Гематологічний Профіль У Щурів При Експериментальному Диклофенак-Індукованому Гепатиті

Gryshchenko, V. A.

doi:10.15421/2017_52

Cited by 4 publications

(5 citation statements)

References 17 publications

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“…Fatty liver disease has a number of histological and biochemical features. Among them is the accumulation of lipids in the cells of the liver parenchyma, which is a common feature of pathological conditions of all levels of severity in this disease (Younossi et al, 2016;Gryshchenko, 2017). This liver disease is considered the result of a metabolic syndrome, which, in addition to the accumulation of lipids in the liver tissue, is characterised by abdominal obesity, hyperglycemia, dyslipidemia ( Chalasani et al, 2018).…”

Section: Literature Reviewmentioning

confidence: 99%

“…However, these tests currently have several limitations, such as variability, insufficient accuracy, and risk factors for errors. The limitations and variability of these tests encourage researchers to combine them into diagnostic algorithms to produce more accurate tools (Gryshchenko, 2017;Bassal et al, 2022). Identifying patients with significant fibrosis is important for targeted therapy to prevent disease progression.…”

Section: Literature Reviewmentioning

confidence: 99%

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Phospholipid composition of bile and blood in rats under correction of experimental fatty hepatosis

Veselskyi,

Pototskyi,

Tomchuk

et al. 2023

Ukrainian journal of veterinary sciences

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To date, the aetiology and molecular mechanisms of the development of fatty hepatosis, which is quite common in mammals, have not yet been sufficiently explained. This pathology requires detailed study not only because of functional disorders of the liver and biliary system, but also because of the high probability of dangerous complications – fibrosis, cirrhosis, or hepatocellular carcinoma. The purpose of this study was to determine marker changes in the phospholipid composition of bile and blood in rats with experimental fatty hepatosis and with the use of corrective therapy. Hepatopathology was modelled in Wistar laboratory rats by intragastric administration of a 4% solution of tetracycline hydrochloride at the rate of 0.25 g/kg body weight for seven days. Using the method of thin-layer chromatography, the phospholipid components of animal bile and blood were studied. It was found that during experimental fatty hepatosis in rats, there was a decrease in the total phospholipid content in bile, mainly due to a decrease in the level of phosphatidylcholine (by 22.4-27.0%), the total fraction of inositol phosphatide and phosphatidylinositol (by 20.0-27.3%), and phosphatidylethanolamine (by 17.5-25.2%). Conversely, the introduction of milk phospholipids in the form of a dietary supplement “FLP-MD” in sick animals contributed to an increase in bile levels of phosphatidylserine by 67.1-99.8%, inositol phosphatide and phosphatidylinositol by 48.6-57.6%, phosphatidylcholine by 38.8-60.2%, phosphatidylethanolamine by 45.6-57.4%, and sphingomyelin by 30.4-46.3%. In the blood of such rats, a significant decrease in the content of phosphatidylcholine, phosphatidylserine, and sphingomyelin was found, which was not observed after administration of the “FLP-MD” dietary supplement to sick animals. In the case of using the supplement in healthy animals, only a 29.3% increase in the blood content of inositol phosphatide and phosphatidylinositol was noted. The determination of the most sensitive indicators in the phospholipid spectrum of blood and bile reveals the features of changes in molecular processes for the development of fatty hepatosis in animals, and also contributes to preclinical tests of the corrective effectiveness of newly created drugs according to established markers

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Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Phospholipid composition of bile and blood in rats under correction of experimental fatty hepatosis

Veselskyi,

Pototskyi,

Tomchuk

et al. 2023

Ukrainian journal of veterinary sciences

View full text Add to dashboard Cite

show abstract

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Untitled

2023

Ukrainian journal of veterinary sciences

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In the production of broiler poultry products, market operators use intensive technologies that involve the use of various, environmentally friendly nutraceuticals, in particular, probiotic preparations. In the technology of raising broiler chickens, probiotic preparations are necessary as a means for the prevention and treatment of gastrointestinal diseases, stimulating the growth and increasing the productivity of poultry. The purpose of the study is to investigate the effect of probiotic biologics on haematological parameters when it is fed to broiler chickens. The experiment used 20 broiler chickens, which were given a probiotic from 28 to 42 days in the following amounts: 0.5 g/10 dm 3 , 2.0 and 4.0 g/10 dm 3 of water. It was found that the morpho-biochemical parameters of poultry blood corresponded to the physiological standards for broiler chickens of the established age and confirmed the absence of pathophysiological changes in their body. On days 35 and 42 of rearing, an increase in the number of leukocytes from 4.4 to 17.2% and the haemoglobin content by 3.9 and 6.2%, respectively, was observed in the blood of broiler chickens fed the probiotic at a dose of 4.0 g/10 dm 3 compared to the control group. On day 35 of the study, a 1.2-fold increase in total serum protein was observed when drinking a probiotic in poultry, respectively, at doses of 2.0 and 4.0 g/10 dm 3 of water, and on day 42 -1.0 times for its drinking at a dose of 4.0 g/10 dm 3 of water. It was found that the content of inorganic calcium and phosphorus in the poultry blood serum corresponded to physiological limits, which indicates a sufficient level of mineral nutrition in the body of broiler chickens. The absence of changes in the activity of alanine aminotransferase and aspartate aminotransferase, the content of total lipids, cholesterol, and creatinine in the blood serum of broiler chickens of the experimental groups indicates the hepato-and nephronethoxicity of the probiotic. Based on the results obtained, the drug under study can be recommended to increase the resistance of the poultry body and regulate metabolism

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“…Основною характеристикою Диклофенаку натрію, як препарату є часткова розчинність в гідрофільному, та гідрофобному середовищі, нетривалий період напіввиведення із організму та швидке всмоктування за умови перорального використання [3]. Препарат отримав широке розповсюдження в якості анальгетика та протизапального засобу в різних галузях медицини, зокрема в хірургічній, травматологічній практиках (для знеболення після травм чи оперативних втручань), в неврології Диклофенак використовують при лікуванні корінцевих синдромів, мігрені, в акушерстві та гінекологіїдля лікування дисменореї та аднекситу; за рекомендаціями ВООЗ він посів перше місце в якості анальгетика в онкологічних пацієнтів та використовується впродовж тривалого часу, а подекуди роками [4].…”

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Influence of Toxic and Subtoxic Doses of Diclofenac Sodium on Mechanisms of Differentiation of Granulocytary Row Cells, Undifferentiated Blasts and Mitotic Cells in the Bone Marrow of Rats

Ivanov¹,

Bagmut²,

Tsapko³

et al. 2019

Ukr. ž. med. bìol. sportu

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Гематологічний Профіль У Щурів При Експериментальному Диклофенак-Індукованому Гепатиті

Cited by 4 publications

References 17 publications

Phospholipid composition of bile and blood in rats under correction of experimental fatty hepatosis

Phospholipid composition of bile and blood in rats under correction of experimental fatty hepatosis

Untitled

Influence of Toxic and Subtoxic Doses of Diclofenac Sodium on Mechanisms of Differentiation of Granulocytary Row Cells, Undifferentiated Blasts and Mitotic Cells in the Bone Marrow of Rats

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