intra-grupo (na coluna) significantes na prevalência de bactérias do complexo verde em comparação ao laranja Poucos estudos avaliaram uma possível associação entre LES e doença periodontal (WANG et al 2015;MUTLU et al, 1993;MEYER et al, 2000;NOVO et al 1999;RHODUS et al 1990;NOVO et al 1999;KOBAYASHI et al 2003;KOBAYASHI et al 2007;FABBRI et al 2014) , 2001;STAPLES et al, 1974;CHEN et al, 2004). A escolha pela análise exclusivamente de mulheres baseou-se em sua maior prevalência de LES quando comparado a homens, além das diferenças de manifestação da doença, sendo comumente mais graves em homens (TAN et al, 2012).…”

Section: Les-i [Média(95%ciunclassified

“…Apenas um estudo (WANG et al, 2015) É importante mencionar que a diferença dos resultados encontrados em relação a outras pesquisas pode ser também explicada por diferentes critérios de definição de doença periodontal encontrados na literatura (RHODUS et al 1990;NOVO et al 1999;KOBAYASHI et al 2003;KOBAYASHI et al 2007;FABBRI et al 2014). Nesse trabalho, foi utilizado protocolo de exame periodontal de boca toda, conforme sugerido por Eke et al ANNANE et al, 2004;STAPLES et al, 1974;CHEN et al, 2004;PRYOR;BOLOGNA;KAHL, 1996).…”

Section: Les-i [Média(95%ciunclassified

“…Nesse trabalho, foi utilizado protocolo de exame periodontal de boca toda, conforme sugerido por Eke et al ANNANE et al, 2004;STAPLES et al, 1974;CHEN et al, 2004;PRYOR;BOLOGNA;KAHL, 1996). Há maior susceptibilidade de pacientes imunossuprimidos a infecções (STAPLES et al, 1974;CHEN et al, 2004;PRYOR;BOLOGNA;KAHL, 1996) (WANG et al 2015;MUTLU et al 1993;MEYER et al 2000;NOVO et al 1999 STEFFENS et al, 2010;PAJU;SCANNAPIECO, 2007;FISHER et al, 2008;BAHEKAR, 2007).…”

Section: Les-i [Média(95%ciunclassified

See 1 more Smart Citation

Efeito de inibidores da atividade proteolítica na resistência de união de pino de fibra de vidro à dentina radicular após 12 meses

Chaves¹

View full text Add to dashboard Cite

show abstract

β2‐Glycoprotein I‐Dependent Anti‐Cardiolipin Antibodies Associated With Periodontitis in Patients With Systemic Lupus Erythematosus

Abstract: Elevated anti-CL and anti-β2GPI antibody levels were associated with periodontopathic bacteria and periodontal breakdown in patients with SLE. Periodontitis might be a modifiable risk factor for SLE.

Cited by 23 publications

References 47 publications

Anti-phospholipid Antibodies and Smoking: An Overview

Anti-phospholipid Antibodies and Smoking: An Overview

Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status

Efeito de inibidores da atividade proteolítica na resistência de união de pino de fibra de vidro à dentina radicular após 12 meses

Contact Info

Product

Resources

About