Дискуссионные Проблемы Генетического Полиморфизма Рецептора Витамина D При Бронхиальной Астме

Abstract

The review presents information on variants of Vitamin D receptor’s genetic polymorphism, ensuring the direct physiolo­gical effects of the Vitamin via stimulation of nuclear cellular me­chanisms. The article was aimed at raising awareness of the glo­bal scientific advances in the field of Vitamin D receptor’s genetic polymorphism and its association with bronchopulmonary patho­logy in various regions of the planet. The search of scientific refe­rences was carried out in the Scopus, Web of Science, The Cochrane Library, Pubmed, ResearchGate, Russian Science Citation Index (RINC) information databases. The regulatory potential of the Vitamin D active hormonal effects in the bronchopulmonary patho­logy, especially in bronchial asthma (BA), remains unclear in terms of its pathogenetic links. Individual alleles inherent in the receptor genetics were studied, primarily in children with BA across the world. The results were compared as to levels of Vitamin D supplementation, BA symptoms and course The divergences were found in the four variants of alleles: Fok1, Apal, BsmI, TaqI. Those divergences prevail in the individual ethnic populations, limiting our capacities of drawing unambiguous conclusions, although the relationship between the course of BA and the deficient Vitamin’s status remains predominant. It is necessary to widen the database prospectively, to clarify the genetic variants of all the components involved in the metabolism and the Vitamin’s effects (transporter proteins, cytochrome P450 and vitamin D receptor) while the research geography is also expanding in the world.