ΔNp63 overexpression promotes oral cancer cell migration through hyperactivated Activin A signaling

Mundhe, Dhanashree; Mishra, Rupa; Basu, Srikanta; Dalal, Sorab; Kumar, Sanjeev; Teni, Tanuja

doi:10.1016/j.yexcr.2023.113739

Experimental Cell Research

2023

DOI: 10.1016/j.yexcr.2023.113739

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ΔNp63 overexpression promotes oral cancer cell migration through hyperactivated Activin A signaling

Dhanashree Mundhe,

Rupa Mishra,

Srikanta Basu

et al.

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2024

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Cited by 2 publications

References 58 publications

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Dual role of the ∆Np63-miR-141-3p-YAP1 axis in regulating proliferation, migration, and EMT in different cervical carcinoma cell lines

Panahi-Moghadam,

Sadeghizadeh,

Farivar

et al. 2024

Preprint

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Cervical cancer (CC) represents a substantial public health burden, requiring the development of inventive therapeutic approaches. This study explored the functional relationship between the p63 isoform (ΔNp63) and miR-141-3p in modulating migration, invasion, and epithelial–mesenchymal transition (EMT) in two CC cell lines, CaSki, which are human cervical squamous carcinoma cells, and HeLa, which are human cervical adenocarcinoma cells. Our findings revealed dual functions of the ΔNp63-miR-141-3p-YAP1 axis, demonstrating its prometastatic role in HeLa cells through the upregulation of YAP1 and the promotion of proliferation, migration, invasion, and EMT. Conversely, the same axis demonstrated an antimetastatic function in CaSki cells by downregulating YAP1. Notably, YAP1 expression is significantly greater in ADC than in SCC, highlighting its contribution to the aggressive nature of ADC. These data indicate that targeting the ΔNp63-miR-141-3p-YAP1 axis can offer subtype-specific therapeutic options for managing CC.

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Dual role of the ∆Np63-miR-141-3p-YAP1 axis in regulating proliferation, migration, and EMT in different cervical carcinoma cell lines

Panahi-Moghadam,

Sadeghizadeh,

Farivar

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Dual roles of the ∆Np63-miR-141-3p-YAP1 axis in regulating proliferation, migration, and EMT in different cervical carcinoma cell lines

Panahi-Moghadam,

Sadeghizadeh,

Farivar

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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ΔNp63 overexpression promotes oral cancer cell migration through hyperactivated Activin A signaling

Cited by 2 publications

References 58 publications

Dual role of the ∆Np63-miR-141-3p-YAP1 axis in regulating proliferation, migration, and EMT in different cervical carcinoma cell lines

Dual role of the ∆Np63-miR-141-3p-YAP1 axis in regulating proliferation, migration, and EMT in different cervical carcinoma cell lines

Dual roles of the ∆Np63-miR-141-3p-YAP1 axis in regulating proliferation, migration, and EMT in different cervical carcinoma cell lines

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