Τriglycerides-glucose (TyG) index is a sensitive marker of insulin resistance in Greek children and adolescents

Dikaiakou, Eirini; Vlachopapadopoulou, Elpis; Paschou, Stavroula Α.; Athanasouli, Fani; Panagiotopoulos, Ιoannis; Kafetzi, Maria; Fotinou, Aspasia; Michalacos, Stefanos

doi:10.1007/s12020-020-02374-6

Cited by 48 publications

(40 citation statements)

References 25 publications

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“…The triglycerideglucose (TyG) index is a compound index that combines fasting blood glucose (FPG) and fasting triglyceride (TG) and can better reflect IR. Because of its convenient acquisition and simple calculation, it has been widely accepted and used clinically [10][11][12]. In a recent study, Er et al found that the combination of the body mass index (BMI) and TyG index can simultaneously reflect the information of many important clinical indexes, such as blood glucose, blood lipids and the BMI, and can better reflect IR than the TyG index alone [13].…”

Section: Introductionmentioning

confidence: 99%

Usefulness of the triglyceride glucose-body mass index in evaluating nonalcoholic fatty liver disease: insights from a general population

et al. 2021

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Background Triglyceride glucose-body mass index (TyG-BMI) is a recently developed alternative indicator to identify insulin resistance. However, few studies have investigated the association between the TyG-BMI and nonalcoholic fatty liver disease (NAFLD). Therefore, this study aimed to study the relationship between NAFLD and the TyG-BMI in the general population and its predictive value. Methods A cross-sectional study was conducted on 14,251 general subjects who took part in a comprehensive health examination. The anthropological characteristics and many risk factors for NAFLD were measured. Results After fully adjusting for confounding variables, a stable positive correlation was found between NAFLD and the TyG-BMI (OR: 3.90 per SD increase; 95% CI: 3.54 to 4.29; P-trend< 0.00001). This positive correlation was not simply linear but a stable non-linear correlation. Additionally, obvious threshold effects and saturation effects were found, in which a threshold effect occurred when the TyG-BMI was between 100 and 150; when the TyG-BMI was between 300 and 400, the corresponding NAFLD risk appeared saturated. Furthermore, receiver operating characteristic analysis showed that the TyG-BMI could better predict the risk of NAFLD than other traditional indicators [TyG-BMI (AUC): 0.886; 95% CI: 0.8797–0.8927; P < 0.0001], particularly among young and middle-aged and non-obese people. Conclusions This epidemiological study is the first on the association between the TyG-BMI and NAFLD risk in the general population. In this large data set from the general population, the TyG-BMI showed an independent positive correlation with NAFLD. The discovery of the threshold effect and saturation effect between them provides a new idea to prevent and treat NAFLD.

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Section: Introductionmentioning

confidence: 99%

Usefulness of the triglyceride glucose-body mass index in evaluating nonalcoholic fatty liver disease: insights from a general population

et al. 2021

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“…decision. [17][18][19] Different from HOMA-IR, the TyG index was universally adaptable in all patients due to the calculation without quantification of insulin. 20,21 It was well distinguished that an increased TyG index would contributing to diagnosing T2DM and predicting related adverse outcomes.…”

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confidence: 99%

Triglyceride–Glucose Index as a Novel Biomarker in the Occurrence of Kidney Stones: A Cross-Sectional Population-Based Study

