γ-carboxyglutamic acid in urine of newborn infants

Sann, L; Leclercq, M; Fouillit, M.; Chapuis, M; Bruyère, André

doi:10.1016/0009-8981(84)90098-6

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…As is shown in Table 2, the inter-individual variation of the Gla/creat ratio is smaller in young adults than in children or newborns, which may reflect a more stabilized Gla protein metabolism in the adult group. These observations lead to the conclusion that Gla excretion in newborns is at least similar to that in adults, which is consistent with the finding that total Gla excretion per 24 hours and per body weight does not depend on age (Sann et al 1984).…”

Section: Discussionsupporting

confidence: 78%

Apolipoprotein E genotype may influence urinary gammacarboxyglutamate (Gla) concentrations in young individuals

Crăciun¹,

Vermeer²

2014

gpb

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Abstract. Upon degradation of vitamin K-dependent proteins (known as Gla-proteins) the free aminoacid Gla cannot be re-utilized and is excreted in the urine, where it can be used as an overall marker for vitamin K status. We report the urinary Gla excretion values in first morning void urine for healthy young Romanian subjects from birth, childhood and young adulthood. In these subjects we have evaluated age, gender and apo E genotype as potential confounders. The urinary free Gla/ creat ratio (Gla/creat, mg/g) was highest in newborns (34.8 ± 19.5; p < 0.001), than fell in the group 4 to 48 months old (13.1 ± 11.1) to levels that were not significantly different from the young adult group (18.3 ± 5.5). No gender-related differences were observed in Gla/creat in newborns and young children, but Gla excretion in women was higher than in men (28.6%; p < 0.029). Remarkably, Gla excretion in subjects bearing the apo ε 2 + allele was significantly lower (11.9 ± 4.2) than in those bearing combinations of the ε 3 + and ε 4 + alleles (20.3 ± 4.1). The novelty of this study resides in the evaluation of urinary Gla excretion in relation with apo E genotype, suggesting that apo ε2 allele is a risk factor for developing vitamin K insufficiency.

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Section: Discussionsupporting

confidence: 78%