γ-Fe₂O₃/CNTs Composites for Electrochemical Detection of Paracetamol: Synthesis, Phase Transition and Enhanced Properties

Abstract

In this work, γ-Fe2O3/CNTs composite was facile synthesized by simple hydrothermal method and hydrazine hydrate treatment at low temperature (CNTs = carbon nanotubes). The result of VSM shows that the saturation magnetization of Fe2O3/CNTs composites increase from 0 to 1.29 emu g−1 after hydrazine hydrate treatment, indicating that the Fe2O3 in the composite transforms from α phase to γ phase. Moreover, the electrochemical properties of both α-Fe2O3/CNTs and γ-Fe2O3/CNTs was studied. Compared with α-Fe2O3/CNTs, γ-Fe2O3/CNTs shows enhanced electrochemical performance toward paracetamol determination. Under optimum condition, the γ-Fe2O3/CNTs modified electrode exhibits two linear ranges of 2.5 μM−385 μM and 593 μM−1550 μM and a low detection limit of 0.046 μM. In addition, the constructed sensor can be successfully utilized for detecting paracetamol in different water bodies. This work provides a new clue for the design and construction of excellent electrochemical sensor for paracetamol determination.

Synergistic effect of gold nanoparticles anchored on conductive carbon black as an efficient electrochemical sensor for sensitive detection of anti-COVID-19 drug Favipiravir in absence and presence of co-administered drug Paracetamol

“… Analyte Electrode LDR / μM LOD / nM Ref. FVP CPT-BDD/GCE 0.064 – 130 18.0 [10] MnO 2 -rGO SPE 0.01 – 55 9.0 [11] DNPs/CPE 0.02 – 1.0 4.83 [12] GC/MWCNTs + ILCs 0.9 – 150 16.0 [13] Pt@rGO/GCE 3.16 – 100 2460 [14] PCT AuNPs/ MWCNT/GCE 0.09 – 35 30 [39] PEDOT/GO/GCE 10 – 60 570 [40] Pt/NDG 0.05 – 90 8.0 [41] GCE/Pd-SB 1.0 – 50 67 [42] γ-Fe 2 O 3 /CNTs 2.5 − 385 46 [43] ZnO/FMWCNT/CPE 0.5 – 13 23 [44] FVP Au@CCB/GNFPE 0.03 – 77.3 8.1 This work FVP and PCT Au@CCB/GNFPE FVP: 0.03 – 75PCT: 0.05 – 50 7.54.3 Note: LOD (limit of detection) LDR (linear dynamic range), GCE (glassy carbon electrode), PEDOT (poly(3, 4-ethylenedioxythiophene), GO (graphene oxide), Pt (platinum), NDG (nitrogen doped graphene), Pd-SB (Pd-Schiff base), CPT-BDD GCE (cathodically pretreated boron-doped diamond glassy carbon electrodes), MnO 2 -rGO SPE (MnO 2 -reduced graphene oxide screen-printing electrodes), DNPs/CPE (diamond nanoparticles/carbon paste electrode), GC/MWCNTs+ILCs (glassy carbon / carbon nanotubes-ioni...…”

“…The sensitivity of the sensing electrode toward the determination of PCT and FVP was observed to be 11.8 and 6.8 μ A μ M -1 cm -2 , respectively. The performance of the Au@CCB/GNFPE sensor in comparison with other published platforms for the detection of PCT [39] , [40] , [41] , [42] , [43] , [44] and FVP is shown in Table 3 . The proposed sensor exhibited a broad linear range and lower detection limits for both the antiviral drug FVP and the co-administered drug PCT when compared with previously reported values.…”

Surface engineering of carbon microspheres with nanoceria wrapped on MWCNTs: a dual electrocatalyst for simultaneous monitoring of molnupiravir and paracetamol

“…Many methods are described in the literature that can measure MPV or PCM using HPLC, [12][13][14] UV spectrophotometry, 15,16 and electrochemical methods. [17][18][19][20][21][22][23][24][25][26][27][28] However, except for electrochemical methods, all other analytical methods are complicated, tedious, timeconsuming, and expensive. Electrochemical methods are timesaving, simple, real-time, user-friendly, and economically worthwhile.…”

Electrochemical Determination of 17-β-Estradiol Using a Glassy Carbon Electrode Modified with α-Fe2O3 Nanoparticles Supported on Carbon Nanotubes

“…In the literature, there are examples of the use of the α-Fe 2 O 3 and CNT composites in the modification of electrodes. They have been primarily used for the electroanalytical determination of drugs [41][42][43].…”