Ω-Shaped fiber optic LSPR coated with hybridized nanolayers for tumor cell sensing and photothermal treatment

Kong, Xinyu; Li, Mingyue; Xiao, Wei; Li, Yongxin; Luo, Zewei; Shen, Ji-Wei; Duan, Yixiang

doi:10.1016/j.talanta.2024.126381

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Cited by 5 publications

References 36 publications

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Ascorbic Acid Detection Using Gold Nanoparticles and Graphene Oxide–Coated SMS Optical Fiber–Based Sensor

Gupta,

Choudhary,

Kumar

2024

Plasmonics

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Ascorbic Acid Detection Using Gold Nanoparticles and Graphene Oxide–Coated SMS Optical Fiber–Based Sensor

Gupta,

Choudhary,

Kumar

2024

Plasmonics

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A disposable fiber-optic plasmonic sensor for chemical sensing

Han,

Zhang,

et al. 2025

Analytical Biochemistry

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Sandwich Layer-Modified Ω-Shaped Fiber-Optic LSPR Enables the Development of an Aptasensor for a Cytosensing–Photothermal Therapy Circuit

Kong,

He,

et al. 2024

ACS Sens.

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The metastasis of cancer cells is a principal cause of morbidity and mortality in cancer. The combination of a cytosensor and photothermal therapy (PTT) cannot completely eliminate cancer cells at one time. Hence, this study aimed to design a localized surface plasmonic resonance (LSPR)-based aptasensor for a circuit of cytosensing–PTT (COCP). This was achieved by coating a novel sandwich layer of polydopamine/gold nanoparticles/polydopamine (PDA/AuNPs/PDA) around the Ω-shaped fiber-optic (Ω-FO). The short-wavelength peak of the sandwich layer with strong resonance exhibited a high refractive index sensitivity (RIS). The modification with the T-shaped aptamer endowed FO-LSPR with unique characteristics of time-dependent sensitivity enhancement behavior for a sensitive cytosensor with the lowest limit of detection (LOD) of 13 cells/mL. The long-wavelength resonance peak in the sandwich layer appears in the near-infrared region. Hence, the rate of increased localized temperature of FO-LSPR was 160 and 30-fold higher than that of the bare and PDA-coated FO, indicating strong photothermal conversion efficiency. After considering the localized temperature distribution around the FO under the flow environment, the FO-LSPR-enabled aptasensor killed 77.6% of cancer cells in simulated blood circulation after five cycles of COCP. The FO-LSPR-enabled aptasensor improved the efficiency of the cytosensor and PTT to effectively kill cancer cells, showing significant potential for application in inhibiting cancer metastasis.

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Ω-Shaped fiber optic LSPR coated with hybridized nanolayers for tumor cell sensing and photothermal treatment

Cited by 5 publications

References 36 publications

Ascorbic Acid Detection Using Gold Nanoparticles and Graphene Oxide–Coated SMS Optical Fiber–Based Sensor

Ascorbic Acid Detection Using Gold Nanoparticles and Graphene Oxide–Coated SMS Optical Fiber–Based Sensor

A disposable fiber-optic plasmonic sensor for chemical sensing

Sandwich Layer-Modified Ω-Shaped Fiber-Optic LSPR Enables the Development of an Aptasensor for a Cytosensing–Photothermal Therapy Circuit

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