Вільнорадикальні Процеси В Організмі Свиней Під Дією Біологічно Активних Добавок

Buchko, O.

doi:10.29038/2617-4723-2015-313-143-150

Cited by 1 publication

(1 citation statement)

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“…The skin from rats' left side was a control, where we made one-time application of 0.9% saline solution (Kovalenko & Nedosekov, 2011). The compilation and recording of opsonophagocytic reaction with the study of phagocytic activity, phagocytic index and absolute complete phagocytosis of rat blood were performed according to V. V. Chumachenko modified method (Buchko, 2015). The modern human methods of laboratory animals care were used (Buckmaster, 2012).…”

Section: Methodsmentioning

confidence: 99%

Evaluation of acute toxicity of the "Orgasept" disinfectant

Kovalenko¹,

Пономаренко²,

Kukhtyn³

2020

Ukr J Ecol

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The purpose of the research was to study acute toxicity, irritating and sensitizing effects, biochemical and immunological parameters of animal blood after influence of "Orgasept" disinfectant, consisted from silver nanoparticles, benzalkonium chloride and lactic acid. To determine acute toxicity, 6 months old clinically healthy male rats (5 groups, six rats per each group) and female rats (5 groups, six per each group) with body weight of 180-200 g were used. We determined the average lethal dose (LD50) and the main parameters of acute toxicity after Orgasept rats administration in various dozes. We found that, at intra-gastrointestinal administration of Orgasept, the LD50 for male rats was 5000.0±43.0 mg/kg body weight and 5045.0±56.3 mg/kg for the females. We also registered that Orgasept does not have cumulative and sensitizing properties, does not show irritating effect, suppressive effect on growth and development of animals, and does not affect the hemopoiesis. We revealed that Orgasept demonstrated significant effect on nonspecific and specific factors of the organism's protection compared to the formaldehyde.

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Section: Methodsmentioning

confidence: 99%