The article attempts to econometric modeling of the influence of a complex of factors on the volume and dynamics of the economies of the member States of the European Union, taking into account their differentiation. The main results of the author’s research are as follows. First, the fundamental coincidence of trends in the EU GDP dynamics with global trends and the presence of a strong negative impact on this dynamics of the global crisis of the late 2000s have been established. Secondly, it is once again confirmed that there is a significant differentiation between the founding States of the EU and the countries that joined it after 1990, expressed in a significant excess of macroeconomic indicators of the first group of countries of similar indicators of the second group. Thirdly, the difference between the combinations of factors influencing economic development in the two groups of EU countries is revealed, which once again testifies to the bloc nature of the EU structure.