Δ133p53 and Δ160p53 isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation
Liuqun Zhao,
Tanel Punga,
Suparna Sanyal
Abstract:p53 is a tumor suppressor protein with multiple isoforms that have shared or specific functions. However, two of its isoforms, Δ133p53 and Δ160p53, with large N-terminal deletions, can aggressively cause cancer. These isoforms exert a dominant negative effect on full-length p53 (FLp53), although the precise molecular mechanisms are unknown. Here, we investigated the mechanisms of action of Δ133p53 and Δ160p53 isoforms using chromatin immunoprecipitation, luciferase expression, subcellular fractionation, and im… Show more
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