Jiang¹,

Li²,

Liu³

et al. 2021

IJGM

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Background Triglyceride–glucose (TyG) index has been considered as the reliable marker of insulin resistance (IR), which is one risk factor of kidney stone. This study aimed to evaluate the TyG index in the occurrence of kidney stones among the United States (US) population. Methods Participants who received assessment were retrieved from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018. The logistic regression analysis was conducted to assess the relationship between the TyG index and kidney stones occurrence. A 1:1 matched-pair analysis was established to optimize the bias in kidney stones by propensity score matching (PSM). The dose–response curve was performed to verify the association between the TyG index and risk of kidney stones. Results Of the 14,158 eligible enrolled participants, 1346 (9.5%) self-reported a history of kidney stones. All participants were divided into two groups (high TyG index group and low TyG index group) based on the median TyG index. The dose–response curve exhibited a positive non-linear correlation between the TyG index and kidney stones risk. High TyG index was related to increased kidney stones occurrence in participants, with adjusted odds ratios (AOR) of 1.14 (95% confidence intervals (CI): 1.01–1.30, P = 0.038) compared with the low TyG index subgroup before PSM. After PSM, the risk of kidney stones was 19% higher in the high TyG group compared with the low TyG group (AOR = 1.19, 95% CI: 1.02–1.38, P = 0.026), and the dose–response curve still showed a positive association between TyG index and kidney stone risk. Conclusion The TyG index was independently associated with kidney stones and would be a novel biomarker in predicting occurrence for clinical decision.

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“…The TyG index was rst studied as a marker of identifying insulin resistance (IR) with a high sensitivity and speci city [4,20,21], which has been proposed as an important cause of cardiovascular disease (CVD) [22]. It was demonstrated that the TyG index was a useful predictor of T2DM, as well as CVD [19,23,24].…”

Section: Discussionmentioning

confidence: 99%

The Triglyceride-Glucose Index Is Associated With Atherosclerosis in Patients With Symptomatic Coronary Artery Disease

Hou¹,

Dong²,

Wu³

et al. 2021

Preprint

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Background The triglyceride-glucose index (TyG index) has been suggested as a credible surrogate marker of insulin resistance (IR) for many years. Its value in predicting and diagnosing cardiovascular disease has been reported recently. However, few studies have reported that it can be used as a marker for atherosclerosis and coronary artery disease (CAD), which is one of the main causes of cardiovascular-related death. This study will attempt to prove that the TyG index can be a useful marker for predicting atherosclerosis and has diagnostic significance for symptomatic CAD. Methods The baseline data of 3059 cardiology patients, as well as their clinical data, biochemical parameters and medical histories, were collected from our clinical cases over the last three years. Further screening resulted in 1581 data points of symptomatic CAD. The TyG index was calculated by the formula Ln (fasting triglycerides (mg/dl) × fasting blood glucose (mg/dl)/2). CAD was defined as a nonzero Gensini score on coronary angiography. Participants were divided into four groups according to TyG index tertiles. Results We evaluated 1581 patients, and the majority were male (41.9%) and elderly (59.5%). Cardiometabolic risk factors were positively associated with the TyG index. Arterial damage, including carotid and coronary damage, was highly associated with the TyG index. After adjustment for sex, age and multiple risk factors, Poisson regression analysis indicated that the prevalence ratios for carotid plaque and coronary stenosis were 1.11 (95% Cl 0.55–2.11; P = 0.01) and 2.94 (95% Cl 0.58–1.50; P = 0.01), respectively. Moreover, the TyG index has better diagnostic efficacy for symptomatic CAD than do fasting glucose and triglycerides (AUC TyG = 0.734; AUC fasting glucose = 0.611; AUC triglyceride = 0.717). Conclusion The TyG index is a useful marker for predicting atherosclerosis and may be a diagnostic indicator for symptomatic CAD.

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Τriglycerides-glucose (TyG) index is a sensitive marker of insulin resistance in Greek children and adolescents

Cited by 48 publications

References 25 publications

Usefulness of the triglyceride glucose-body mass index in evaluating nonalcoholic fatty liver disease: insights from a general population

Usefulness of the triglyceride glucose-body mass index in evaluating nonalcoholic fatty liver disease: insights from a general population

Triglyceride–Glucose Index as a Novel Biomarker in the Occurrence of Kidney Stones: A Cross-Sectional Population-Based Study

The Triglyceride-Glucose Index Is Associated With Atherosclerosis in Patients With Symptomatic Coronary Artery Disease

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