γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction

Wang, Anqi; Li, Dan; Wang, Shengpeng; Zhou, Fayang; Wang, Ying; Lin, Ligen

doi:10.1016/j.jff.2017.11.047

Cited by 19 publications

(14 citation statements)

References 48 publications

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“…Additionally, γ-mangostin also increased the expression of silent mating type information regulation 2 homologs 1 (SIRT1) which is important for maintaining cellular oxidative stress, in particular reducing ROS production from mitochondrial activity. The action of γ-mangostin in regulating both NRF2 and SIRT1 has been shown in both human hepatocyte cell line L02 induced by oxidants (tert-butyl hydroperoxide) as well as in mice treated with carbon tetrachloride toxic drug (Wang et al, 2018a), suggesting the applicability of this compound in ameliorating liver toxification and oxidative damage.…”

Section: Introductionmentioning

confidence: 99%

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Aizat¹,

Jamil²,

Ahmad-Hashim³

et al. 2019

PeerJ

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Background Mangosteen (Garcinia mangostana L.) fruit has a unique sweet-sour taste and rich in beneficial compounds such as xanthones. Mangosteen has been originally used in various folk medicines to treat diarrhea, wound, and fever. More recently, it has been used as a major component in health supplement products for weight loss and promoting general health. This is perhaps due to its known medicinal benefits including as anti-oxidant and anti-inflammation. Interestingly, the publications related to mangosteen has surged in recent years suggesting its popularity and usefulness in research laboratories. However, there is still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method In this review, we have covered recent articles within the year of 2016 to 2018, which focuses on several aspects including the latest findings on compound composition from mangosteen fruit as well as its medicinal usages. Result Mangosteen has been vastly used in medicinal areas including as anti-cancer, anti-microbial, and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel, and cardiovascular tissues against disorders and diseases. Conclusion All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study; drug development and human applications.

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Section: Introductionmentioning

confidence: 99%

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Aizat¹,

Jamil²,

Ahmad-Hashim³

et al. 2019

PeerJ

View full text Add to dashboard Cite

show abstract

“…The compound also protects those cells from oxidative damage by H 2 O 2 , perhaps by increasing anti-oxidant enzymes such as superoxide dismutase (SOD) and glutathione as well as reducing the level of active Caspase-3 important for apoptosis (Liu et al 2018). Wang et al (2018a) further showed that another major compound from mangosteen, γmangostin also exhibited hepatoprotective ability. The compound induced the expression of nuclear factor erythroid 2-related factor 2 (NRF2) which is known to regulate many anti-oxidative enzymes such as heme oxygenase-1 and SOD2.…”

Section: Various Organ Protectionmentioning

confidence: 94%

Peer Review #2 of "Recent updates on metabolite composition and medicinal benefits of mangosteen plant (v0.2)"

2019

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Background. Mangosteen (Garcinia mangostana L.) fruit has unique sweet-sour taste and rich in beneficial compounds such as xanthones. Mangosteen has been originally used in various folk medicines to treat diarrhea, wound and fever. More recently, it has been used as a major component in health supplement products for weight loss and promoting general health. This is perhaps due to its known medicinal benefits including as anti-oxidant and anti-inflammation. Interestingly, the publications related to mangosteen has surged in recent years suggesting its popularity and usefulness in research laboratories. However, there is still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method. In this review, we have covered recent articles within the year of 2016 to 2018, which focuses on several aspects including the latest findings on compound composition from mangosteen fruit as well as its medicinal usages. Result. Mangosteen has been vastly used in medicinal area including as anti-cancer, anti-microbial and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel and cardiovascular tissues against disorders and diseases. Conclusion. All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study; drug development and human applications.

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“…In acute liver injury, the administration of ɣ-mangostin showed an increase in SOD and GSH antioxidant levels. It also showed an improved liver condition through increasing nuclear factor erythroid 2-related factor-2 (NRF2) and sirtuin 1 (SIRT1) level (Wang et al, 2018). Meanwhile, the administration of AM increased GSH antioxidant level and inhibited inflammation, apoptosis, and autophagy (Yan et al, 2018).…”

Section: Mangosteen Antioxidant Activity Toward Liver and Kidneymentioning

confidence: 98%

“…A total of four studies tested the mangosteen antioxidant activity toward liver in the acute liver injury model (Wang et al, 2018;Yan et al, 2018), chronic liver injury model (Wang et al, 2019), and hepatic steatosis model (Tsai et al, 2016). The acute and chronic liver injury could occur when the liver is exposed to chemical stresses, such as alcohol and drug consumption, and the difference between the two is the duration of stress exposure (Wang et al, 2018). In acute liver injury, the liver is exposed to the stress in a shorter duration compared to chronic injury.…”

Section: Mangosteen Antioxidant Activity Toward Liver and Kidneymentioning

confidence: 99%

Evaluation of mangosteen (Garcinia mangostana) antioxidant activity in clinical trials and in vivo animal studies: A systematic review

Beatrice¹,

Hartrianti²

2020

J Appl Pharm Sci

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γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction

Cited by 19 publications

References 48 publications

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Peer Review #2 of "Recent updates on metabolite composition and medicinal benefits of mangosteen plant (v0.2)"

Evaluation of mangosteen (Garcinia mangostana) antioxidant activity in clinical trials and in vivo animal studies: A systematic review

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