Везикулярные Системы Доставки Биологически Активных Соединений: От Липосом К Керасомам

Дениева, З. Г.; Буданова, У. А.; Себякин, Ю. Л.

doi:10.31857/s0233475520060043

Cited by 2 publications

(1 citation statement)

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“…История открытия и использования липосом началась в 60-е годы XX столетия с работ Алека Бенгхема и его коллег, которые экспериментировали с фосфолипидами в водных средах и обнаружили их способность образовывать мембраноподобные структуры [26]. В настоящее время липосомы широко используются в качестве биологических наноконтейнеров для транспорта лекарственных средств в онкологии [27,28], офтальмологии [29], дерматологии [30], генной терапии [31] и других областях медицины. К неоспоримым достоинствам липосом относятся их способность к биодеградации, низкая иммуногенность, способность взаимодействовать с клеточной мембраной, обеспечивая внутриклеточную доставку их содержимого [32].…”

Section: экспериментальные статьиunclassified

The Effect of Liposomes of Various Compositions on the Skin and Its Derivatives After II–IIIA Degree Thermal Burns

Pashkevich,

Vilyanen,

Marcinkevich

et al. 2024

Acta Naturae

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This study examines the pathological processes and conditions arising from an experimental modeling of II–IIIA degree thermal burns in laboratory animals. These conditions are characterized by skin structure defects, diminished skin functions, especially the barrier function, and damage to skin derivatives like hair follicles and sebaceous glands. We compared the effect of liposomes composed of soybean lecithin of 90% phosphatidylcholine content and liposomes composed of lecithin of 26% phosphatidylcholine content on the epidermis, dermis and its capillaries, hair follicles, and the sebaceous glands of the laboratory animals 24 h after experimental modeling of II–IIIA degree thermal skin burns. We discuss the dependency of liposome effects on the skin and its derivatives on the fatty acid composition of the lecithin used, with particular focus on phosphatidylinositol, phosphatidic acids, as well as oleic and linoleic acids.

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Section: экспериментальные статьиunclassified

The Effect of Liposomes of Various Compositions on the Skin and Its Derivatives After II–IIIA Degree Thermal Burns

Pashkevich,

Vilyanen,

Marcinkevich

et al. 2024

Acta Naturae

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Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review)

Zakharova,

Maganova,

Sinyashin

et al. 2023

Russ J Gen Chem

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The review focuses on the lipid based nanocarriers, with special attention paid to natural bioactive payloads. First, micelles and microemulsions are considered as very attractive colloidal nanocontainers that allow for marked improving the solubility of hydrophobic bioactives. Further, liposomal vehicles are reviewed, with both advantages and limitations discussed. Literature assay covers up-to-date information of about last three to five years, although brief background is given on the pioneer works addressing the liposomes and their evolution from bench to bedside. Final part of the review is devoted to the modern modifications of vesicular nanocarriers which can be adapted to specific administration way due to improved targeting properties, permeability, mucoadhesiveness and possibility to cross biological barriers. Therein, such kinds of nanocarriers as transfersomes, niosomes, ethosomes, chitosomes are evaluated; and separate sections focus on the natural based formulations, i.e., phytosomes and invasomes.

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Везикулярные Системы Доставки Биологически Активных Соединений: От Липосом К Керасомам

Cited by 2 publications

References 0 publications

The Effect of Liposomes of Various Compositions on the Skin and Its Derivatives After II–IIIA Degree Thermal Burns

The Effect of Liposomes of Various Compositions on the Skin and Its Derivatives After II–IIIA Degree Thermal Burns

Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review)

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