γ-Fe2O3 nanoparticles embedded in nanohydroxyapatite matrix for magnetic hyperthermia and in vitro osteoblast cell studies

Ramos-Guivar, Juan A.; Morales, Marco A.; Litterst, F. J.

doi:10.1016/j.ceramint.2020.01.072

Cited by 26 publications

(15 citation statements)

References 38 publications

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“…There have been many studies reporting the acceptable biocompatibility of Fe 3 O 4 and Fe 2 O 3 particles in micro-to nano size ranges towards various cell lines including osteoblast cells. [98][99][100] Ramos-Guvar et al demonstrated that γ-Fe 2 O 3 nanoparticles (NPs) did not harm the viability of the Saos-2 cells even at high concentration and promisingly, the NPs escalated the cells proliferation and adhesion up to 24-h exposition time. [98] Very recently, Marycz et al have shown that Fe 2 O 3 nanoparticles incited osteoblasts differentiation and impeded osteoclasts activity.…”

Section: The In Vitro Biocompatibility Of Fe-based Oxide Productsmentioning

confidence: 99%

“…[98][99][100] Ramos-Guvar et al demonstrated that γ-Fe 2 O 3 nanoparticles (NPs) did not harm the viability of the Saos-2 cells even at high concentration and promisingly, the NPs escalated the cells proliferation and adhesion up to 24-h exposition time. [98] Very recently, Marycz et al have shown that Fe 2 O 3 nanoparticles incited osteoblasts differentiation and impeded osteoclasts activity. Based on all of the findings, they suggested that the nanoparticles were completely biocompatible.…”

Section: The In Vitro Biocompatibility Of Fe-based Oxide Productsmentioning

confidence: 99%

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Insight into the bioabsorption of Fe‐based materials and their current developments in bone applications

Yusop

Ulum

Sakkaf

et al. 2021

Biotechnology Journal

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Iron (Fe) and Fe-based materials have been vigorously explored in orthopedic applications in the past decade mainly owing to their promising mechanical properties including high yield strength, elastic modulus and ductility. Nevertheless, their corrosion products and low corrosion kinetics are the major concerns that need to be improved further despite their appealing mechanical strengths. The current studies on porous Fe-based scaffolds show an improved corrosion rate but the in vitro biocompatibility is still problematic in general. Unlike the Mg implants, the biodegradation and bioabsorption of Fe-based implants are still not well described. This vague issue could implicate the development of Fe-based materials as potential medical implants as they have not reached the clinical trial stage yet. Thus, there is a need to understand in-depth the Fe corrosion behavior and its bioabsorption mechanism to facilitate the material design of Fe-based scaffolds and further improve its biocompatibility. This manuscript provides an important insight into the basic bioabsorption of the multi-ranged Fe-based corrosion products with a review of the latest progress on the corrosion & in vitro biocompatibility of porous Fe-based scaffolds together with the remaining challenges and the perspective on the future direction.

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Section: The In Vitro Biocompatibility Of Fe-based Oxide Productsmentioning

confidence: 99%

Section: The In Vitro Biocompatibility Of Fe-based Oxide Productsmentioning

confidence: 99%

Insight into the bioabsorption of Fe‐based materials and their current developments in bone applications

Yusop

Ulum

Sakkaf

et al. 2021

Biotechnology Journal

View full text Add to dashboard Cite

show abstract

“…Results were promising and showed that the addition of maghemite to HAp does not induce any cytotoxicity in the final NPs, even when 125 μg ml −1 of the NPs was incubated with the cells for 24 h. In this article, it was also reported that the NPs showed small coercive fields in the M-H loops, and after functionalizing the NPs, H c still showed the same value (H c = 70 Oe). 146 Moreover, the values of saturation magnetization (M s ) for GFeHAp were around 12 emu g −1 , which was less than the M s of the bare maghemite NPs and revealed that the synthesized NPs were not superparamagnetic. This was suggested to happen because of the size of NPs, which was above 10 nm.…”

