ω-Hydroxypalmitic and α,ω-Hexadecanedioic Acids As Activators of Free Respiration and Inhibitors of H2O2 Generation in Liver Mitochondria

Semenova, Alena A.; Самарцев, В. Н.; Павлова, С. И.; Dubinin, Mikhail V.

doi:10.1134/s1990747819060084

Cited by 7 publications

(3 citation statements)

References 28 publications

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“…In particular, a promising direction seems to be research aimed at elucidating the relationship between the Ca 2+ -ionophore effect of bile acids and their action as potential modulators of nonspecific permeability of the inner mitochondrial membrane and, as a consequence, cell death. As noted above, protonophore uncouplers are able to suppress the formation of reactive oxygen species in mitochondria [ 70 , 74 , 75 , 76 ]. It is not known whether free (non-conjugated) bile acids have a similar effect.…”

Section: Discussionmentioning

confidence: 99%

“…These uncouplers, by increasing the proton conductivity of the inner mitochondrial membrane and thus dissipating the proton motive force (Δ p ), stimulate respiration and reduce the efficiency of oxidative ATP synthesis (reduce the ADP/O and respiratory control ratios) [ 72 , 73 ]. Protonophore uncouplers also have the ability to inhibit the production of reactive oxygen species by mitochondria [ 72 , 74 , 75 , 76 ]. These and similar compounds are able to cross the phospholipid membrane in both protonated and anionic form due to the presence of a delocalized negative charge.…”

Section: Effect Of Bile Acids On the Permeability Of Biological And A...mentioning

confidence: 99%

“…Perhaps the most fully studied natural protonophore uncouplers of oxidative phosphorylation are free monocarboxylic fatty acids [ 68 , 75 , 76 , 77 , 78 , 79 , 80 ]. It has been established that carrier proteins of the inner mitochondrial membrane that carry out the exchange transport of ADP to ATP (ADP/ATP-antiporter) are involved in the uncoupling effect of monocarboxylic fatty acids in mitochondria of vital organs of mammals (heart, liver, kidneys, skeletal muscles) [ 72 , 78 , 80 , 81 , 82 , 83 ].…”

Section: Effect Of Bile Acids On the Permeability Of Biological And A...mentioning

confidence: 99%

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Bile Acids as Inducers of Protonophore and Ionophore Permeability of Biological and Artificial Membranes

et al. 2023

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It is now generally accepted that the role of bile acids in the organism is not limited to their participation in the process of food digestion. Indeed, bile acids are signaling molecules and being amphiphilic compounds, are also capable of modifying the properties of cell membranes and their organelles. This review is devoted to the analysis of data on the interaction of bile acids with biological and artificial membranes, in particular, their protonophore and ionophore effects. The effects of bile acids were analyzed depending on their physicochemical properties: namely the structure of their molecules, indicators of the hydrophobic–hydrophilic balance, and the critical micelle concentration. Particular attention is paid to the interaction of bile acids with the powerhouse of cells, the mitochondria. It is of note that bile acids, in addition to their protonophore and ionophore actions, can also induce Ca2+-dependent nonspecific permeability of the inner mitochondrial membrane. We consider the unique action of ursodeoxycholic acid as an inducer of potassium conductivity of the inner mitochondrial membrane. We also discuss a possible relationship between this K+ ionophore action of ursodeoxycholic acid and its therapeutic effects.

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