ω3PUFAs improve hepatic steatosis in postnatal overfed rats and HepG2 cells by inhibiting acetyl‐CoA carboxylase

Zhou, Nan; Du, Shisuo; Dai, Yulin; Yang, Fan; Li, Xiaonan

doi:10.1002/fsn3.2482

Cited by 5 publications

(3 citation statements)

References 64 publications

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“…SREBP-1c is a major regulator of fatty acid synthesis in the liver. It can regulate enzymes or proteins related to fatty acid synthesis such as ACC [ 37 ]. In the HFD group, the mRNA expression levels of SREBP-1c and ACC in the livers of mice were remarkably increased, while the mRNA expression levels of SREBP-1c and ACC were substantially decreased by B. lactis SF ( Figure 3 ).…”

Section: Resultsmentioning

confidence: 99%

In Vitro Probiotic Properties of Bifidobacterium animalis subsp. lactis SF and Its Alleviating Effect on Non-Alcoholic Fatty Liver Disease

Tao

Peng

et al. 2023

Nutrients

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Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease with many influencing factors. With the increasing role of the gut–liver axis in various liver diseases, research on the prevention and treatment of NAFLD with probiotics is increasing. In the present study, a Bifidobacterium animalis subsp. strain, B. lactis SF, was isolated from the feces of healthy infants and characterized by sequencing of the 16S rDNA. A systematic probiotic evaluation was carried out, and a diet-induced mouse model was constructed to study the effect and mechanism of B. lactis SF on diet-induced NAFLD. Results show that B. lactis SF has excellent gastrointestinal fluid tolerance and intestinal colonization, and strong antibacterial and antioxidant capabilities. In vivo, B. lactis SF modulated intestinal flora, restored the intestinal barrier, and inhibited LPS entrance into the portal circulation, which subsequently inhibited the TLR4/NF-κB and modulated the PI3K-Akt/AMPK signaling pathway, attenuated the inflammatory response, and reduced lipid accumulation. In addition, B. lactis SF attenuated oxidative stress and further alleviated autophagy, resulting in an ameliorative effect on NAFLD. Therefore, our study provides a new dietary method for the treatment of NAFLD.

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Section: Resultsmentioning

confidence: 99%

In Vitro Probiotic Properties of Bifidobacterium animalis subsp. lactis SF and Its Alleviating Effect on Non-Alcoholic Fatty Liver Disease

Tao

Peng

et al. 2023

Nutrients

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“…In a cross‐sectional study, nut consumption was associated with a lower risk of NAFLD (calculated by FLI) in older adults (Tan et al, 2021 ). In another study, it was reported that an omega‐3 PUFA‐rich diet (fish oil diet) reduced the risk of NAFLD by inhibiting acetyl‐CoA carboxylase and sterol regulatory element‐binding protein‐1c (SREBP‐1c) (Zhou et al, 2021 ). Khan and Jackson ( 2018 ) found a significant relationship between pro‐inflammatory omega‐6 FAs intake and FBS, triglyceride, and cholesterol.…”

Section: Discussionmentioning

confidence: 99%

Relationship between diet quality and nonalcoholic fatty liver disease predictor indices in Iranian patients with metabolic syndrome: A cross‐sectional study

Taghdir

Salehi

Parastouei

et al. 2023

Food Science & Nutrition

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The present study aimed to assess the association between diet quality and nonalcoholic fatty liver disease (NAFLD) predictor indices in patients with metabolic syndrome (MetS). This cross‐sectional study was carried out among 344 adult patients with MetS. The diet quality of patients was calculated by Healthy Eating Index‐2015 (HEI‐2015). NAFLD predictor indices (Hepatic Steatosis Index [HSI], Triglyceride‐Glucose Index [TyG], and Fatty Liver Index [FLI]) were calculated and compared according to the HEI‐2015 quartiles. The relationship between the HEI‐2015 score and HSI, FLI, and TyG Index was estimated using multiple linear regression analysis. The findings of the present study revealed that patients with the highest HEI score had the lowest FLI score (p = .003) and HSI score (p = .05). There was an inverse relationship between the HEI‐2015 score and FLI (β = −0.49; p < .001), HSI (β = −0.05; p = .25), and TyG Index (β = −0.002; p = .34). According to our result, after adjusting for possible confounding factors, there was a statistically significant inverse association between HEI‐2015 and FLI.

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“…One animal model designed to study the impact of childhood obesity was obtained by reducing the litter size from normal (eight to ten rat pups) to small (three to four offspring per dam) during the lactation period. This enables the offspring rat to suckle a higher quantity of milk when raised in a small litter (SL) compared with a normal litter (NL), resulting in a greater body weight gain [ 6 , 7 , 8 ] that is exacerbated after weaning when the animals receive high-density energy diets [ 9 ]. The overnutrition, overweight, and rapid growth that are produced in the infant rat under these conditions have a great influence on the health and metabolism of the adult animal [ 10 , 11 ], producing an increase in the prevalence of obesity, type 2 diabetes, metabolic syndrome, dyslipidemia, hypertension, and NAFLD developing in adulthood.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Functional Food Made with Salvia hispanica L. (Chia Seed), Amaranthus hypochondriacus L. (Amaranth), and an Ethanolic Extract of Curcuma longa L. (Curcumin) in a Rat Model of Childhood Obesity

Rivero-Salgado,

Zamudio,

Fregoso-Aguilar

et al. 2024

Foods

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Obesity is a global health problem and is increasing in prevalence in most countries. Although obesity affects all age groups, children are the most vulnerable sector. Functional foods are novel formulated foods containing substances (i.e., nutrients, phytochemicals, probiotics, etc.) that have potential health-enhancing or disease-preventing value. The research objective was to study the possible beneficial effects of providing a functional food made with amaranth flour, chia seed, and curcumin extract on the metabolism and behavior of a rat model of childhood obesity. Male Wistar rat pups from two litters of different sizes, a normal litter (NL) (10 pups) and a small litter (SL) (4 pups), were used. After weaning, the rats were fed a hypercaloric diet (HD) or an HD supplemented with the functional food mixture. Body weight and energy intake were measured for seven weeks, and locomotor activity, learning, and memory tests were also performed. At the end of the experiment, glucose and lipid metabolism parameters were determined. The results showed that in this model of obesity produced by early overfeeding and the consumption of a hypercaloric diet, anxiety-like behaviors and metabolic alterations occurred in the rat offspring; however, the provision of the functional food failed to reduce or prevent these alterations, and an exacerbation was even observed in some metabolic indicators. Interestingly, in the NL rats, the provision of the functional food produced some of the expected improvements in health, such as significant decreases in body weight gain and liver cholesterol and non-significant decreases in adipose tissue and leptin and insulin serum levels.

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ω3PUFAs improve hepatic steatosis in postnatal overfed rats and HepG2 cells by inhibiting acetyl‐CoA carboxylase

Cited by 5 publications

References 64 publications

In Vitro Probiotic Properties of Bifidobacterium animalis subsp. lactis SF and Its Alleviating Effect on Non-Alcoholic Fatty Liver Disease

In Vitro Probiotic Properties of Bifidobacterium animalis subsp. lactis SF and Its Alleviating Effect on Non-Alcoholic Fatty Liver Disease

Relationship between diet quality and nonalcoholic fatty liver disease predictor indices in Iranian patients with metabolic syndrome: A cross‐sectional study

Effects of a Functional Food Made with Salvia hispanica L. (Chia Seed), Amaranthus hypochondriacus L. (Amaranth), and an Ethanolic Extract of Curcuma longa L. (Curcumin) in a Rat Model of Childhood Obesity

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