Ο Μεταβολισμός Των Λιπιδίων Κατά Την Άσκηση Με Αντιστάσεις

Abstract

Chatzinikolaou Athanasios: Lipids metabolism during resistance exercise (Under the supervision of Professor Taxildaris Kiriakos)Resistance exercise is recommended for the treatment of obesity and diabetes. Its effect on triacylglycerol lipase activity in adipose tissue is not known. The aim of the present study was to investigate the effect of resistance exercise (RE) on lipid metabolism in lean and obese humans. Nine lean and 8 obese healthy men performed a 30-min circuit RE protocol (3 cycles of 10 exercises at 70-75% maximal strength). At baseline, 5 minutes, end of 1st, 2nd and 3rd cycle we sampled adipose tissue for triacylglycerol lipase assay; and blood for norepinephrine, epinephrine, insulin, glucagon, cortisol, non-esterified fatty acid (NEFA), glycerol, glucose and lactate determination. Respiratory gases were monitored throughout exercise. The analysis of data indicated that relative energy expenditure was higher in the lean (2.9 ± 0.5 vs. 2.6 ± 0.8 kcal kg-1, P < 0.05). Respiratory exchange ratio during exercise was higher in the obese (0.98-1.03 vs. 0.92-0.97), suggesting lower fat oxidation.Triacylglycerol lipase activity increased 18-fold at 5 min in the lean and 16-fold at approximately 10 min in the obese; thereafter it declined without reaching baseline. The delay in lipolytic activation in the obese was reflected in the NEFA and glycerol concentrations. Plasma catecholamines increased throughout exercise with no differences between groups. Plasma insulin increased in the obese but did not change in the lean.These findings show that RE upregulated adipose tissue lipolysis and enhanced energy expenditure in lean and obese men. Lipolytic activation in the obese displayed a delay which may be due to the hyperinsulinemic response and may be accountable for the lower fat utilization.