β2-microglobulin is overexpressed in buccal cells of elderly and correlated with expression of p16 and inflammatory genes

Althubiti, Mohammad

doi:10.1016/j.sjbs.2022.103418

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…CroR@aB2MG targets senescent cells effectively, with the direction of an anti-B2MG antibody. The expression of blood-borne B2MG, a biomarker for cancer and many inflammatory diseases [ 47 - 49 ] has been found positively correlated with age, the levels of p16 ink4a , IL-1β and IL-6, and the oxidative stress [ 50 , 51 ]. This is in line with our results, as CroR@aB2MG-mediated NIR irradiation reduced DOX-boosted senescence marked by the enhanced expression of p16 ink4a , p53, DcR2, FOXO4 and the loss of lamin B1.…”

Section: Discussionmentioning

confidence: 99%

An Antibody-directed and Immune Response Modifier-augmented Photothermal Therapy Strategy Relieves Aging via Rapid Immune Clearance of Senescent Cells

Han,

Zheng,

et al. 2024

Aging and disease

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Cellular senescence is an irreversible and multifaceted process inducing tissue dysfunction and organismal aging, and thus the clearance of senescent cells can prevent or delay the onset of aging-related pathologies. Herein, we developed an augmented photothermal therapy strategy integrated with an antibody against β2-microglobulin (aB2MG) and an immune adjuvant imiquimod (R837) to effectively accelerate senescent cell apoptosis and clearance under a near-infrared light. With this strategy, the designed CroR@aB2MG enables the targeting of senescent cells and the application of photothermal therapy concomitantly, the initiation of immune clearance subsequently, and finally the realization of protective effects against senescence. Our results showed that the photo-induced heating effect caused senescent cells to quickly undergo apoptosis and the synchronous immune response accelerated the clearance of senescent cells in vitro and in vivo . Therefore, this photoactivated speedy clearing strategy may provide an efficient way for the treatment of senescence-related diseases by eliminating senescent cells with biomaterials.

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