Section: Crystalline Bioceramics For Magnetic Htmentioning

confidence: 98%

“…In a recent study, maghemite (γ-Fe 2 O 3 ) NPs were synthesized and embedded in a nanohydroxyapatite (HAp) matrix (GFeHAp) using the coprecipitation method. 146 An experiment under AC magnetic fields was carried out to study the heat-generating properties of the final particles. The results showed that, when the concentration of NPs in water reached 20 mg ml −1 , the temperature increased to 45°C during 10 min.…”

Section: Crystalline Bioceramics For Magnetic Htmentioning

confidence: 99%

A critical review of bioceramics for magnetic hyperthermia

et al. 2021

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Hyperthermia (HT) is a rapid cancer therapy inducing cellular apoptosis by increasing the local temperature of cancerous tissues between 40 and 44°C. 1 The tumors are highly susceptible to this thermal range at which cancerous cells are destroyed, while the normal cells undergo no significant damaging effects. HT is induced by using magnetic materials under an alternating magnetic field (AMF). Benefitting from some favorable characteristics of magnetic nanomaterials (MNPs), magnetic HT has drawn enormous attention and reduced the adverse side effects related to conventional treatments of several tumors such as prostate, glioblastoma, and metastatic bone cancer. 1 This method is usually combined with other therapeutic approaches like chemotherapy (drug delivery), photothermal therapy, gene therapy, immunotherapy, and high-intensity focused ultrasound, which is critically discussed in this paper. 1 The exact process of HT is not yet fully understood since a variety of biological effects can simultaneously occur like heat-induced alteration of cells signaling pathways, DNA, and RNA alterations; expressions of heat-shock proteins; and many other biochemical changes, as well as the direct cytotoxic effect of heat. 2,3 Still, there is a theory which has been mostly accepted by scientists that the impaired vascularization of tumors, together with heat, leads to the lack of oxygen in the tumor environment. As a result, malignant cells escalate their anaerobic metabolism

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“…The application of AEMF was used for increasing the temperature in physiological medium by means of the phenomenon known as hyperthermia [ 106 ]: the γ-Fe 2 O 3 MNPs were embedded in an n-HA matrix and the temperature increased up to 45 °C in 10 min (in the case of scaffolds with saturation magnetization of 12 emu·g −1 ). In this case, besides the positive effect on the bio-activity and mechanical benefits, an anti-cancer therapeutic application of the magneto-responsive scaffold can be proposed.…”

Section: Magneto-responsive Scaffolds For Hard Tissue Regenerationmentioning

confidence: 99%

Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

et al. 2020

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The burst of research papers focused on the tissue engineering and regeneration recorded in the last years is justified by the increased skills in the synthesis of nanostructures able to confer peculiar biological and mechanical features to the matrix where they are dispersed. Inorganic, organic and hybrid nanostructures are proposed in the literature depending on the characteristic that has to be tuned and on the effect that has to be induced. In the field of the inorganic nanoparticles used for decorating the bio-scaffolds, the most recent contributions about the paramagnetic and superparamagnetic nanoparticles use was evaluated in the present contribution. The intrinsic properties of the paramagnetic nanoparticles, the possibility to be triggered by the simple application of an external magnetic field, their biocompatibility and the easiness of the synthetic procedures for obtaining them proposed these nanostructures as ideal candidates for positively enhancing the tissue regeneration. Herein, we divided the discussion into two macro-topics: the use of magnetic nanoparticles in scaffolds used for hard tissue engineering for soft tissue regeneration.

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γ-Fe2O3 nanoparticles embedded in nanohydroxyapatite matrix for magnetic hyperthermia and in vitro osteoblast cell studies

Cited by 26 publications

References 38 publications

Insight into the bioabsorption of Fe‐based materials and their current developments in bone applications

Insight into the bioabsorption of Fe‐based materials and their current developments in bone applications

A critical review of bioceramics for magnetic hyperthermia

Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

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