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            π‐Olefin Complexes by β‐Hydride Elimination

Hutton, Alan T.

doi:10.1002/9780470145272.ch5

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…A world figure in science long before joining UCT at the age of 71, he continued to exert a profound influence throughout and beyond his tenure of posts in the School (Irving et al, 1978;Irving, 1980Irving, , 1982Irving & Hutton, 1982;Williams & Gillard, 1987;Irving, 1994;Irving & Hutton, 1994). The eulogy delivered by an ex-student, a close colleague of Irving and staff member of the Department of Analytical Science, A.T. Hutton Hutton, 1990), brilliantly encapsulated the qualities of this exceptionally talented man (Hutton, 1994). Irving was succeeded by a former UCT student, Associate Professor Michael J. Orren, who was active in research before leaving after a few years to take up the headship of Oceanography at the university in Galway, Ireland (Orren & Monteiro, 1985;Orren & Pougnet, 1986).…”

Section: School Of Chemical Sciences 1974-1988mentioning

confidence: 98%

A history of the Chemistry Department, University of Cape Town

Stephen¹

2005

Transactions of the Royal Society of South Africa

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includes material from its inception in 1876 until the closing years of the millennium preceding 1999. Several phases of growth are presented: first, as a one-man enterprise, Professor Paul Daniel Hahn introduced the teaching of Chemistry and fostered both pure and applied research; this developed with the founding of the University of Cape Town at the end of World War 1. A move into the new building at Groote Schuur followed, with a rapid expansion on many fronts after World War II. Apart from a brief interlude as a School comprising four separate Departments (1974)(1975)(1976)(1977)(1978)(1979)(1980)(1981)(1982)(1983)(1984)(1985)(1986)(1987)(1988), the Department of Chemistry continued to grow in terms of student numbers, courses offered, and productivity of its research groups, until the present time. The Department has occupied a large building, named after its first full-time professor, since 1972. Advances in performance, consequent on improved, computerised instrumentation and teaching techniques, are evident.

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Section: School Of Chemical Sciences 1974-1988mentioning

confidence: 98%

A history of the Chemistry Department, University of Cape Town

Stephen¹

2005

Transactions of the Royal Society of South Africa

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Alkylgold(III) Complexes Undergo Unprecedented Photo‐Induced β‐Hydride Elimination and Reduction for Targeted Cancer Therapy

et al. 2022

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Spatiotemporally controllable activation of prodrugs within tumors is highly desirable for cancer therapy to minimize toxic side effects. Herein we report that stable alkylgold(III) complexes can undergo unprecedented photo‐induced β‐hydride elimination, releasing alkyl ligands and forming gold(III)‐hydride intermediates that could be quickly converted into bioactive [AuIII−S] adducts; meanwhile, the remaining alkylgold(III) complexes can photo‐catalytically reduce [AuIII−S] into more bioactive AuI species. Such photo‐reactivities make it possible to functionalize gold complexes on the auxiliary alkyl ligands without attenuating the metal–biomacromolecule interactions. As a result, the gold(III) complexes containing glucose‐functionalized alkyl ligands displayed efficient and tumor‐selective uptake; notably, after one‐ or two‐photon activation, the complexes exhibited high thioredoxin reductase (TrxR) inhibition, potent cytotoxicity, and strong antiangiogenesis and antitumor activities in vivo.

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Alkylgold(III) Complexes Undergo Unprecedented Photo‐Induced β‐Hydride Elimination and Reduction for Targeted Cancer Therapy

et al. 2022

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Spatiotemporally controllable activation of prodrugs within tumors is highly desirable for cancer therapy to minimize toxic side effects. Herein we report that stable alkylgold(III) complexes can undergo unprecedented photo-induced β-hydride elimination, releasing alkyl ligands and forming gold(III)-hydride intermediates that could be quickly converted into bioactive [Au III À S] adducts; meanwhile, the remaining alkylgold(III) complexes can photo-catalytically reduce [Au III À S] into more bioactive Au I species. Such photoreactivities make it possible to functionalize gold complexes on the auxiliary alkyl ligands without attenuating the metal-biomacromolecule interactions. As a result, the gold(III) complexes containing glucose-functionalized alkyl ligands displayed efficient and tumor-selective uptake; notably, after one-or two-photon activation, the complexes exhibited high thioredoxin reductase (TrxR) inhibition, potent cytotoxicity, and strong antiangiogenesis and antitumor activities in vivo.

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η ² π‐Olefin Complexes by β‐Hydride Elimination

Cited by 3 publications

References 46 publications

A history of the Chemistry Department, University of Cape Town

A history of the Chemistry Department, University of Cape Town

Alkylgold(III) Complexes Undergo Unprecedented Photo‐Induced β‐Hydride Elimination and Reduction for Targeted Cancer Therapy

Alkylgold(III) Complexes Undergo Unprecedented Photo‐Induced β‐Hydride Elimination and Reduction for Targeted Cancer Therapy

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η 2 π‐Olefin Complexes by β‐Hydride Elimination

Cited by 3 publications

References 46 publications

A history of the Chemistry Department, University of Cape Town

A history of the Chemistry Department, University of Cape Town

Alkylgold(III) Complexes Undergo Unprecedented Photo‐Induced β‐Hydride Elimination and Reduction for Targeted Cancer Therapy

Alkylgold(III) Complexes Undergo Unprecedented Photo‐Induced β‐Hydride Elimination and Reduction for Targeted Cancer Therapy

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η ² π‐Olefin Complexes by β‐Hydride Elimination