ββ-Dichloro-α-aminoacrylonitrile

A challenging synthesis of new 1,3,4‐thiadiazole derivatives starting from 2‐acylamino‐3,3‐dichloroacrylonitriles

“…Starting from these reagents, the preparative syntheses were elaborated for a number of functional derivatives c 2004 Wiley Periodicals, Inc. of 1,3-oxazole [1][2][3][4][5][6][7]10,11], 4H-imidazole [8], and 1,3,4-oxadiazole [9]. The present work addresses a new line in harnessing of 2-acylamino-3,3-dichloroacrylonitriles for the preparation of interesting 1,3,4-thiadiazole derivatives.…”

“…It is more than 30 years since two research teams, in Japan and Ukraine, started systematic studies on the conversions of 2-acylamino-3,3-dichloroacrylonitriles demonstrating unique properties as reagents for heterocyclizations [1][2][3][4][5][6][7][8][9][10][11]. Starting from these reagents, the preparative syntheses were elaborated for a number of functional derivatives c 2004 Wiley Periodicals, Inc. of 1,3-oxazole [1][2][3][4][5][6][7]10,11], 4H-imidazole [8], and 1,3,4-oxadiazole [9].…”

Synthesis of new heterocyclic system of 4,5,7,8‐tetrahydroimidazo[1,2‐c][1,3]thiazolo [4,5‐e][1,3,2]diazaphosphinine starting from 2‐aroylamino‐3,3‐dichloroacrylonitrile

“…2-Aroylamino-3,3-dichloroacrylonitriles that are readily prepared from easily accessible chloral adducts of carboxamides [1][2][3][4] have been extensively utilized in heterocyclic synthesis [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The present study offers their new application as starting materials to obtain a hitherto unknown heterocyclic system, 4,5,7,8-tetrahydroimidazo [1,2c] [1,3]thiazolo [4,5-e] [1,3,2]diazaphosphinine.…”

“…The present study offers their new application as starting materials to obtain a hitherto unknown heterocyclic system, 4,5,7,8-tetrahydroimidazo [1,2c] [1,3]thiazolo [4,5-e] [1,3,2]diazaphosphinine.…”

N-methyl-D-glucamine-derived 4-substituted 1,3-oxazoles

“…In the 70s of the last century Drach et al [16] and Matsumura et al [17] found that the interaction of available 1-acylamino-2,2-dichloroacrylonitriles I with primary or secondary amines afforded substituted 5-amino-1,3-oxazole-4-carbonitriles in high yields [16,17]. Later the reaction was used for the preparation of 5-amino-1,3-oxazoles containing ester [18], phosphonyl [19], sulfonyl [20], and other group in the position 4.…”