Детектирование Клеток, Содержащих Интернализованные Мультидоменные Магнитные Наночастицы Оксида Железа (II, III), Методом Магнитно-Резонансной Томографии

Енукашвили, Н. И.; Kotkas, I. E.; Боголюбов, Д.С.; Котова, А.В.; Боголюбова, И.О.; Багаева, В.В.; Левчук, К.А.; Масленникова, И.И.; Иволгин, Д.А.; Артамонов, А.Ю.; Марченко, Н.В.; Миндукшев, И.В.

doi:10.21883/jtf.2020.09.49671.402-19

Cited by 2 publications

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“…МСК также могут доставлять наночастицы (НЧ), загруженные лекарственными препаратами, к специфическим мишеням. Первоначальные исследования представили роль МСК, нагруженных магнитными и флуоресцентно мечеными НЧ в диагностике [115]. M. Roger et al показали, что кумарин-6-окрашенные полимолочнокислые НЧ (PLA-NPs) и липидные нанокапсулы (LNCs) эффективно поглощаются МСК в зависимом от концентрации и от времени способом, не влияя на жизнеспособность и дифференцировку МСК [116].…”

Section: клекти опухолиunclassified

Mesenchymal multipotent stromal cells and cancer safety: two sides of the same coin or a double-edged sword (review of foreign literature)

Ivolgin

Кудлай

2021

Ross. ž. det. gematol. onkol.

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Knowledge about the mechanisms of action of mesenchymal multipotent stromal cells (MSC) has undergone a significant evolution since their discovery. From the first attempts to use the remarkable properties of MSC in restoring the functions of organs and tissues, the most important question arose – how safe their use would be? One of the aspects of safety of the use of such biomaterial is tumorogenicity and oncogenicity. Numerous studies have shown that the mechanisms by which MSC realize their regenerative potential can, in principle, have a stimulating effect on tumor cells. This review presents specific mechanisms that have a potentially pro-tumor effect, which include the homing of MSC to the tumor site, support for replicative and proliferative signaling of both cancer cells and cancer stem cells, angiogenesis, and effects on the epithelial-mesenchymal transition. Along with pro-tumor mechanisms, the mechanisms of possible antitumor action are also described – direct suppression of tumor growth, loading and transportation of chemotherapeutic agents, oncolytic viruses, genetic modifications for targeting cancer, delivery of “suicide genes” to the tumor. Also, in conclusion, a small review of the current clinical trials of MSC as antitumor agents for malignant neoplasms of various localization (gastrointestinal tract, lungs, ovaries) is given.

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Section: клекти опухолиunclassified

Mesenchymal multipotent stromal cells and cancer safety: two sides of the same coin or a double-edged sword (review of foreign literature)

Ivolgin

Кудлай

2021

Ross. ž. det. gematol. onkol.

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The effectiveness of autologous mesenchymal stem cells in the treatment of liver cirrhosis and the method of their visualization in the patient’s body

Kotkas

Енукашвили

Asadulayev

et al. 2020

Bulletin of the Russian Military Medical Academy

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Abstract. The effectiveness of the influence of autologous mesenchymal stem cells on the function of liver tissue in liver cirrhosis of alimentary etiology is considered, as well as the possibility of visualization of the introduced cell structures with subsequent cytological confirmation. To be able to track autologous mesenchymal stem cells introduced in the patients body, they were labeled with iron oxide nanoparticles. Visualization of the introduced cell structures was performed using magnetic resonance imaging and ultrasound examination of the liver. 6 months after the cell therapy, clinical and biochemical blood tests, lidocaine test results, elastography indicators were evaluated, and the dynamics of hepatic encephalopathy was evaluated. The effectiveness of using autologous mesenchymal stem cells was evidenced by the improvement of the above indicators. Also, 6 months after treatment, a liver tissue biopsy was performed from the sites of fixation of previously introduced cell structures. Histological examination revealed the largest number of labeled cells in the liver micro-nodes, as well as at the borders of micro-nodes and fibrous septa. The use of cell therapy in a patient suffering from liver cirrhosis of alimentary etiology helped to improve the indicators of laboratory and instrumental research methods. No complications were detected during the procedure.

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Детектирование Клеток, Содержащих Интернализованные Мультидоменные Магнитные Наночастицы Оксида Железа (II, III), Методом Магнитно-Резонансной Томографии

Cited by 2 publications

References 0 publications

Mesenchymal multipotent stromal cells and cancer safety: two sides of the same coin or a double-edged sword (review of foreign literature)

Mesenchymal multipotent stromal cells and cancer safety: two sides of the same coin or a double-edged sword (review of foreign literature)

The effectiveness of autologous mesenchymal stem cells in the treatment of liver cirrhosis and the method of their visualization in the patient’s body

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