γ‐Herpesviruses and cellular signaling in AIDS‐associated malignancies

Noguchi, Kohji; Fukazawa, Hidesuke; Murakami, Yuko; Takahashi, Naoko; Yamagoe, Satoshi; Uehara, Yoshimasa

doi:10.1111/j.1349-7006.2007.00555.x

Cited by 11 publications

(11 citation statements)

References 102 publications

(130 reference statements)

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“…Once adopted, the nonproductive latency program is characterized by constitutive expression of a small subset of KSHV genes, many of which are localized to a single locus [ 2 , 4 , 10 ]. The program is well documented to occur in both virus-harboring KS spindle cells and PEL cells [ 2 , 3 , 4 , 10 , 11 , 12 , 13 , 14 ].…”

Section: Kaposi’s Sarcoma-associated Herpesvirus Latency and Reactmentioning

confidence: 99%

KSHV Reactivation and Novel Implications of Protein Isomerization on Lytic Switch Control

Guito

Lukac

2015

Viruses

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In Kaposi’s sarcoma-associated herpesvirus (KSHV) oncogenesis, both latency and reactivation are hypothesized to potentiate tumor growth. The KSHV Rta protein is the lytic switch for reactivation. Rta transactivates essential genes via interactions with cofactors such as the cellular RBP-Jk and Oct-1 proteins, and the viral Mta protein. Given that robust viral reactivation would facilitate antiviral responses and culminate in host cell lysis, regulation of Rta’s expression and function is a major determinant of the latent-lytic balance and the fate of infected cells. Our lab recently showed that Rta transactivation requires the cellular peptidyl-prolyl cis/trans isomerase Pin1. Our data suggest that proline‑directed phosphorylation regulates Rta by licensing binding to Pin1. Despite Pin1’s ability to stimulate Rta transactivation, unchecked Pin1 activity inhibited virus production. Dysregulation of Pin1 is implicated in human cancers, and KSHV is the latest virus known to co-opt Pin1 function. We propose that Pin1 is a molecular timer that can regulate the balance between viral lytic gene expression and host cell lysis. Intriguing scenarios for Pin1’s underlying activities, and the potential broader significance for isomerization of Rta and reactivation, are highlighted.

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Section: Kaposi’s Sarcoma-associated Herpesvirus Latency and Reactmentioning

confidence: 99%

KSHV Reactivation and Novel Implications of Protein Isomerization on Lytic Switch Control

Guito

Lukac

2015

Viruses

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“…11 In addition, intracellular Notch1 is elevated in latent phase of HHV-8 in primary effusion lymphoma cell lines, 5 and the increased intracellular Notch1 is potentially able to reactivate HHV-8 from its latency by binding to DNA-binding protein recombination signal sequence-binding protein-J kappa to convert this complex to a positive transcriptional complex from a corepressor complex. 12 In fact, the crystal structure of C promoter binding factor clearly shows that intracellular Notch1 binds the hydrophobic pocket on C promoter binding factor. 13 The expression of Notch1 in primary effusion lymphoma patients may also shed light on the potential therapeutic use of Notch1 inhibitors on primary effusion lymphoma patients.…”

Section: Discussionmentioning

confidence: 99%

Notch1 in primary effusion lymphoma: a clinicopathological study

Wang¹,

Fuda²,

Chen³

et al. 2010

Modern Pathology

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“…Further, Furler and Uittenbogaart (2010) argue that cytokine and biomarker expression in HIV-1 infection results from the combined effect of intracellular signaling pathways orchestrated by kinases like p38 and ERK, and that p38, ERK and Mitogen-Activated Protein Kinase (MAPK) pathways govern the regulation of cytokines (IL-2, IL-10, and TNF-α) as well as biomarkers (PD-1, Fas/FasL, among others) that are skewed in chronic HIV infection. Additionally, HIV utilizes the p38 and ERK pathways to produce new virions to deplete Noguchi et al (2007) showed that EBER can activate NF-kB and IRF3 pathways. EBER-mediated signaling has been associated with cytokine expressions in EBV-infected cells.…”

Section: Discussionmentioning

confidence: 99%

Cytokine and Chemokine Expression Profiles in HIV-1 Infected Patients with Ocular Surface Squamous Neoplasia from Botswana

Simbiri¹,

Jha²,

Dzeng³

et al. 2012

CCO

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Purpose: Ocular surface squamous neoplasia (OSSN) rate has increased in incidence with the HIV pandemic in Africa. Multiple factors including cellular and environmental can affect the pathogenesis of OSSN in HIV-infected patients. We will investigate anti-inflammatory cytokines, proinflammatory cytokines, and growth factor expression in sera and tissue samples of OSSN and pterygia for the potential link to the development of OSSN. Results: Antibody analysis showed significant changes in levels of pro-inflammatory cytokines, anti-inflammatory cytokines and growth factors in sera. Quantitative RT-PCR of tissues showed expression of inflammatory cytokines and chemokines associated with HIV infection and carcinogenesis. Conclusion: Our findings showed that dysregulation in expression of cytokines and growth factors in patients with multiple infections may contribute to pathogenesis of OSSN and pterygia. The data reinforces the significance of in depth analysis of immune function in HIV-1 OSSN patients with multiple viral infections that has potential for therapy and vaccine development.

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γ‐Herpesviruses and cellular signaling in AIDS‐associated malignancies

Cited by 11 publications

References 102 publications

KSHV Reactivation and Novel Implications of Protein Isomerization on Lytic Switch Control

KSHV Reactivation and Novel Implications of Protein Isomerization on Lytic Switch Control

Notch1 in primary effusion lymphoma: a clinicopathological study

Cytokine and Chemokine Expression Profiles in HIV-1 Infected Patients with Ocular Surface Squamous Neoplasia from Botswana

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