ε-MnO2-modified graphite electrode as a novel electrochemical sensor for the ultrasensitive detection of the newly FDA approved Hepatitis C antiviral drug ledipasvir

Abdel‐aal, Fatma A. M.; Rageh, Azza H.; Said, Mohamed I.; Saleh, Gamal A.

doi:10.1016/j.aca.2018.07.018

Cited by 31 publications

(15 citation statements)

References 20 publications

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“…The obtained results showed that the formed flakes of X.O. facilitates the charge transfer between the modified electrode surface and oxidized/reduced forms of K 3 [Fe(CN) 6 ] due to the increase in the oxidation/reduction kinetics and larger electroactive surface area of X.O./PGE if compared to bare PGE .…”

Section: Resultsmentioning

confidence: 99%

“…It involves first the removal of one electron from the nitrogen atom of the amidic linkage with the formation of a radical cation . Then in the presence of a water molecule, cleavage of the amidic bond occurs, which involves the loss of methyl carbamate moiety as shown in Scheme . In the presented oxidation scheme the oxidation and cleavage occurs only at one amidic group due to structure bulkiness and the orientation of molecule with respect to the surface of the electrode.…”

Section: Resultsmentioning

confidence: 99%

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Pencil Graphite Electrode Decorated with Xylenol Orange Flakes for Studying Possible Pharmacokinetic Interaction Between Vardenafil and Daclatasvir

et al. 2019

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The main aim of the current work is to investigate possible pharmacokinetic interactions between vardenafil hydrochloride (VAR), which is used for the treatment of erectile dysfunction and daclatasvir dihydrochloride (DAC), which is used for the treatment of chronic hepatitis C viral infection when they are concomitantly administered. Therefore, a sensitive and selective square‐wave voltammetric method was developed and validated for simultaneous determination of VAR and DAC using disposable pencil graphite electrode (PGE) modified with xylenol orange (X.O.) flakes as an electrochemical sensor. A full investigation of the experimental parameters for obtaining the highest electroanalytical signal with sufficient resolution between the oxidation peaks of two compounds was performed. It was found that VAR and DAC were resolved on X.O./PGE with different potentials at 1.4 V and 0.9 V, respectively using Britton‐Robinson buffer (pH 2.2) and 0.1 mol L−1 KCl as a supporting electrolyte. In addition, with the aid of cyclic voltammetry, a mechanistic scheme for the oxidation behaviour of both VAR and DAC was suggested. The proposed square wave voltammetric method was successfully applied for trace quantification of VAR and DAC in male rabbits. The suggested approach shows detection and quantification limits in rabbit plasma samples of 0.06 and 0.17 μmol L−1, respectively for VAR and 0.13 and 0.39 μmol L−1, respectively for DAC. The pharmacokinetic parameters of VAR alone and in combination with DAC after oral administration to rabbits were successfully estimated. The obtained results confirm that when DAC is co‐administered with VAR, plasma concentration of VAR increases, which necessitates dose adjustment for VAR to prevent toxicological consequences in patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Pencil Graphite Electrode Decorated with Xylenol Orange Flakes for Studying Possible Pharmacokinetic Interaction Between Vardenafil and Daclatasvir

et al. 2019

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“…In order to ensure a reproducible electroactive surface area, the same length of the pencil lead is always left outside the support and introduced in the voltametric solution. Electrical contact with the instrument is realized by means of a conductive wire which was soldered or wrapped to the metallic part of the mechanical pencil holder [9,19,21,22,[24][25][26][27][28][29][30][31][32][33][34][35][36][37] (Figure 1a). A micropipette tip [38], an insuline syringe [39], a glass cappilary [40,41], or a plastic [16,[42][43][44][45][46] (Figure 1b) or Teflon tube [47][48][49][50][51][52] (Figure 1c,d) can also act as holder.…”

Section: Pge Manufacturing Proceduresmentioning

confidence: 99%

“…Drop coating was applied to produce Mo 5 O 8 /PGE [34], Trypan blue-modified PGEs [44], different CNT-modified PGEs [47,57,58,68], or PGEs covered with various modifiers [41,49,62,65,135]. After that, the modified PGE was dried either in air [35,48,52,66,68,69,90,136] or in other well-established conditions (e.g., in a desiccator [50] or at a certain temperature [125,137]). The substrate could be either inactivated or electrochemically treated (ET) PGEs (Table 3).…”

