χ-Separation Imaging for Diagnosis of Multiple Sclerosis                     versus Neuromyelitis Optica Spectrum Disorder

Kim, Woojun; Shin, Hyeong-Geol; Lee, Hyebin; Park, Dohoon; Kang, Junghwa; Nam, Yoonho; Lee, Jong-Ho; Jang, Jinhee

doi:10.1148/radiol.220941

Cited by 21 publications

(12 citation statements)

References 35 publications

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“…In addition, comparison with QSM approaches for dealing with a large dynamic range of susceptibilities, including the STAR-QSM [68] and TFI [69] methods could not be performed. Furthermore, the present study does not incorporate magnetic source separation to disentangle contributions of para-and diamagnetic sources potentially co-existing within the cysts [70][71][72]. Inclusion of other clinical data such eGFR, ht-TKV and Mayo class [73] into the analysis is necessary to further elucidate the relation between the presence of QSM cyst subclasses and renal function decline.…”

Section: Discussionmentioning

confidence: 99%

Quantitative susceptibility mapping for detection of kidney stones, hemorrhage differentiation and cyst classification in ADPKD

Schumacher,

Prince,

Blumenfeld

et al. 2024

Preprint

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Background and purpose The objective is to demonstrate feasibility of quantitative susceptibility mapping (QSM) in autosomal dominant polycystic kidney disease (ADPKD) patients and to compare imaging findings with traditional T1/T2w magnetic resonance imaging (MRI). Methods Thirty-three consecutive patients (11 male, 22 female) diagnosed with ADPKD were initially selected. QSM images were reconstructed from the multiecho gradient echo data and compared to co-registered T2w, T1w and CT images. Complex cysts were identified and classified into distinct subclasses based on their imaging features. Prevalence of each subclass was estimated. Results QSM visualized two renal calcifications measuring 9 and 10 mm, and three pelvic phleboliths measuring 2 mm but missed 24 calcifications measuring 1mm or less and 1 larger calcification at the edge of the field of view. A total of 121 complex T1 hyperintense/T2 hypointense renal cysts were detected. 52 (43%) cysts appeared hyperintense on QSM consistent with hemorrhage; 60 (49%) cysts were isointense with respect to simple cysts and normal kidney parenchyma, while the remaining 9 (7%) were hypointense. The presentation of the latter two complex cyst subtypes is likely indicative of proteinaceous composition without hemorrhage. Conclusions Our results indicate that QSM of ADPKD kidneys is possible and uniquely suited to detect large renal calculi without ionizing radiation, and able to identify properties of complex cysts unattainable with traditional approaches.

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Section: Discussionmentioning

confidence: 99%

Quantitative susceptibility mapping for detection of kidney stones, hemorrhage differentiation and cyst classification in ADPKD

Schumacher,

Prince,

Blumenfeld

et al. 2024

Preprint

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“…Notably, since 2019, in addition to popular research topics such as “quantitative MRI” and “myelin water imaging”, “neuromyelitis optica spectrum”, “spectrum”, and “neuromyelitis optica” have appeared frequently in this field, suggesting that new research directions have emerged in recent years. Research on the quantitative analysis of MS myelin has mainly focused on the differential diagnosis of neuromyelitis optica, myelin-oligodendrocyte glycoprotein (MOG-IgG) antibody-associated diseases, and other antibody-mediated inflammatory diseases, yielding new discoveries and achieving research progress, which has improved the accuracy of diagnoses ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of myelin imaging studies of patients with multiple sclerosis (2000–2022)

