Εxtragenital Adenomatoid tumour of the omentum: An unusual location

Skafida, E; Tsavari, Aikaterini; Koulia, K; Myoteri, Despoina; Grammatoglou, Xanthippi; Zisi, Anna; Varras, M; Vasilakaki, Thivi

doi:10.13172/2052-0077-2-1-364

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“…12 To date, there have been <20 adenomatoid tumours involving the gastrointestinal tract reported in the literature, including one in the pancreas, six involving omentum or mesentery with variable intestinal wall involvement, five involving the liver and one within the appendix (Table 3). 7,12,[22][23][24][25][26][27][28][29][30][31][32] However, the true incidence of adenomatoid tumours involving the gastrointestinal tract is difficult to ascertain, as many of these lesions may have been misclassified on final diagnosis, possibly as other benign entities or mesothelial lesions not further subclassified. While most were reportedly single lesions, three of these cases harboured multiple tumours, including one patient with nodules involving both the liver and peritoneum and another patient with multiple tumours in the mesocolon and omentum.…”

Section: Discussionmentioning

confidence: 99%

Adenomatoid tumours of the gastrointestinal tract – a case‐series and review of the literature

et al. 2021

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Adenomatoid tumours of the gastrointestinal tracta case-series and review of the literature Aims: Adenomatoid tumours are mesothelial-derived benign neoplasms with a predilection for the genital tract. Extragenital sites are rare and can cause significant diagnostic challenges. Herein, we describe the clinicopathological features of a cohort of adenomatoid tumours involving the gastrointestinal tract and liver in order to more clearly characterise their histological findings and aid in diagnosis. Methods and results:The pathology databases at four institutions were searched for adenomatoid tumours involving the gastrointestinal tract or liver, yielding eight cases. Available clinicoradiological and followup data were collected from the medical records. Six tumours were incidentally discovered during imaging studies or at the time of surgical exploration for unrelated conditions; presenting symptoms were unknown in two patients. Histologically, the tumours were well-circumscribed, although focal illdefined borders were present in four cases. No infiltration of adjacent structures was identified.Architectural heterogeneity was noted in five (63%) tumours; an adenoid pattern often predominated. The neoplastic cells were flattened to cuboidal with eosinophilic cytoplasm. Cytoplasmic vacuoles mimicking signet ring-like cells were present in five (63%) cases. Three (38%) cases showed involvement of the mesothelium with reactive mesothelial hyperplasia. Cytological atypia or increased mitotic activity was not identified. The surrounding stroma ranged from oedematous/myxoid to densely hyalinised. Immunohistochemistry confirmed mesothelial origin in all cases evaluated. No patients developed recurrence of disease. Conclusions: The current study evaluates the clinicopathological findings in a collective series of gastrointestinal and hepatic adenomatoid tumours, correlating with those described in individually reported cases. We highlight common histological features and emphasise variable findings that could mimic a malignant neoplasm.

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