Section: Applications Of (Electro)chemically Modified Pges To the Vol...mentioning

confidence: 99%

Recent Developments in Voltammetric Analysis of Pharmaceuticals Using Disposable Pencil Graphite Electrodes

et al. 2022

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The even growing production of both well-known and new derivatives with pharmaceutical action involves the need for developing facile and reliable methods for the analysis of these compounds. Among the widely used instrumental techniques, the electrochemical ones are probably the simplest and the most rapid, also having good performance characteristics. However, the key tool in electroanalysis is the working electrode. Due to the inherent electrochemical and economic advantages of the pencil graphite electrode (PGE), the interest in its applicability in the analysis of different analytes has continuously increased in recent years. Thus, this paper aims to review the scientific reports published in the last 10 years on the use of the disposable eco- and user-friendly PGEs in the electroanalysis of compounds of pharmaceutical importance in different matrices. The PGE characteristics and designs (bare or modified with various types of materials), along with their applications and performance parameters (e.g., linear range, limit of detection, and reproducibility), will be discussed, and their advantages and limitations will be critically emphasized.

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“…36,37 Activated charcoal (ACH) possess also matchless properties with respect to its nontoxic nature, low cost, commercial-availability from extensive natural sources, broad distribution in pore size, electrical conductivity compared with other competitive adsorbents (e.g., CNTs, zeolite and even graphene). 9,[38][39][40][41][42][43][44] These properties make ACH more benefit adsorbing and electro-sensing agent for wide using in various applications. 45 Here, we first demonstrated the in situ preparation of reduced graphene oxide based silver nanoparticles-containing composite (Ag@rGO) with the aid of an in situ reduction way.…”

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confidence: 99%

Ternary Nanocomposite of Activated Charcoal/Reduced Graphene Oxide-Silver Nanoparticles [ACH/Ag@rGO] as a Novel Platform for the First Sensitive Prucalopride Drug Detection in Generic and Innovator Tablets and Human Plasma

Momtaz,

El-Desoky,

Abdel-Galeil

2023

J. Electrochem. Soc.

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Ag@rGO nanocomposite was prepared using an in situ reduction of silver ions and the as-synthesized graphite oxide (GO). Transmission electron microscopy analysis reveals a crumpled- and folded-layered structure of rGO with homogeneously dispersed spherical Ag NPs on these rGO nanosheets. The intensity ratio of the D to G bands (ID/IG) in Raman spectra for Ag@rGO indicates a large defect due to Ag NPs intercalation and deposition on rGO surface. X-ray diffraction indicates the face-centered cubic crystal structure of Ag with average crystalline size of 19.63 nm. An electrochemical sensor based on Ag@rGO is first designed for Prucalopride drug oxidation and characterized applying electrochemical impedance spectroscopy and cyclic voltammetry. Its electrocatalytic effect was enhanced upon utilizing a characterized activated charcoal (ACH) as an electro-modified carbon nanomaterial for CPE. The ternary nanocomposite [ACH/Ag@rGO] as a platform of CPE supposed three times higher response to Prucalopride compared to CPE. Prucalopride was quantified over wide linear ranges of (5.0×10-9–1×10-6 M) and (2.0×10-8–1.4×10-6 M), with LOD values of 7.95×10-10 M and 8.51×10-9 M in bulk form and spiked human plasma, respectively. This sensor can thus be adopted easily for quality control analysis of Prucalopride in formulation and human plasma and for pharmacokinetic study.

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ε-MnO2-modified graphite electrode as a novel electrochemical sensor for the ultrasensitive detection of the newly FDA approved Hepatitis C antiviral drug ledipasvir

Cited by 31 publications

References 20 publications

Pencil Graphite Electrode Decorated with Xylenol Orange Flakes for Studying Possible Pharmacokinetic Interaction Between Vardenafil and Daclatasvir

Pencil Graphite Electrode Decorated with Xylenol Orange Flakes for Studying Possible Pharmacokinetic Interaction Between Vardenafil and Daclatasvir

Recent Developments in Voltammetric Analysis of Pharmaceuticals Using Disposable Pencil Graphite Electrodes

Ternary Nanocomposite of Activated Charcoal/Reduced Graphene Oxide-Silver Nanoparticles [ACH/Ag@rGO] as a Novel Platform for the First Sensitive Prucalopride Drug Detection in Generic and Innovator Tablets and Human Plasma

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