ω-3 and folic acid act against depressive-like behavior and oxidative damage in the brain of rats subjected to early- or late-life stress

Réus, Gislaine Z.; Maciel, Amanda L.; Abelaira, Helena M.; Moura, Airam B. de; Souza, Thays G. de; Santos, Thais R. dos; Darabas, Ana Caroline; Parzianello, Murilo; Matos, Danyela; Abatti, Mariane; Vieira, Ana Carolina Santana; Fucillini, Vanessa; Michels, Monique; Dal‐Pizzol, Felipe; Quevedo, Joao L De

doi:10.1016/j.nut.2018.03.006

Cited by 41 publications

(29 citation statements)

References 80 publications

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“…In addition to their effects on the immune system, supplementation of ω-3 fatty acids in adulthood can reduce anxiety-like and depression-like behaviors following adolescent LPS injections [151]. Consistent with the behavioral outcomes found in adulthood, early-life supplementation of ω-3 has been shown to prevent increases in anxiety-like and depression-like behavior following ELS [152,153]. Moreover, ω-3 fatty acid supplementation during gestation and early life has been shown to prevent alterations to the development of microglia in the HIP, while also reducing cognitive deficits following ELS [55,154].…”

Section: Early Preventative Interventionsmentioning

confidence: 53%

Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development

Catale

Gironda

Iacono

et al. 2020

JCM

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The putative effects of early-life stress (ELS) on later behavior and neurobiology have been widely investigated. Recently, microglia have been implicated in mediating some of the effects of ELS on behavior. In this review, findings from preclinical and clinical literature with a specific focus on microglial alterations induced by the exposure to ELS (i.e., exposure to behavioral stressors or environmental agents and infection) are summarized. These studies were utilized to interpret changes in developmental trajectories based on the time at which the stress occurred, as well as the paradigm used. ELS and microglial alterations were found to be associated with a wide array of deficits including cognitive performance, memory, reward processing, and processing of social stimuli. Four general conclusions emerged: (1) ELS interferes with microglial developmental programs, including their proliferation and death and their phagocytic activity; (2) this can affect neuronal and non-neuronal developmental processes, which are dynamic during development and for which microglial activity is instrumental; (3) the effects are extremely dependent on the time point at which the investigation is carried out; and (4) both pre- and postnatal ELS can prime microglial reactivity, indicating a long-lasting alteration, which has been implicated in behavioral abnormalities later in life.

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Section: Early Preventative Interventionsmentioning

confidence: 53%

Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development

Catale

Gironda

Iacono

et al. 2020

JCM

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“…A randomized controlled trial showed that long-term, highdose, daily supplementation with FA, vitamin B6, vitamin B12 could not reduce the overall depression risk in middle aged and older women [7]. In several animal experiments, FA supplement alone [8] or combined with other nutrients (-zinc [9] or omega-3 fatty acids [10]) exerted significant antidepressant effects on rats.…”

Section: Introductionmentioning

confidence: 99%

Folic acid ameliorates depression-like behaviour in a rat model of chronic unpredictable mild stress

2020

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Background: Depression is characterized by significant and low mood. Classical antidepressants are still not adequate in treating depression because of undesirable side effects. Folic acid, a member of the vitamin B complex, in considered to be strongly associated with the function and development of the central nervous system. Thus, in this study, we established a model of depression through chronic unpredictable mild stress (CUMS) in rats and assessed the antidepressant effects and mechanisms of folic acid. Methods: Sprague-Dawley rats were randomly divided into four groups: control, chronic unpredictable mild stress (CUMS), CUMS treated with folic acid, and CUMS treated with citalopram. Rats were assessed in terms of weight change, open-field test and sucrose preference. Homocysteine, monoamine neurotransmitters, interleukin-6, brainderived neurotrophic factor (BDNF), β-endorphin levels in the serum and brains of rats were analysed. Results: Folic acid exhibited antidepressant-like effects in open-field and sucrose preference tests. Folic acid treatment effectively increased the levels of monoamine neurotransmitters, BDNF and β-endorphin, interleukin-6 and homocysteine levels were also significantly suppressed by folic acid administration. Conclusions: These findings serve as preclinical evidence that folic acid plays an antidepressant-like role in several pathways involving monoamine neurotransmitters. Thus, folic acid may be used as a potential antidepressant.

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“…This suggests that increased levels of FABP7 are in certain diseases a defense mechanism of the cell against stress, Table 1 . Probably, FABP7, a strong binder of omega-3 PUFAs, causes an inhibition of the behavioral and brain changes that occur as a consequence of stressful life events (Réus et al 2018 ; Sharifi et al 2011 ). FABP7 appears to have a protective role against neuronal toxicity and it can be considered as a diagnostic marker for the detection of brain injury from trauma or neurodegenerative diseases (Pelsers and Glatz 2005 ; Teunissen et al 2011 ).…”

Section: Fabp Chaperonopathiesmentioning

confidence: 99%

Lipid chaperones and associated diseases: a group of chaperonopathies defining a new nosological entity with implications for medical research and practice

D’Anneo

Bavisotto

Gammazza

et al. 2020

Cell Stress and Chaperones

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Fatty acid–binding proteins (FABPs) are lipid chaperones assisting in the trafficking of long-chain fatty acids with functions in various cell compartments, including oxidation, signaling, gene-transcription regulation, and storage. The various known FABP isoforms display distinctive tissue distribution, but some are active in more than one tissue. Quantitative and/or qualitative changes of FABPs are associated with pathological conditions. Increased circulating levels of FABPs are biomarkers of disorders such as obesity, insulin resistance, cardiovascular disease, and cancer. Deregulated expression and malfunction of FABPs can result from genetic alterations or posttranslational modifications and can be pathogenic. We have assembled the disorders with abnormal FABPs as chaperonopathies in a distinct nosological entity. This entity is similar but separate from that encompassing the chaperonopathies pertaining to protein chaperones. In this review, we discuss the role of FABPs in the pathogenesis of metabolic syndrome, cancer, and neurological diseases. We highlight the opportunities for improving diagnosis and treatment that open by encompassing all these pathological conditions within of a coherent nosological group, focusing on abnormal lipid chaperones as biomarkers of disease and etiological-pathogenic factors.

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ω-3 and folic acid act against depressive-like behavior and oxidative damage in the brain of rats subjected to early- or late-life stress

Cited by 41 publications

References 80 publications

Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development

Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development

Folic acid ameliorates depression-like behaviour in a rat model of chronic unpredictable mild stress

Lipid chaperones and associated diseases: a group of chaperonopathies defining a new nosological entity with implications for medical research and practice

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