Апікальна Гіпертрофічна Кардіоміопатія. Клінічний Випадок І Огляд Літератури

Nesukai, Ye.G.; Adarichev, Valeriy; Titov, Ye. Yu.; Giresh, I. I.

doi:10.22141/2224-1485.1.51.2017.96251

Cited by 2 publications

(1 citation statement)

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“…Распространенность АГКМП в Японии составляет 13-25 %, в европейской популяции -3-11 % среди пациентов с ГКМП [11]. При АГКМП нет обструкции ВТЛЖ, а систолический градиент в полости ЛЖ отсутствует как при нагрузке, так и в покое [17,18]. Лечение включает медикаментозную терапию (антиагреганты, бета-адреноблокаторы, антагонисты рецепторов ангиотензина II, диуретики, ранолазин.)…”

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Diagnosis and treatment of apical hypertrophic cardiomyopathy of the left ventricle

et al. 2022

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This article presents a case of diagnosis and treatment of a rare form of left ventricular (LV) hypertrophic cardiomyopathy (HCMP), asymmetric topical HCMP without obstruction of the LV outflow tract, and raises the issue of diagnosis and treatment of rare forms of this disease. In the Federal Center for Cardiovascular Surgery in 2019–2020, 5 cases of asymmetric hypertrophic apical cardiomyopathy were observed and documented with echocardiography (EchoCG), cardiac magnetic resonance imaging (MRI), and Holter ECG monitoring. A 60-year-old female patient underwent a comprehensive evaluation, including physical examination, EchoCG, MRI, Holter ECG monitoring, and coronary angiography. Apical HCMP was detected. The clinical picture was explainable from the perspective of functional and structural alterations in the LV myocardium, where full obstruction of the cardiac apex develops during systole. The small LV cavity is unable to provide effective hemodynamics. Changed small coronary arteries also contribute to this disorder, which, in results, affects myocardial oxygen supply. The administered therapy included antiplatelets, beta-blockers, angiotensin II receptor blockers, diuretics, and ranolazine. The effect of therapy was assessed as positive. Risk of sudden death, according to European Guidelines, 2014 was 0.86 %.

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Diagnosis and treatment of apical hypertrophic cardiomyopathy of the left ventricle

et al. 2022

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Prognostic value of left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy

Tseluyko

Butko

Kinoshenko³

2022

Actual Problems of Modern Medicine

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ABSTRACT. Hypertrophic cardiomyopathy (HCM) is one of the widespread genetically determined diseases of the myocardium, which is accompanied by the development of diastolic and, subsequently, systolic dysfunction of the myocardium. The aim of our study was to evaluate the clinical and instrumental features of patients with hypertrophic cardiomyopathy with impaired left ventricular global longitudinal strain (GLS) and its prognostic value for the development of cardiovascular events in the Ukrainian population of patients with hypertrophic cardiomyopathy. Materials and methods. The data of 35 patients with hypertrophic cardiomyopathy who underwent a comprehensive clinical and instrumental examination with determination of the absolute global longitudinal strain on speckle-tracking echocardiography were retrospectively analyzed. The patients were divided into two groups: Group I (GLS< 14.5) and Group II (GLS≥ 14.5). Results. A decrease in global longitudinal strain was associated with a longer disease duration (8 (5-11) vs 3 (2-5) years, p=0.003), increasing of complaints on irregularity of heart beat (66.7% vs 23.5%, p= 0.018) and weakness (61.1% vs 23.5%, p=0.04), increased systolic blood pressure (SBP) (130 (120-140) vs 110 (100-120) mm Hg, p= 0.009), the absence of patients without signs of heart failure (0 vs 29.4%, p=0.019), an increase in IVRT (106.19±28.62 vs 84.57±27.54 ms, p=0.044) and a greater number of ventricular extrasystoles (17 (4-69) vs 2 (0.5-3), p=0.014). According to the Kaplan-Meier analysis of survival in relation to fatal and non-fatal cardiovascular events or their combination with hospitalization for heart failure, they had significantly worse survival rates (Log-Rank, p=0.016 and p=0.003). Conclusions. Hypertrophic cardiomyopathy patients with poor global longitudinal strain scores were characterized by worse clinical and instrumental data and an unfavorable cardiovascular prognosis.

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Апікальна Гіпертрофічна Кардіоміопатія. Клінічний Випадок І Огляд Літератури

Cited by 2 publications

References 55 publications

Diagnosis and treatment of apical hypertrophic cardiomyopathy of the left ventricle

Diagnosis and treatment of apical hypertrophic cardiomyopathy of the left ventricle

Prognostic value of left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy

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