Действие димерного аналога нетропсина 15Lys-bis-Nt и ацикловира на репродукцию вируса простого герпеса. Поиск вариантов вируса герпеса с лекарственной устойчивостью к 15Lys-bis-Nt и ацикловиру

Андронова, В. Л.; Гроховский, С. Л.; Суровая, А.Н.; Gurskii, G. V.; Галегов, Г. А.

doi:10.7868/s0869565215050242

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2015

DOI: 10.7868/s0869565215050242

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Действие димерного аналога нетропсина 15Lys-bis-Nt и ацикловира на репродукцию вируса простого герпеса. Поиск вариантов вируса герпеса с лекарственной устойчивостью к 15Lys-bis-Nt и ацикловиру

В. Л. Андронова¹,

С. Л. Гроховский²,

А.Н. Суровая³

et al.

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2018

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Modern Ethiotropic Chemotherapy of Herpesvirus Infections: Advances, New Trends and Perspectives. Alphaherpesviruses (Part Ii)

Андронова¹

2018

Problems of Virology

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A key role in the treatment of herpesviral infections is played by modified nucleosides and their predecessors - acyclovir, its L-valine ester (valaciclovir) and famciclovir (prodrug of penciclovir). The biological activity of compounds of this class is determined by their similarity to natural nucleosides. After phosphorylation by viral thymidine kinase and then cell enzymes to the triphosphate forms, acyclovir and penciclovir inhibit the activity of viral DNA polymerase and synthesis of viral DNA. The increasing role of herpesvirus infections in human infectious pathology, as well as the development of drug resistance in viruses, mainly in patients with immunodeficiencies of various origins, necessitate the search for new compounds possessing anti-herpesvirus activity, using as a biological target not DNA polymerase, but other viral proteins and enzymes, unique or different from cellular proteins, performing similar functions.

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Modern Ethiotropic Chemotherapy of Herpesvirus Infections: Advances, New Trends and Perspectives. Alphaherpesviruses (Part Ii)

Андронова¹

2018

Problems of Virology

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scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Cited by 1 publication

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Modern Ethiotropic Chemotherapy of Herpesvirus Infections: Advances, New Trends and Perspectives. Alphaherpesviruses (Part Ii)

Modern Ethiotropic Chemotherapy of Herpesvirus Infections: Advances, New Trends and Perspectives. Alphaherpesviruses (Part Ii)

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