Chen,

Zhang,

Shen

et al. 2024

Quant Imaging Med Surg

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Background Multiple sclerosis (MS) is a condition that can impact the central nervous system (CNS) and cause damage to the myelin, which is responsible for facilitating the normal transmission of electrical impulses along the nerves. We performed a bibliometric analysis of the scientific publications on myelin imaging in MS to reveal the development trends in this field and to evaluate research trends in myelin imaging in MS. Methods The Web of Science Core Collection was searched for articles related to myelin imaging in MS published between January 2000 and December 2022. CiteSpace, VOSviewer, and R language were used to evaluate and visualize contributions by and co-occurrence relationships among countries and institutions, authors, journals, citations, keywords, and so on. Results A total of 1,639 articles addressed the topic of myelin imaging in MS. The United States had the largest number of annual publications. The University of London was the institution with the highest number of publications (n=118) and citations (n=9,885). The top 3 productive authors were all from the University of British Columbia in Canada. An article published by Mackay et al. in 1994 had the most citations (n=272). Neuroimage [impact factor (IF) =7.40, Journal Citation Reports quartile 1 (Q1)] was the most productive journal in terms of the number of articles relating to myelin imaging in MS (n=149). In recent years, myelin water imaging, synthetic magnetic resonance imaging (SyMRI), inhomogeneous magnetization, positron emission tomography (PET) imaging, and aquaporin-4 (AQP4) have been researched hotspots of myelin imaging in MS. Conclusions With advancements in the pathophysiological research on myelin changes in MS, myelin imaging is playing an important role in the diagnosis and treatment of MS. In addition, the use of new sequences of myelin imaging to distinguish MS from other inflammatory demyelinating diseases is a future development trend in this field.

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“…These models consider a linear dependence of the reversible transverse relaxation rate on absolute magnetic susceptibility, which holds under the static dephasing regime approximation (Yablonskiy and Haacke, 1994). Such susceptibility source separation methods have shown promising applications to characterize multiple sclerosis lesions (Dimov et al, 2022a; Emmerich et al, 2021; Kim et al, 2023; Straub et al, 2023), and to investigate protein aggregation or demyelination in AD (Ahmed et al, 2023). The DECOMPOSE-QSM method proposed by Chen et al (2021) uses three-pool complex exponentials to model the signal evolution based solely on multi-echo gradient echo (GRE) data and derive maps of paramagnetic component and diamagnetic component susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation

Joshi,

Yao,

Kakazu

et al. 2024

Preprint

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Tauopathies, including Alzheimer's disease (AD), are neurodegenerative disorders characterized by hyperphosphorylated tau protein aggregates in the brain. In addition to protein aggregates, microglia-mediated inflammation and iron dyshomeostasis are other pathological features observed in AD and other tauopathies. It is known that these alterations at the subcellular level occur much before the onset of macroscopic tissue atrophy or cognitive deficits. The ability to detect these microstructural changes with MRI therefore has substantive importance for improved characterization of disease pathogenesis. In this study, we demonstrate that quantitative susceptibility mapping (QSM) with paramagnetic and diamagnetic susceptibility source separation has the potential to distinguish neuropathological alterations in a transgenic mouse model of tauopathy. 3D multi-echo gradient echo data were acquired from fixed brains of PS19 (Tau) transgenic mice and age-matched wild-type (WT) mice (n = 5 each) at 11.7 T. The multi-echo data were fit to a 3-pool complex signal model to derive maps of paramagnetic component susceptibility (PCS) and diamagnetic component susceptibility (DCS). Group-averaged signal fraction and composite susceptibility maps showed significant region-specific differences between the WT and Tau mouse brains. Significant bilateral increases in PCS and |DCS| were observed in specific hippocampal and cortical sub-regions of the Tau mice relative to WT controls. Comparison with immunohistological staining for microglia (Iba1) and phosphorylated-tau (AT8) further indicated that the PCS and DCS differences corresponded to regional microgliosis and tau deposition in the PS19 mouse brains, respectively. The results demonstrate that quantitative susceptibility source separation may provide sensitive imaging markers to detect distinct pathological alterations in tauopathies.

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χ-Separation Imaging for Diagnosis of Multiple Sclerosis versus Neuromyelitis Optica Spectrum Disorder

Cited by 21 publications

References 35 publications

Quantitative susceptibility mapping for detection of kidney stones, hemorrhage differentiation and cyst classification in ADPKD

Quantitative susceptibility mapping for detection of kidney stones, hemorrhage differentiation and cyst classification in ADPKD

Bibliometric analysis of myelin imaging studies of patients with multiple sclerosis (2000–2022)

Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation

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