ω-3 Fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain

Maroon, Joseph C.; Bost, Jeffrey

doi:10.1016/j.surneu.2005.10.023

Cited by 137 publications

(92 citation statements)

References 28 publications

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“…Omega-3 fatty acid molecules are naturally released from injured cell membranes and competitively inhibit proinflammatory cytokines, including IL-1, IL-6, IL-12, and TNF-a [13]. Given their antiinflammatory mechanism of action, studies have compared omega-3 fatty acids with NSAIDs and found equivalent pain relief for chronic back pain with less side effects, including decreased bleeding risk [13,57]. This is an evolving area of investigation that will continue to develop as the market for supplements continues to grow.…”

Section: Oral Treatmentsmentioning

confidence: 99%

Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

Kadow

Sowa

et al. 2015

Clinical Orthopaedics &Amp; Related Research

220

197

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Background Intervertebral disc degeneration is a common condition with few inexpensive and effective modes of treatment, but current investigations seek to clarify the underlying process and offer new treatment options. It will be important for physicians to understand the molecular basis for the pathology and how it translates to developing clinical treatments for disc degeneration. In this review, we sought to summarize for clinicians what is known about the molecular processes that causes disc degeneration.

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Section: Oral Treatmentsmentioning

confidence: 99%

Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

Kadow

Sowa

et al. 2015

Clinical Orthopaedics &Amp; Related Research

220

197

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“…In both preclinical and clinical studies, omega-3 PUFAs have been shown to contribute to the reduction of inflammatory pain in different situations, such as inflammatory bowel disease [83], chronic headaches [84], knee osteoarthritis [85,86], inflammatory joint pain [81], neck or back pain (discogenic pain) [87], rheumatoid arthritis [88 -96] neuropathic pain [82,97], musculoskeletal injury [98] and dysmenorrhea [99]. In these clinical studies, different effective doses of fish oils (DHA and EPA) and treatment times were utilized Table (1), with other preclinical studies also having revealed the antinociceptive effect of different types of omega-3 PUFAs [100 -102].…”

Section: Omega-3 Fatty Acids Combined With Morphinementioning

confidence: 99%

Innovations in Pain Management: Morphine Combined with Omega-3 Fatty Acids

Laino¹

2017

Open Conf. Proceed. J.

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Abstract:The treatment of acute and chronic severe pain remains a common major challenge faced by clinicians working with the general population, and even after the application of recent advances to treatments, there may still continue to be manifestations of adverse effects.Chronic pain affects the personal and social life of the patient, and often also their families. In some cases, after an acute pain the patient continues to experience chronic pain, which can be a result of diseases such as cancer.Morphine is recommended as the first choice opioid in the treatment of moderate to severe acute and chronic pain. However, the development of adverse effects and tolerance to the analgesic effects of morphine often leads to treatment discontinuation. The present work reviews the different pharmaceutical innovations reported concerning the use of morphine. First, its utilization as the first medication for the treatment of moderate to severe cancer pain and non-cancer pain in patients is evaluated, taking into account the most common complications and adverse effects. Next, strategies utilized to manage these side effects are considered, and we also summarize results using omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) as a monotherapy or as an adjunct to morphine in the treatment of pain.

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“…No significant side effects have been recorded and no safety issues have also been indicated in many of the studies involving use of resveratrol. Possible anti-platelet effect is suggested, hence, there is need for proper care when using other key prescription drugs or coagulation interfering products [93][94][95][96][97][98].…”

Section: Herbal Remedies With Potential Anti-arthritic Activitiesmentioning

confidence: 99%

Evidence Based Targeting of Cytokines for Conventional and the Potential Phytotherapies in Management of Rheumatoid Arthritis

Mutua¹,

Kk²,

Mr³

et al. 2017

J Arthritis

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Rheumatoid arthritis is an autoimmune disease that leads to chronic, systemic inflammatory reaction that primarily affects synovial joints. Current cytokine based therapies are effective and safe. However, they have a challenge of having short plasma half-life and even higher doses are required to manage the conditions. The processes involved in production using phage and viral technologies are expensive. Herbal medicines have been used for long and are considered safe and effective as medicines for many inflammatory related diseases. Many plants also posit as a potent anti-inflammatory agents. Evidence for use of herbal plants in both human and animal trials in studies suggest significant potential of application in herbal formulation in management of rheumatoid arthritis. Specifically, many studies suggest the direct effect of managing the agents of inflammation as a way of managing rheumatoid arthritis. Most evidence links the involvement of pro-inflammatory cytokines (interleukin-1, TNF-α, IFN-α, and NF-кB) to the long term. It has also been suggested that the use of protective cytokines such as (Interleukin-4, Interleukin-6, Interleukin-8). Key pathways involve cyclooxygenase 1 and 2, 5-Lipooxygenase, formations of metalloproteinases, and inhibition of formation of prostaglandin E2. Use of herbal medicines has potential of improving joint conditions in rheumatoid arthritis. Use of herbal extracts offers better, cheap and affordable solution for long term management of rheumatoid arthritis in patients. They also show potential of offering multifunctional approaches to the management of the conditions through their anti-oxidative and anti-inflammatory mechanisms. Further studies are required to demonstrate the mechanisms involved in activation of protective cytokines in the management of rheumatoid arthritis.

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ω-3 Fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain

Cited by 137 publications

References 28 publications

Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

Innovations in Pain Management: Morphine Combined with Omega-3 Fatty Acids

Evidence Based Targeting of Cytokines for Conventional and the Potential Phytotherapies in Management of Rheumatoid Arthritis

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